CSF protein biomarkers for proximal axonal damage improve prognostic accuracy in the acute phase of Guillain-Barré syndrome

2009 ◽  
Vol 40 (1) ◽  
pp. 42-49 ◽  
Author(s):  
A. Petzold ◽  
J. Brettschneider ◽  
K. Jin ◽  
G. Keir ◽  
N.M.F. Murray ◽  
...  
Keyword(s):  
Acute Phase ◽  
Axonal Damage ◽  
Guillain Barre Syndrome ◽  
Protein Biomarkers ◽  
Prognostic Accuracy ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Changes in motor nerve excitability in acute phase Guillain‐Barré syndrome

2021 ◽  
Author(s):  
Judith Drenthen ◽  
Badrul Islam ◽  
Zhahirul Islam ◽  
Quazi D. Mohammad ◽  
Ellen M. Maathuis ◽  
...  
Keyword(s):  
Acute Phase ◽  
Motor Nerve ◽  
Guillain Barre Syndrome ◽  
Nerve Excitability ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Episodes of Guillain-Barré syndrome associated with the acute phase of HIV-1 infection and with recurrence of viremia

2006 ◽  
Vol 64 (3a) ◽  
pp. 606-608 ◽  
Author(s):  
Gleusa de Castro ◽  
Patrícia Gomes Bastos ◽  
Roberto Martinez ◽  
José Fernando de Castro Figueiredo
Keyword(s):  
Acute Phase ◽  
Limit Of Detection ◽  
Severe Case ◽  
Guillain Barre Syndrome ◽  
Immunologic Response ◽  
Guillain Barré Syndrome ◽  
Autonomic Instability ◽  
Acute Hiv ◽  
Guillain Barré ◽  
Hiv 1

We report a severe case of Guillain-Barré syndrome (GBS) characterized by flaccid areflexive tetraplegia and signs of autonomic instability related to acute HIV-1 infection, and the occurrence of relapse episodes coinciding with the detection of HIV-1 RNA in blood during the phase of irregular treatment with antiretroviral agents. The patient has been asymptomatic for 3 years and has an HIV-1 load below the limit of detection. The recurrence of GBS in this case may be related to alterations of the immunologic response caused by disequilibrium in the host-HIV relationship due to the increase in HIV-1 viremia.

Axonal damage in Guillain-Barré syndrome

1991 ◽  
Vol 14 (10) ◽  
pp. 997-1002 ◽  
Author(s):  
Frans G. A. Van Der Meché ◽  
Jan Meulstee ◽  
Ruud P. Kleyweg
Keyword(s):  
Axonal Damage ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Isolation of infective Zika virus from urine and saliva of patients in Brazil

2016 ◽  
Author(s):  
Myrna C. Bonaldo ◽  
Ieda P. Ribeiro ◽  
Noemia S. Lima ◽  
Alexandre A. C. dos Santos ◽  
Lidiane S. R. Menezes ◽  
...  
Keyword(s):  
Acute Phase ◽  
Zika Virus ◽  
Sexual Transmission ◽  
Critical Factor ◽  
Transmission Efficiency ◽  
Guillain Barre Syndrome ◽  
Molecular Diagnostic ◽  
Viral Loads ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

