scholarly journals Dose-dependent apoptotic and necrotic myocyte death induced by the β2-adrenergic receptor agonist, clenbuterol

2005 ◽  
Vol 32 (6) ◽  
pp. 767-774 ◽  
Author(s):  
Jatin G. Burniston ◽  
Neil Chester ◽  
William A. Clark ◽  
Lip-Bun Tan ◽  
David F. Goldspink
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Β2 Adrenergic Receptor ◽  
Dose Dependent ◽  
Adrenergic Receptor Agonist

scholarly journals Long-acting β2-adrenergic receptor agonist in pediatric asthma

2004 ◽  
Vol 53 (2) ◽  
pp. 69-75 ◽  
Author(s):  
Shigemi Yoshihara ◽  
Yumi Yamada ◽  
Toshio Abe ◽  
Osamu Arisaka
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Pediatric Asthma ◽  
Β2 Adrenergic Receptor ◽  
Long Acting ◽  
Adrenergic Receptor Agonist

Discovery of a Rapidly Metabolized, Long-Acting β2 Adrenergic Receptor Agonist with a Short Onset Time Incorporating a Sulfone Group Suitable for Once-Daily Dosing

2013 ◽  
Vol 57 (1) ◽  
pp. 159-170 ◽  
Author(s):  
Panayiotis A. Procopiou ◽  
Victoria J. Barrett ◽  
Keith Biggadike ◽  
Peter R. Butchers ◽  
Andrew Craven ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Onset Time ◽  
Once Daily ◽  
Sulfone Group ◽  
Β2 Adrenergic Receptor ◽  
Long Acting ◽  
Adrenergic Receptor Agonist

scholarly journals The 27-kDa Heat Shock Protein Confers Cytoprotective Effects through a β2-Adrenergic Receptor Agonist-Initiated Complex with β-Arrestin

2009 ◽  
Vol 75 (4) ◽  
pp. 855-865 ◽  
Author(s):  
Lalida Rojanathammanee ◽  
Erin B. Harmon ◽  
Laurel A. Grisanti ◽  
Piyarat Govitrapong ◽  
Manuchair Ebadi ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Β2 Adrenergic Receptor ◽  
Adrenergic Receptor Agonist

scholarly journals Reciprocal modulation of helper Th1 and Th17 cells by the β2-adrenergic receptor agonist drug terbutaline

FEBS Journal ◽  
2017 ◽  
Vol 284 (18) ◽  
pp. 3018-3028 ◽  
Author(s):  
Catalina M. Carvajal Gonczi ◽  
Mahdieh Tabatabaei Shafiei ◽  
Ashley East ◽  
Erika Martire ◽  
Meagane H.I. Maurice-Ventouris ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Th17 Cells ◽  
Receptor Agonist ◽  
Β2 Adrenergic Receptor ◽  
Adrenergic Receptor Agonist

β2-Adrenergic receptor agonist induces IL-18 production without IL-12 production

2004 ◽  
Vol 151 (1-2) ◽  
pp. 137-147 ◽  
Author(s):  
Hideo K Takahashi ◽  
Hiromi Iwagaki ◽  
Shuji Mori ◽  
Tadashi Yoshino ◽  
Noriaki Tanaka ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Β2 Adrenergic Receptor ◽  
Adrenergic Receptor Agonist

Porcine hepatic response to sepsis and its amplification by an adrenergic receptor α1 agonist and a β2 antagonist

1998 ◽  
Vol 95 (4) ◽  
pp. 467-478 ◽  
Author(s):  
D. TIGHE ◽  
R. MOSS ◽  
D. BENNETT
Keyword(s):  
Inflammatory Response ◽  
G Protein ◽  
Protein Complex ◽  
Adrenergic Receptor ◽  
Receptor Agonist ◽  
Cell Surface Receptor ◽  
Ultrastructural Changes ◽  
Β2 Adrenergic Receptor ◽  
Adrenergic Receptor Agonist ◽  
Septic Group

1.We investigated the effect of adrenergic receptor stimulation or inhibition on the hepatic ultrastructural changes in a porcine faecal peritonitis model of multi-organ failure. We infused either the α1 adrenergic receptor agonist methoxamine or the β2 adrenergic receptor antagonist ICI 118551 during 8 ;h of the study. 2.Anaesthetized pigs (25–30 ;kg) were divided into four non-septic groups (control, non-septic, non-septic methoxamine and non-septic ICI 118551) and three septic groups (septic, septic methoxamine and septic ICI 118551). 3.Changes in hepatic ultrastructure were measured by morphometric analysis. The septic group was significantly worse than all the non-septic groups. Septic methoxamine and septic ICI 118551 were significantly worse than the septic group. 4.Septic methoxamine and septic ICI 118551 had a significantly increased perisinusoidal space; septic methoxamine had significant hepatocyte vacuolation. 5.Hepatic ultrastructural changes were independent of hepatic blood flow. 6.Septic methoxamine had significant myocardial depression. 7.The α1 adrenergic receptor agonist methoxamine or the β2 antagonist ICI 118551 both amplified the hepatic injury normally found during sepsis in our porcine model. 8.These findings suggest that during sepsis a protective endogenous β2 adrenergic receptor-mediated anti-inflammatory response is activated via cell membrane transduction to stimulate the trimeric G-protein complex Gs and activate the second cell messenger cAMP. 9.In addition, it is likely that α1 adrenergic receptor agonists amplify the inflammatory response by stimulating the cell-surface receptor-linked trimeric G-protein complex to activate Gq and the second cell messenger phospholipase C.

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