Assessment of the effects of mimicking tissue microstructural properties on apparent diffusion coefficient and apparent exchange rate in diffusion MRI via a series of specially designed phantoms

2021 ◽  
Author(s):  
Xiaodong Li ◽  
Yafei Bai ◽  
Yupeng Liao ◽  
Sherman Xuegang Xin
Keyword(s):  
Diffusion Coefficient ◽  
Exchange Rate ◽  
Apparent Diffusion Coefficient ◽  
Diffusion Mri ◽  
Microstructural Properties ◽  
Apparent Diffusion

Diffusion MRI shows increased water apparent diffusion coefficient in the brains of cirrhotics

Neurology ◽  
2004 ◽  
Vol 62 (5) ◽  
pp. 762-766 ◽  
Author(s):  
R. Lodi ◽  
C. Tonon ◽  
A. Stracciari ◽  
M. Weiger ◽  
V. Camaggi ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Diffusion Mri ◽  
Apparent Diffusion

Apparent diffusion coefficient measured by diffusion MRI of moving and deforming domains

2020 ◽  
Vol 318 ◽  
pp. 106809
Author(s):  
Imen Mekkaoui ◽  
Jérôme Pousin ◽  
Jan Hesthaven ◽  
Jing-Rebecca Li
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Diffusion Mri ◽  
Apparent Diffusion

NIMG-45. DIFFUSION MRI AS AN EARLY BIOMARKER OF OVERALL SURVIVAL BENEFIT IN RECURRENT GLIOBLASTOMA TREATED WITH IMMUNE CHECKPOINT INHIBITORS

2021 ◽  
Vol 23 (Supplement_6) ◽  
pp. vi139-vi139
Author(s):  
Akifumi Hagiwara ◽  
Yao Jingwen ◽  
Talia Oughourlian ◽  
Chencai Wang ◽  
Catalina Raymond ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Diffusion Mri ◽  
Immune Checkpoint Inhibitors ◽  
Tumor Volume ◽  
Checkpoint Inhibitors ◽  
Post Treatment ◽  
Apparent Diffusion ◽  
Recurrent Gbm

Abstract Diffusion magnetic resonance imaging (MRI) estimates of the apparent diffusion coefficient (ADC) has been revealed to be useful for predicting treatment response in patients with glioblastoma (GBM), with an increase in ADC indicating tumor cell death. The aim of the current study was to investigate whether quantitative changes in diffusion MRI after treatment with immune checkpoint inhibitors (ICI) could predict OS in patients with recurrent GBM. A total of 61 patients were included in this retrospective study with the following inclusion criteria: (i) diagnosis of recurrent GBM treated either with pembrolizumab or nivolumab and (ii) availability of diffusion data in pre- and post-ICI MRI. Tumor volume and median relative apparent diffusion coefficient (rADC) within enhancing tumor with respect to normal-appearing white matter were calculated. Median OS for all patients was 7.6 months (range, 1.0–30.6 months). Results showed that higher post-treatment rADC was associated with significantly longer OS (median, 372 days for rADC ≧ 1.42 versus 211 days for rADC < 1.42; P = 0.01, log-rank test), whereas tumor volume and pre-treatment rADC were not significantly associated with OS. Cox regression analysis revealed post-treatment rADC significantly influences OS (P = 0.02, univariate analysis), even after controlling for age, sex, and IDH status (P = 0.007, multivariate analysis), and additionally controlling for whether surgery was performed after ICI treatment (P = 0.049, multivariate analysis). In conclusion, a high post-treatment rADC may be an early imaging biomarker for identifying OS benefit in recurrent GBM patients receiving ICI treatment.

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