ABSTRACTBACKGROUNDZika virus (ZIKV) is an emergent threat provoking a worldwide explosive outbreak. Since January 2015, 41 countries reported autochthonous cases. In Brazil, an increase in Guillain-Barré syndrome and microcephaly cases was linked to ZIKV infections. A recent report describing low experimental transmission efficiency of its main putative vector, Ae. aegypti, in conjunction with apparent sexual transmission notifications prompted the investigation of other potential sources of viral dissemination. Urine and saliva have been previously established as useful tools in ZIKV diagnosis. However, no evidence regarding the infectivity of ZIKV particles present in saliva and urine has been obtained yet.METHODOLOGY/PRINCIPAL FINDINGSNine urine and five saliva samples from nine patients from Rio de Janeiro presenting rash and other typical Zika acute phase symptoms were inoculated in Vero cell culture and submitted to specific ZIKV RNA detection and quantification through, respectively, NAT-Zika, RT-PCR and RT-qPCR. Two ZIKV isolates were achieved, one from urine and one from saliva specimens. ZIKV nucleic acid was identified by all methods in four patients. Whenever both urine and saliva samples were available from the same patient, urine viral loads were higher, corroborating the general sense that it is a better source for ZIKV molecular diagnostic. In spite of this, from the two isolated strains, each from one patient, only one derived from urine, suggesting that other factors, like the acidic nature of this fluid, might interfere with virion infectivity. The complete genome of both ZIKV isolates was obtained. Phylogenetic analysis revealed similarity with strains previously isolated during the South America outbreak.CONCLUSIONS/SIGNIFICANCEThe detection of infectious ZIKV particles in urine and saliva of patients during the acute phase may represent a critical factor in the spread of virus. The epidemiological relevance of this finding, regarding the contribution of alternative non vectorial ZIKV transmission routes, needs further investigation.AUTHOR SUMMARYThe American continent has recently been the scene of a devastating epidemic of Zika virus and its severe manifestations, such as microcephaly in newborns and Guillain-Barré Syndrome. Zika virus, first detected in 1947 in Africa, only from 2007 started provoking outbreaks. Zika, dengue and chikungunya viruses are primarily transmitted by Aedes mosquitoes. Dengue is endemic in Brazil for almost 30 years, and the country is largely infested by its main vector, Aedes aegypti. Chikungunya virus entered the country in late 2014 and Zika presence was confirmed eight months later. Nevertheless, Zika notifications multiplied and spread across the country with unprecedented speed, raising the possibility of other transmission routes. This hypothesis was strengthened by some recent reports of Zika sexual transmission in Ae. aegypti-free areas and by the description of a low transmission efficiency to Zika virus in local Ae. aegypti. We found Zika active particles in both urine and saliva of acute phase patients, and a finding that was promptly announced by Fiocruz via Press Conference on February 5, 2016. In this work, we bring up the potential alternative person-to-person infection routes beyond the vectorial transmission, that might have epidemiological relevance.

The acute phase reactant, fibrinogen, as a guide to plasma exchange therapy for acute Guillain-Barré syndrome

2006 ◽  
Vol 21 (2) ◽  
pp. 105-110 ◽  
Author(s):  
Rashmi Sanjay ◽  
Janice Flanagan ◽  
Donata Sodano ◽  
Kenneth C. Gorson ◽  
Allan H. Ropper ◽  
...  
Keyword(s):  
Plasma Exchange ◽  
Acute Phase ◽  
Acute Phase Reactant ◽  
Guillain Barre Syndrome ◽  
Plasma Exchange Therapy ◽  
Phase Reactant ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

Cytokines in myelin and axonal damage in Guillain-Barré syndrome: An immunohistochemical study

1996 ◽  
Vol 6 (2) ◽  
pp. S26
Author(s):  
G.A. Putzu ◽  
A.M. Bâeta ◽  
D. Figarella-Branger ◽  
N. Bianco ◽  
J.F. Pellissier
Keyword(s):  
Immunohistochemical Study ◽  
Axonal Damage ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré

scholarly journals Pain during the acute phase of Guillain–Barré syndrome

Medicine ◽  
2018 ◽  
Vol 97 (34) ◽  
pp. e11595 ◽  
Author(s):  
Shaoli Yao ◽  
Hongxi Chen ◽  
Qin Zhang ◽  
Ziyan Shi ◽  
Ju Liu ◽  
...  
Keyword(s):  
Acute Phase ◽  
Guillain Barre Syndrome ◽  
Guillain Barré Syndrome ◽  
Guillain Barré
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