scholarly journals Three‐dimensional gradient and spin‐echo readout for time‐encoded pseudo‐continuous arterial spin labeling: Influence of segmentation factor and flow compensation

2021 ◽  
Author(s):  
Andre M. Paschoal ◽  
Renata F. Leoni ◽  
Bruno F. Pastorello ◽  
Matthias J. P. Osch
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Echo ◽  
Three Dimensional ◽  
Spin Labeling ◽  
Flow Compensation ◽  
Continuous Arterial Spin Labeling

scholarly journals Cerebaral Hyperperfusion in  General Paralysis Patients

2020 ◽  
Author(s):  
Yali Wu ◽  
jingjing li ◽  
wenqing wu
Keyword(s):  
Blood Flow ◽  
Healthy Subjects ◽  
Arterial Spin Labeling ◽  
Parietal Lobe ◽  
Three Dimensional ◽  
Occipital Lobe ◽  
Spin Labeling ◽  
General Paralysis ◽  
Limbic Lobe ◽  
Continuous Arterial Spin Labeling

Abstract Objective This study aimed to identify the cerebral blood flow (CBF) in patients with general paralysis (GP). Methods Three-dimensional pseudo-continuous arterial spin labeling (3D-pCASL) imaging was performed to measure the CBF in twenty patients with GP and twenty healthy subjects(NC). CBF was normalized to reduce variations among subjects. CBF was compared between the groups. Results Compared with the healthy subjects, the patients with GP exhibited increased CBF in the frontal lobe, temporal lobe, insular lobe, limbic lobe, and parietal lobe(all P<0.05). There was no difference in CBF of the occipital lobe between the GP group and the NC group(all P>0.05). Conclusions Our results suggest that the patients with GP may exhibit regional increased CBF, which may be one of the pathogenesis of general paralysis.

scholarly journals Collateral perfusion using arterial spin labeling in symptomatic versus asymptomatic middle cerebral artery stenosis

2017 ◽  
Vol 39 (1) ◽  
pp. 108-117 ◽  
Author(s):  
Xin Lou ◽  
Xiaoxiao Ma ◽  
David S Liebeskind ◽  
Ning Ma ◽  
Chenglin Tian ◽  
...  
Keyword(s):  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Arterial Spin Labeling ◽  
Three Dimensional ◽  
Spin Labeling ◽  
Asymptomatic Group ◽  
Asymptomatic Patients ◽  
The Difference ◽  
Continuous Arterial Spin Labeling ◽  
Antegrade Flow

The purpose was to assess the difference of collaterals in symptomatic versus asymptomatic patients with unilateral middle cerebral artery (MCA) stenosis by comparing cerebral blood flow (CBF) at two post labeling delays (PLD) using three-dimensional pseudo-continuous arterial spin labeling (3D pCASL). Eighty-one patients (49 symptomatic and 32 asymptomatic) with unilateral MCA stenosis ≥50% who underwent pCASL with two PLDs were included. Mean CBF and CBF subtraction images between two PLDs of MCA territories were compared in symptomatic and asymptomatic groups, respectively. Compared with the asymptomatic group, patients with symptomatic MCA stenosis had significantly lower CBF in the MCA territory of stenotic side at each PLD. The CBF of stenotic territory showed greater increase than that of normal side from PLD 1.5 to 2.5 s. The CBF of asymptomatic MCA territory increased similarly with that of symptomatic MCA territory from PLD of 1.5 to 2.5 s in stenotic side, while symptomatic patients experienced significantly slower antegrade flow. On CBF subtraction images, asymptomatic patients showed larger volume of differences between PLD of 1.5 and 2.5 s compared with those of symptomatic patients ( p = 0.037). The results suggest that more robust collateral perfusion on two-delay 3D pCASL is present in asymptomatic patients compared with symptomatic patients.

scholarly journals Multivariate and Univariate Analysis of Continuous Arterial Spin Labeling Perfusion MRI in Alzheimer's Disease

