Catalase overexpression does not impair extensor digitorum longus muscle function in normal mice

2007 ◽  
Vol 36 (6) ◽  
pp. 833-841 ◽  
Author(s):  
Mingju Liu ◽  
Yongping Yue ◽  
Dejia Li ◽  
Dongsheng Duan
Keyword(s):  
Muscle Function ◽  
Extensor Digitorum Longus ◽  
Extensor Digitorum Longus Muscle ◽  
Extensor Digitorum ◽  
Longus Muscle

scholarly journals Alpha 7 integrin preserves the function of the extensor digitorum longus muscle in dystrophin-null mice

2013 ◽  
Vol 115 (9) ◽  
pp. 1388-1392 ◽  
Author(s):  
Chady H. Hakim ◽  
Dean J. Burkin ◽  
Dongsheng Duan
Keyword(s):  
Muscular Dystrophy ◽  
Knockout Mice ◽  
Muscle Function ◽  
Extensor Digitorum Longus ◽  
Transmission Loss ◽  
Extensor Digitorum Longus Muscle ◽  
Extensor Digitorum ◽  
Force Transmission ◽  
Double Knockout ◽  
Longus Muscle

The dystrophin-associated glycoprotein complex (DGC) and the α7β1-integrin complex are two independent protein complexes that link the extracellular matrix with the cytoskeleton in muscle cells. These associations stabilize the sarcolemma during force transmission. Loss of either one of these complexes leads to muscular dystrophy. Dystrophin is a major component of the DGC. Its absence results in Duchenne muscular dystrophy (DMD). Because α7-integrin overexpression has been shown to ameliorate muscle histopathology in mouse models of DMD, we hypothesize that the α7β1-integrin complex can help preserve muscle function. To test this hypothesis, we evaluated muscle force, elasticity, and the viscous property of the extensor digitorum longus muscle in 19-day-old normal BL6, dystrophin-null mdx4cv, α7-integrin-null, and dystrophin/α7-integrin double knockout mice. While nominal changes were found in single knockout mice, contractility and passive properties were significantly compromised in α7-integrin double knockout mice. Our results suggest that DGC and α7β1-integrin complexes may compensate each other to maintain normal skeletal muscle function. α7β1-Integrin upregulation may hold promise to treat not only histological, but also physiological, defects in DMD.

The effect of adenosine deaminase on insulin sensitivity in the extensor digitorum longus muscle of the rat

1986 ◽  
Vol 14 (2) ◽  
pp. 328-329 ◽  
Author(s):  
FRED J. LOZEMAN ◽  
BRENDAN LEIGHTON ◽  
R. A. JOHN CHALLISS ◽  
SIMON A. OWEN ◽  
ERIC A. NEWSHOLME
Keyword(s):  
Insulin Sensitivity ◽  
Adenosine Deaminase ◽  
Extensor Digitorum Longus ◽  
Extensor Digitorum Longus Muscle ◽  
Extensor Digitorum ◽  
Longus Muscle
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