Physiology of conduction block in multifocal motor neuropathy and other demyelinating neuropathies

2003 ◽  
Vol 27 (3) ◽  
pp. 285-296 ◽  
Author(s):  
Ryuji Kaji
Keyword(s):  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Motor Neuropathy ◽  
Demyelinating Neuropathies

scholarly journals Motor Nerve Conduction Block Estimation in Demyelinating Neuropathies by Deconvolution

2022 ◽  
Vol 9 (1) ◽  
pp. 23
Author(s):  
Luca Mesin ◽  
Edoardo Lingua ◽  
Dario Cocito
Keyword(s):  
Chronic Inflammatory Demyelinating Polyneuropathy ◽  
Motor Nerve ◽  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Motor Unit Potential ◽  
Motor Neuropathy ◽  
Clinical Methods ◽  
Compound Muscle Action Potentials ◽  
Previous State ◽  
Demyelinating Neuropathies

A deconvolution method is proposed for conduction block (CB) estimation based on two compound muscle action potentials (CMAPs) elicited by stimulating a nerve proximal and distal to the region in which the block is suspected. It estimates the time delay distributions by CMAPs deconvolution, from which CB is computed. The slow afterwave (SAW) is included to describe the motor unit potential, as it gives an important contribution in case of the large temporal dispersion (TD) often found in patients. The method is tested on experimental signals obtained from both healthy subjects and pathological patients, with either Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) or Multifocal Motor Neuropathy (MMN). The new technique outperforms the clinical methods (based on amplitude and area of CMAPs) and a previous state-of-the-art deconvolution approach. It compensates phase cancellations, allowing to discriminate among CB and TD: estimated by the methods of amplitude, area and deconvolution, CB showed a correlation with TD equal to 39.3%, 29.5% and 8.2%, respectively. Moreover, a significant decrease of percentage reconstruction errors of the CMAPs with respect to the previous deconvolution approach is obtained (from a mean/median of 19.1%/16.7% to 11.7%/11.2%). Therefore, the new method is able to discriminate between CB and TD (overcoming the important limitation of clinical approaches) and can approximate patients’ CMAPs better than the previous deconvolution algorithm. Then, it appears to be promising for the diagnosis of demyelinating polyneuropathies, to be further tested in the future in a prospective clinical trial.

P87-T Rapid recovery of motor and sensory conduction block in multifocal motor neuropathy

2019 ◽  
Vol 130 (7) ◽  
pp. e64-e65
Author(s):  
Shuo Yang ◽  
Na Chen ◽  
Lei Zhang ◽  
Ying Wang ◽  
Hengheng Wang ◽  
...  
Keyword(s):  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Rapid Recovery ◽  
Motor Neuropathy ◽  
Sensory Conduction

Focal peripheral neuropathy

2011 ◽  
Author(s):  
Michael Donaghy
Keyword(s):  
Peripheral Nerve ◽  
Immunosuppressive Treatment ◽  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Nerve Damage ◽  
High Dose ◽  
Motor Neuropathy ◽  
Peripheral Nerve Damage ◽  
Entrapment Neuropathies ◽  
Focal Neuropathy

Some causes of focal peripheral nerve damage are self-evident, such as involvement at sites of trauma, tissue necrosis, infiltration by tumour, or damage by radiotherapy. Focal compressive and entrapment neuropathies are particularly valuable to identify in civilian practice, since recovery may follow relief of the compression. Leprosy is a common global cause of focal neuropathy, which involves prominent loss of pain sensation with secondary acromutilation, and requires early antibiotic treatment. Mononeuritis multiplex due to vasculitis requires prompt diagnosis and immunosuppressive treatment to limit the severity and extent of peripheral nerve damage. Various other medical conditions, both inherited and acquired, can present with focal neuropathy rather than polyneuropathy, the most common of which are diabetes mellitus and hereditary liability to pressure palsies. A purely motor focal presentation should raise the question of multifocal motor neuropathy with conduction block, which usually responds well to high-dose intravenous immunoglobulin infusions.

scholarly journals Conduction Block and Nerve Cross-Sectional Area in Multifocal Motor Neuropathy

2019 ◽  
Vol 10 ◽  
Author(s):  
Yi Li ◽  
Jingwen Niu ◽  
Tanxin Liu ◽  
Qingyun Ding ◽  
Shuang Wu ◽  
...  
Keyword(s):  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Cross Sectional Area ◽  
Motor Neuropathy ◽  
Sectional Area ◽  
Cross Sectional

P118 F-wave study in patients with multifocal motor neuropathy with conduction block

1996 ◽  
Vol 99 (4) ◽  
pp. 305
Author(s):  
N. Le Forestier ◽  
B. Chassande ◽  
T. Maisonobe ◽  
N. Birouk ◽  
J.M. Léger ◽  
...  
Keyword(s):  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Motor Neuropathy ◽  
F Wave

Multifocal motor neuropathy with conduction block after campylobacter jejuni enteritis

Neurology ◽  
1997 ◽  
Vol 48 (2) ◽  
pp. 544-544 ◽  
Author(s):  
M. Abbruzzese ◽  
L. Reni ◽  
A. Schenone ◽  
G. L. Mancardi ◽  
A. Primavera
Keyword(s):  
Campylobacter Jejuni ◽  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Motor Neuropathy

Multifocal motor neuropathy with conduction block: Is it a distinct clinical entity?

Neurology ◽  
1992 ◽  
Vol 42 (3) ◽  
pp. 497-497 ◽  
Author(s):  
D. J. Lange ◽  
W. Trojaborg ◽  
N. Latov ◽  
A. P. Hays ◽  
D. S. Younger ◽  
...  
Keyword(s):  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Clinical Entity ◽  
Motor Neuropathy ◽  
Distinct Clinical Entity

Axonal multifocal motor neuropathy without conduction block or other features of demyelination

Neurology ◽  
2002 ◽  
Vol 58 (4) ◽  
pp. 615-620 ◽  
Author(s):  
J.S. Katz ◽  
R.J. Barohn ◽  
S. Kojan ◽  
G.I. Wolfe ◽  
S.P. Nations ◽  
...  
Keyword(s):  
Conduction Block ◽  
Multifocal Motor Neuropathy ◽  
Motor Neuropathy
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