Spatial dependency and the role of local susceptibility for velocity selective arterial spin labeling (VS‐ASL) relative tagging efficiency using accelerated 3D radial sampling with a BIR‐8 preparation

2021 ◽  
Author(s):  
James H. Holmes ◽  
Mu‐Lan Jen ◽  
Laura B. Eisenmenger ◽  
Tilman Schubert ◽  
Patrick A. Turski ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Spatial Dependency ◽  
Local Susceptibility ◽  
Radial Sampling

scholarly journals Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling

2020 ◽  
pp. 0271678X2090690
Author(s):  
Samaira Younis ◽  
Casper E Christensen ◽  
Mark B Vestergaard ◽  
Ulrich Lindberg ◽  
Daniel Tolnai ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Brain Structures ◽  
Spin Labeling ◽  
Resonance Spectroscopy ◽  
Double Blind ◽  
Calcitonin Gene ◽  
Total Creatine ◽  
Continuous Arterial Spin Labeling ◽  
Mri Study

Migraine is a complex disorder, involving peripheral and central brain structures, where mechanisms and site of attack initiation are an unresolved puzzle. While abnormal pontine neuronal activation during migraine attacks has been reported, exact implication of this finding is unknown. Evidence suggests an important role of glutamate in migraine, implying a possible association of pontine hyperactivity to increased glutamate levels. Migraine without aura patients were scanned during attacks after calcitonin gene-related peptide and sildenafil in a double-blind, randomized, double-dummy, cross-over design, on two separate study days, by proton magnetic resonance spectroscopy and pseudo-continuous arterial spin labeling at 3T. Headache characteristics were recorded until 24 h after drug administrations. Twenty-six patients were scanned during migraine, yielding a total of 41 attacks. Cerebral blood flow increased in dorsolateral pons, ipsilateral to pain side during attacks, compared to outside attacks (13.6%, p = 0.009). Glutamate levels in the same area remained unchanged during attacks (p = 0.873), while total creatine levels increased (3.5%, p = 0.041). In conclusion, dorsolateral pontine activation during migraine was not associated with higher glutamate levels. However, the concurrently increased total creatine levels may suggest an altered energy metabolism, which should be investigated in future studies to elucidate the role of pons in acute migraine.

scholarly journals Arterial spin labeling demonstrates preserved regional cerebral blood flow in the P301L mouse model of tauopathy

2021 ◽  
pp. 0271678X2110622
Author(s):  
Diana Kindler ◽  
Cinzia Maschio ◽  
Ruiqing Ni ◽  
Valerio Zerbi ◽  
Daniel Razansky ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Arterial Spin Labeling ◽  
Vascular Dysfunction ◽  
Spin Labeling ◽  
Regional Cerebral Blood ◽  
Weighted Magnetic Resonance Imaging ◽  
Disease Stages ◽  
Relationship Of

There is growing evidence for the vascular contribution to cognitive impairment and dementia in Alzheimer’s disease (AD) and other neurodegenerative diseases. While perfusion deficits have been observed in patients with Alzheimer’s disease and tauopaties, little is known about the role of tau in vascular dysfunction. In the present study, regional cerebral blood (rCBF) was characterized in P301L mice with arterial spin labeling. No differences in rCBF in P301L mice compared to their age-matched non-transgenic littermates at mid (10–12 months of age) and advanced (19–21 months of age) disease stages. This was concomitant with preservation of cortical brain structure as assessed with structural T2-weighted magnetic resonance imaging. These results show that hypoperfusion and neurodegeneration are not a phenotype of P301L mice. More studies are thus needed to understand the relationship of tau, neurodegeneration and vascular dysfunction and its modulators in AD and primary tauopathies.

scholarly journals Feasibility of arterial spin labeling in evaluating high- and low-flow peripheral vascular malformations: a case series

2021 ◽  
pp. 20210083
Author(s):  
Sanjeev Ramachandran ◽  
Jonathan Delf ◽  
Christopher Kasap ◽  
William Adair ◽  
Harjeet Rayt ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Vascular Malformations ◽  
Case Series ◽  
Spin Labeling ◽  
Preliminary Evidence ◽  
Low Flow ◽  
Peripheral Vascular ◽  
Perfusion Technique ◽  
Potential Benefits

We present a case series highlighting a novel use of arterial spin labeling (ASL), a MRI perfusion technique, to evaluate both high- and low-flow peripheral vascular malformations (PVMs) across a range of anatomical locations. While the role of ASL in assessing intracranial vascular malformations is more established, there is limited evidence for PVMs. Our results provide preliminary evidence for the feasibility of ASL in imaging PVMs and its potential ability to distinguish between high- and low-flow PVMs. In addition, we demonstrate its ability to identify focal high blood flow, which may indicate the nidus in arteriovenous malformations. Together, these findings have important implications for patient management. We also outline the potential benefits and limitations of ASL in the imaging of PVMs, and provide justification for further validation of its diagnostic performance.

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