Characterization of B 1 + field variation in brain at 3 T using 385 healthy individuals across the lifespan

2021 ◽  
Author(s):  
Thomas MacLennan ◽  
Peter Seres ◽  
Julia Rickard ◽  
Emily Stolz ◽  
Christian Beaulieu ◽  
...  
Keyword(s):  
Field Variation ◽  
Healthy Individuals

scholarly journals De-Coding the Contributions of the Viral RNAs to Alphaviral Pathogenesis

Pathogens ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 771
Author(s):  
Autumn T. LaPointe ◽  
Kevin J. Sokoloski
Keyword(s):  
Host Response ◽  
Severe Disease ◽  
Review Article ◽  
Structural Proteins ◽  
Virulence Determinants ◽  
Healthy Individuals ◽  
Viral Rnas ◽  
Positive Sense ◽  
Identification And Characterization

Alphaviruses are positive-sense RNA arboviruses that are capable of causing severe disease in otherwise healthy individuals. There are many aspects of viral infection that determine pathogenesis and major efforts regarding the identification and characterization of virulence determinants have largely focused on the roles of the nonstructural and structural proteins. Nonetheless, the viral RNAs of the alphaviruses themselves play important roles in regard to virulence and pathogenesis. In particular, many sequences and secondary structures within the viral RNAs play an important part in the development of disease and may be considered important determinants of virulence. In this review article, we summarize the known RNA-based virulence traits and host:RNA interactions that influence alphaviral pathogenesis for each of the viral RNA species produced during infection. Overall, the viral RNAs produced during infection are important contributors to alphaviral pathogenesis and more research is needed to fully understand how each RNA species impacts the host response to infection as well as the development of disease.

Anti-cholesterol antibodies (ACHA) in patients with different atherosclerotic vascular diseases and healthy individuals. Characterization of human ACHA

2001 ◽  
Vol 156 (1) ◽  
pp. 185-192 ◽  
Author(s):  
Anna Horváth ◽  
George Füst ◽  
István Horváth ◽  
Gábor Vallus ◽  
Jenö Duba ◽  
...  
Keyword(s):  
Vascular Diseases ◽  
Healthy Individuals

scholarly journals Occurrence and characterization of class 1 integrons in Escherichia coli from healthy individuals and those with urinary infection

2017 ◽  
Vol 66 (5) ◽  
pp. 577-583 ◽  
Author(s):  
Clarisse Oliveira-Pinto ◽  
Cristiane Diamantino ◽  
Patrícia L Oliveira ◽  
Mariana P Reis ◽  
Patrícia S Costa ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Infection ◽  
Healthy Individuals ◽  
Class 1 Integrons ◽  
Class 1

scholarly journals Comparative characterization of PCDH19 missense and truncating variants in PCDH19-related epilepsy

2020 ◽  
Author(s):  
Mami Shibata ◽  
Atsushi Ishii ◽  
Ayako Goto ◽  
Shinichi Hirose
Keyword(s):  
Distribution Function ◽  
Intellectual Disability ◽  
Cumulative Distribution Function ◽  
Clinical Phenotype ◽  
Cytoplasmic Domain ◽  
Cumulative Distribution ◽  
Clinical Implications ◽  
Healthy Individuals ◽  
Conserved Domains

AbstractMissense and truncating variants in protocadherin 19 (PCDH19) cause PCDH19-related epilepsy. In this study, we aimed to investigate variations in distributional characteristics and the clinical implications of variant type in PCDH19-related epilepsy. We comprehensively collected PCDH19 missense and truncating variants from the literature and by sequencing six exons and intron–exon boundaries of PCDH19 in our cohort. We investigated the distribution of each type of variant using the cumulative distribution function and tested for associations between variant types and phenotypes. The distribution of missense variants in patients was clearly different from that of healthy individuals and was uniform throughout the extracellular cadherin (EC) domain, which consisted of six highly conserved domains. Truncating variants showed two types of distributions: (1) located from EC domain 1 to EC domain 4, and (2) located from EC domain 5 to the cytoplasmic domain. Furthermore, we also found that later onset seizures and milder intellectual disability occurred in patients with truncating variants located from EC domain 5 to the cytoplasmic domain compared with those of patients with other variants. Our findings provide the first evidence of two types of truncating variants in the PCDH19 gene with regard to distribution and the resulting clinical phenotype.

scholarly journals Characterization of the phenotype of human eosinophils and their progenitors in the bone marrow of healthy individuals

Haematologica ◽  
2019 ◽  
Vol 105 (2) ◽  
pp. e52-e56 ◽  
Author(s):  
Marwan Hassani ◽  
Selma van Staveren ◽  
Erinke van Grinsven ◽  
Marije Bartels ◽  
Kiki Tesselaar ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Healthy Individuals

Characterization of Mesothelin-Specific T Cell Responses in Healthy Individuals

2005 ◽  
Vol 28 (6) ◽  
pp. 631
Author(s):  
Dirk G Brockstedt ◽  
Johannes Hampl ◽  
Keith Bahjat ◽  
Eric Lutz ◽  
Meredith Leong ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Healthy Individuals ◽  
Cell Responses

scholarly journals Characterization of the peripheral blood transcriptome in a repeated measures design using a panel of healthy individuals

Genomics ◽  
2014 ◽  
Vol 103 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Patrick De Boever ◽  
Britt Wens ◽  
Anyiawung Chiara Forcheh ◽  
Hans Reynders ◽  
Vera Nelen ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Repeated Measures ◽  
Healthy Individuals ◽  
Repeated Measures Design ◽  
Blood Transcriptome
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