Electrical stimulation cramp threshold frequency correlates well with the occurrence of skeletal muscle cramps

2009 ◽  
Vol 39 (3) ◽  
pp. 364-368 ◽  
Author(s):  
Kevin C. Miller ◽  
Kenneth L. Knight
Keyword(s):  
Skeletal Muscle ◽  
Electrical Stimulation ◽  
Muscle Cramps ◽  
Threshold Frequency ◽  
Cramp Threshold

Investigation of Muscle Cramps in Patients With Cirrhosis Using Electrical Stimulation Cramp Threshold Frequency

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S577-S579
Author(s):  
Rishi Bolla ◽  
Cynthia Bodkin ◽  
Marwan Ghabril ◽  
Naga Chalasani ◽  
Raj Vuppalanchi
Keyword(s):  
Electrical Stimulation ◽  
Muscle Cramps ◽  
Threshold Frequency ◽  
Cramp Threshold

scholarly journals Are electrically induced muscle cramps able to increase the cramp threshold frequency, when induced once a week?

2015 ◽  
Vol 7 (3) ◽  
Author(s):  
Michael Behringer ◽  
Tobias Walter Link ◽  
Johannes Caspar Konrad Montag ◽  
Molly Leigh McCourt ◽  
Joachim Mester
Keyword(s):  
Creatine Kinase ◽  
Muscle Damage ◽  
Intervention Group ◽  
Term Effect ◽  
Short Term ◽  
Muscle Cramps ◽  
Threshold Frequency ◽  
Single Bout ◽  
The Individual ◽  
Cramp Threshold

The cramp threshold frequency (CTF) is known to be positively correlated with the individual cramp susceptibility. Here we assessed CTF changes after two bouts of electrically induced muscle cramps (EIMCs). The EIMCs (6×5 sec) were unilaterally induced twice (separated by one week) in the gastrocnemius of an intervention group (n=8), while 5 participants served as control. The CTF increased from 25.1±4.6 Hz at baseline to 31.4±9.0 Hz and 31.7±8.5 Hz 24 h after bout 1 and 2 (P<0.05). Thereafter, the CTF declined following both bouts to reach values of 28.0±6.7 Hz and 29.1±7.7 Hz after 72 h after bout 1 and 2. Creatine kinase (CK) activity and perceived discomfort during cramps was lower after bout 2 (P<0.05). CTF, CK, and discomfort did not change in CG. That is, a single bout of EIMCs induces a 24 h CTF increment and a second bout sustains this effect, while perceived discomfort and muscle damage decreases. This short term effect may help athletes to reduce the cramp susceptibility for an important match.

scholarly journals Initial Electrical Stimulation Frequency and Cramp Threshold Frequency and Force

2012 ◽  
Vol 47 (6) ◽  
pp. 643-647 ◽  
Author(s):  
Kevin C. Miller ◽  
Kenneth L. Knight
Keyword(s):  
Electrical Stimulation ◽  
Outcome Measure ◽  
Tibial Nerve ◽  
Stimulation Frequency ◽  
Maximal Voluntary Isometric Contraction ◽  
Main Outcome Measure ◽  
Initial Frequency ◽  
Threshold Frequency ◽  
Cramp Threshold ◽  
Over Time