2007 ◽  
Vol 28 (4) ◽  
pp. 725-736 ◽  
Author(s):  
Iris Asllani ◽  
Christian Habeck ◽  
Nikolaos Scarmeas ◽  
Ajna Borogovac ◽  
Truman R Brown ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Multivariate Analysis ◽  
Arterial Spin Labeling ◽  
Spin Echo ◽  
Univariate Analysis ◽  
Region Of Interest ◽  
Spin Labeling ◽  
Planar Imaging ◽  
Continuous Arterial Spin Labeling

Continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI) was combined with multivariate analysis for detection of an Alzheimer's disease (AD)-related cerebral blood flow (CBF) covariance pattern. Whole-brain resting CBF maps were obtained using spin echo, echo planar imaging (SE-EPI) CASL in patients with mild AD ( n=12, age=70.7±8.7 years, 7 males, modified Mini-Mental State Examination (mMMS)=38.7/57±11.1) and age-matched healthy controls (HC) ( n=20; age=72.1±6.5 years, 8 males). A covariance pattern for which the mean expression was significantly higher ( P<0.0005) in AD than in HC was identified containing posterior cingulate, superior temporal, parahippocampal, and fusiform gyri, as well as thalamus, insula, and hippocampus. The results from this analysis were supplemented with those from the more standard, region of interest (ROI) and voxelwise, univariate techniques. All ROIs (17/hemisphere) showed significant decrease in CBF in AD ( P<0.001 for all ROIs, αcorrected=0.05). The area under the ROC curve for discriminating AD versus HC was 0.97 and 0.94 for covariance pattern and gray matter ROI, respectively. Fewer areas of depressed CBF in AD were detected using voxelwise analysis (corrected, P<0.05). These areas were superior temporal, cingulate, middle temporal, fusiform gyri, as well as inferior parietal lobule and precuneus. When tested on extensive split-half analysis to map out the replicability of both multivariate and univariate approaches, the expression of the pattern from multivariate analysis was superior to that of the univariate.

scholarly journals Test–retest reliability of perfusion of the precentral cortex and precentral subcortical white matter on three-dimensional pseudo-continuous arterial spin labeling

2018 ◽  
Vol 46 (9) ◽  
pp. 3788-3795
Author(s):  
Mengqi Liu ◽  
Zhiye Chen ◽  
Lin Ma
Keyword(s):  
White Matter ◽  
Resting State ◽  
Arterial Spin Labeling ◽  
Three Dimensional ◽  
Spin Labeling ◽  
Subcortical White Matter ◽  
Finger Tapping ◽  
Retest Reliability ◽  
Continuous Arterial Spin Labeling ◽  
Test Retest Reliability

Objective This study was performed to evaluate the test–retest reliability of perfusion of the cortex and subcortical white matter on three-dimensional spiral fast spin echo pseudo-continuous arterial spin labeling (3D-ASL). Methods Eight healthy subjects underwent 3D-ASL and structural imaging at the same time each day for 1 week. ASL data acquisition was performed in the resting state and right finger-tapping state. Cerebral blood flow (CBF) images were calculated, and the CBF values of the precentral cortex (PCC) and precentral subcortical white matter (PCSWM) were automatically extracted based on the structural images and CBF images. Results In the resting state, the intraclass correlation coefficient (ICC) of the bilateral PCC was 0.84 (left) and 0.81 (right) and that of the bilateral SCWM was 0.89 (left) and 0.85 (right). In the finger-tapping state, the ICC of the bilateral PCC was 0.91 (left) and 0.87 (right) and that of the bilateral PCSWM was 0.87 (left) and 0.92 (right). The CBF value of the left PCC and PCSWM was not significantly different between the resting state and finger-tapping state on two ASL scans. Conclusion 3D-ASL provides reliable CBF measurement in the cortex and subcortical white matter in the resting or controlled state.

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