Epidermal nerve fiber density, axonal swellings and QST as predictors of HIV distal sensory neuropathy

2004 ◽  
Vol 29 (3) ◽  
pp. 420-427 ◽  
Author(s):  
David N. Herrmann ◽  
Michael P. McDermott ◽  
Don Henderson ◽  
Lin Chen ◽  
Kwame Akowuah ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Sensory Neuropathy ◽  
Fiber Density ◽  
Epidermal Nerve Fiber Density ◽  
Nerve Fiber Density ◽  
Axonal Swellings ◽  
Epidermal Nerve Fiber

scholarly journals Co-localization of pain and reduced intra-epidermal nerve fiber density in individuals with HIV-associated sensory neuropathy

2019 ◽  
Author(s):  
Imraan G Patel ◽  
Peter R Kamerman
Keyword(s):  
Nerve Fiber ◽  
Sensory Neuropathy ◽  
The Other ◽  
Point Estimate ◽  
Poor Correlation ◽  
Fiber Density ◽  
Biopsy Site ◽  
Epidermal Nerve Fiber Density ◽  
Nerve Fiber Density ◽  
Epidermal Nerve Fiber

AbstractIntroductionThere is poor correlation between decreases in intra-epidermal nerve fiber density (IENFD) and the presence of pain in HIV-associated sensory neuropathy (HIV-SN) and other painful distal symmetrical polyneuropathies.ObjectiveWe investigated whether in individuals with HIV-SN, having pain at the ankle skin biopsy site was associated with lower IENFD compared to when there was no pain at the ankle biopsy site.MethodsWe recruited 15 individuals with symptomatic HIV-SN. Nine had pain at the site where the ankle biopsy was taken, while six did not. Skin punch biopsies for IENFD quantification were taken from the ankle and the thigh. Contrasts between the two groups were made using the overlap of confidence interval (CI) method.ResultsIENFD was substantially lower in the group that had pain at the site of the ankle biopsy compared to the other group [6.6 (CI: 5.3 to 7.2) vs. 3.3 (CI: 10.0 to 15.0) fibers/mm]. However, there was no group differences at the thigh biopsy site [15.6 (CI: 15.0 to 15.9) vs 16.2 (CI: 14.5 to 17.8) fibers/mm]. When taking the ratio of ankle IENFD:thigh IENFD, the point estimate for the pain at the ankle group [0.43 (CI: 0.36 to 0.48)] was about half that of the other group [0.81 (CI: 0.68 to 0.87)].ConclusionThus, co-localization of pain to the ankle is associated with meaningful decreases in ankle IENFD.SummaryHaving pain at the ankle biopsy site is associated with lower intra-epidermal nerve fiber density compared to not having pain at the ankle biopsy site.

scholarly journals Epidermal nerve fiber density, oxidative stress, and mitochondrial haplogroups in HIV-infected Thais initiating therapy

AIDS ◽  
2014 ◽  
Vol 28 (11) ◽  
pp. 1625-1633 ◽  
Author(s):  
Todd Hulgan ◽  
Rebecca T. Levinson ◽  
Mariana Gerschenson ◽  
Nittaya Phanuphak ◽  
Jintanat Ananworanich ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nerve Fiber ◽  
Mitochondrial Haplogroups ◽  
Fiber Density ◽  
Epidermal Nerve Fiber Density ◽  
Nerve Fiber Density ◽  
Epidermal Nerve Fiber

scholarly journals Ethnic differences in epidermal nerve fiber density

2013 ◽  
Vol 48 (3) ◽  
pp. 462-464 ◽  
Author(s):  
Cecilia M. Shikuma ◽  
Justin C. McArthur ◽  
Gigi J. Ebenezer ◽  
Jintanat Ananworanich ◽  
Nipat Teeratakulpisarn ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Ethnic Differences ◽  
Fiber Density ◽  
Epidermal Nerve Fiber Density ◽  
Nerve Fiber Density ◽  
Epidermal Nerve Fiber

scholarly journals Distinctive low epidermal nerve fiber density in schwannomatosis patients provides a major parameter for diagnosis and differential diagnosis

2019 ◽  
Vol 30 (2) ◽  
pp. 386-391 ◽  
Author(s):  
Said C. Farschtschi ◽  
Lan Kluwe ◽  
Gerhard Schön ◽  
Reinhard E. Friedrich ◽  
Jakob Matschke ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Nerve Fiber ◽  
Fiber Density ◽  
Epidermal Nerve Fiber Density ◽  
Major Parameter ◽  
Nerve Fiber Density ◽  
Epidermal Nerve Fiber

scholarly journals Epidermal Nerve Fiber Density

1998 ◽  
Vol 55 (12) ◽  
pp. 1513 ◽  
Author(s):  
Justin C. McArthur ◽  
E. Adelaine Stocks ◽  
Peter Hauer ◽  
David R. Cornblath ◽  
John W. Griffin
Keyword(s):  
Nerve Fiber ◽  
Fiber Density ◽  
Epidermal Nerve Fiber Density ◽  
Nerve Fiber Density ◽  
Epidermal Nerve Fiber
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