Context In the electrically induced cramp model, the tibial nerve is stimulated at an initial frequency of 4 Hz with increases in 2-Hz increments until the flexor hallucis brevis cramps. The frequency at which cramping occurs (ie, threshold frequency [TF]) can vary considerably. A potential limitation is that multiple subthreshold stimulations before TF might induce fatigue, which is operationally defined as a decrease in maximal voluntary isometric contraction (MVIC) force, thereby biasing TF. Objective To determine if TF is similar when initially stimulated at 4 Hz or 14 Hz and if MVIC force is different among stimulation frequencies or over time (precramp, 1 minute postcramp, and 5 minutes postcramp). Design Crossover study. Setting Laboratory. Patients or Other Participants Twenty participants (13 males: age = 20.6 ± 2.9 years, height = 184.4 ± 5.7 cm, mass = 76.3 ± 7.1 kg; 7 females: age = 20.4 ± 3.5 years, height = 166.6 ± 6.0 cm, mass = 62.4 ± 10.0 kg) who were prone to cramps. Intervention(s) Participants performed 20 practice MVICs. After a 5-minute rest, three 2-second MVICs were recorded and averaged for the precramp measurement. Participants were stimulated at either 4 Hz or 14 Hz, and the frequency was increased in 2-Hz increments from each initial frequency until cramp. The MVIC force was reevaluated at 1 minute and 5 minutes postcramp. Main Outcome Measure(s) The TF and MVIC force. Results Initial stimulation frequency did not affect TF (4 Hz = 16.2 ± 3.8 Hz, 14 Hz = 17.1 ± 5.0 Hz; t19=1.2, P = .24). Two participants had inaccurate TFs when initially stimulated at 14 Hz; they cramped at 10 and 12 Hz in the 4-Hz condition. The MVIC force did not differ between initial frequencies (F1,19 = 0.9, P = .36) but did differ over time (F2,38 = 5.1, P = .01). Force was lower at 1 minute postcramp (25.1 ± 10.1 N) than at precramp (28.7 ± 7.8 N; P < .05) but returned to baseline at 5 minutes postcramp (26.7 ± 8.9 N; P > .05). Conclusions The preferred initial stimulation frequency might be 4 Hz because it did not alter or overestimate TF. The MVIC force was lower at 1 minute postcramp, suggesting the induced cramp rather than the varying electrical frequencies affected force. A 1- to 5-minute rest should be provided postcramp induction if multiple cramps are induced.

Significant and serious dehydration does not affect skeletal muscle cramp threshold frequency

2012 ◽  
Vol 47 (11) ◽  
pp. 710-714 ◽  
Author(s):  
Kyle W Braulick ◽  
Kevin C Miller ◽  
Jay M Albrecht ◽  
Jared M Tucker ◽  
James E Deal
Keyword(s):  
Skeletal Muscle ◽  
Muscle Cramp ◽  
Threshold Frequency ◽  
Cramp Threshold

scholarly journals Acute Passive Static Stretching and Cramp Threshold Frequency

2017 ◽  
Vol 52 (10) ◽  
pp. 918-924 ◽  
Author(s):  
Gino Panza ◽  
Justin Stadler ◽  
Donal Murray ◽  
Nicholas Lerma ◽  
Tomas Barrett ◽  
...  
Keyword(s):  
Outcome Measure ◽  
Clinical Problem ◽  
Static Stretching ◽  
Static Stretch ◽  
Muscle Cramps ◽  
Threshold Frequency ◽  
Independent Variable ◽  
Exercise Associated Muscle Cramps ◽  
Cramp Threshold ◽  
Common Clinical Problem

Context:  Exercise-associated muscle cramps are a common clinical problem for athletes. Objective:  To determine whether acute passive static stretching altered cramp threshold frequency (CTF) of electrically induced muscle cramps. Design:  Crossover study. Setting:  Laboratory. Patients or Other Participants:  Seventeen healthy college-aged individuals. Intervention(s):  Stretching or no stretching. Main Outcome Measure(s):  The independent variable was the static stretch versus the no-stretch condition, and the dependent variable was the CTF. Results:  The CTF increased in both the control (pretest: 18.12 ± 6.46 Hz, posttest: 19.65 ± 7.25 Hz; P = .033) and stretching (pretest: 18.94 ± 5.96 Hz, posttest: 20.47 ± 7.12 Hz; P = .049) groups. No difference between the groups was found (t15 = 0.035, P = .97). Conclusions:  Acute passive static stretching did not seem to increase the CTF.

The “KIMWIPE” Effect in Ultra-Thin Cryosections

1985 ◽  
Vol 43 ◽  
pp. 458-459
Author(s):  
I. Taylor ◽  
P. Ingram ◽  
J.R. Sommer
Keyword(s):  
Skeletal Muscle ◽  
Electrical Stimulation ◽  
Muscle Fibers ◽  
Ice Crystals ◽  
Crystal Formation ◽  
Ice Crystal ◽  
Thin Sections ◽  
Skeletal Muscle Fibers ◽  
Freeze Dried ◽  
Ice Crystal Formation

In studying quick-frozen single intact skeletal muscle fibers for structural and microchemical alterations that occur milliseconds, and fractions thereof, after electrical stimulation, we have developed a method to compare, directly, ice crystal formation in freeze-substituted thin sections adjacent to all, and beneath the last, freeze-dried cryosections. We have observed images in the cryosections that to our knowledge have not been published heretofore (Figs.1-4). The main features are that isolated, sometimes large regions of the sections appear hazy and have much less contrast than adjacent regions. Sometimes within the hazy regions there are smaller areas that appear crinkled and have much more contrast. We have also observed that while the hazy areas remain still, the regions of higher contrast visibly contract in the beam, often causing tears in the sections that are clearly not caused by ice crystals (Fig.3, arrows).

scholarly journals Recycled algae-based carbon materials as electroconductive 3D printed skeletal muscle tissue engineering scaffolds

2021 ◽  
Vol 32 (7) ◽  
Author(s):  
Selva Bilge ◽  
Emre Ergene ◽  
Ebru Talak ◽  
Seyda Gokyer ◽  
Yusuf Osman Donar ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Tissue Engineering ◽  
Electrical Stimulation ◽  
Muscle Tissue ◽  
Carbonaceous Material ◽  
Hydrothermal Carbonization ◽  
Skeletal Muscle Tissue ◽  
Myotube Formation ◽  
3D Printed

AbstractSkeletal muscle is an electrically and mechanically active tissue that contains highly oriented, densely packed myofibrils. The tissue has self-regeneration capacity upon injury, which is limited in the cases of volumetric muscle loss. Several regenerative therapies have been developed in order to enhance this capacity, as well as to structurally and mechanically support the defect site during regeneration. Among them, biomimetic approaches that recapitulate the native microenvironment of the tissue in terms of parallel-aligned structure and biophysical signals were shown to be effective. In this study, we have developed 3D printed aligned and electrically active scaffolds in which the electrical conductivity was provided by carbonaceous material (CM) derived from algae-based biomass. The synthesis of this conductive and functional CM consisted of eco-friendly synthesis procedure such as pre-carbonization and multi-walled carbon nanotube (MWCNT) catalysis. CM obtained from biomass via hydrothermal carbonization (CM-03) and its ash form (CM-03K) were doped within poly(ɛ-caprolactone) (PCL) matrix and 3D printed to form scaffolds with aligned fibers for structural biomimicry. Scaffolds were seeded with C2C12 mouse myoblasts and subjected to electrical stimulation during the in vitro culture. Enhanced myotube formation was observed in electroactive groups compared to their non-conductive counterparts and it was observed that myotube formation and myotube maturity were significantly increased for CM-03 group after electrical stimulation. The results have therefore showed that the CM obtained from macroalgae biomass is a promising novel source for the production of the electrically conductive scaffolds for skeletal muscle tissue engineering.

scholarly journals Bioengineered in vitro skeletal muscles as new tools for muscular dystrophies preclinical studies

2021 ◽  
Vol 12 ◽  
pp. 204173142098133
Author(s):  
Juan M. Fernández-Costa ◽  
Xiomara Fernández-Garibay ◽  
Ferran Velasco-Mallorquí ◽  
Javier Ramón-Azcón
Keyword(s):  
Skeletal Muscle ◽  
Tissue Engineering ◽  
Electrical Stimulation ◽  
Skeletal Muscles ◽  
Screening Tools ◽  
Muscular Dystrophies ◽  
Preclinical Studies ◽  
Technological Advances ◽  
Topographical Cues

Muscular dystrophies are a group of highly disabling disorders that share degenerative muscle weakness and wasting as common symptoms. To date, there is not an effective cure for these diseases. In the last years, bioengineered tissues have emerged as powerful tools for preclinical studies. In this review, we summarize the recent technological advances in skeletal muscle tissue engineering. We identify several ground-breaking techniques to fabricate in vitro bioartificial muscles. Accumulating evidence shows that scaffold-based tissue engineering provides topographical cues that enhance the viability and maturation of skeletal muscle. Functional bioartificial muscles have been developed using human myoblasts. These tissues accurately responded to electrical and biological stimulation. Moreover, advanced drug screening tools can be fabricated integrating these tissues in electrical stimulation platforms. However, more work introducing patient-derived cells and integrating these tissues in microdevices is needed to promote the clinical translation of bioengineered skeletal muscle as preclinical tools for muscular dystrophies.

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