One‐minute whole‐brain magnetization transfer ratio imaging with intrinsic B 1 ‐correction

2020 ◽  
Author(s):  
Roya Afshari ◽  
Francesco Santini ◽  
Rahel Heule ◽  
Craig H. Meyer ◽  
Josef Pfeuffer ◽  
...  
Keyword(s):  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Whole Brain ◽  
Transfer Ratio ◽  
Ratio Imaging

Brain atrophy and magnetization transfer ratio following methylprednisolone in multiple sclerosis: short-term changes and long-term implications

2005 ◽  
Vol 11 (2) ◽  
pp. 140-145 ◽  
Author(s):  
Robert J Fox ◽  
Elizabeth Fisher ◽  
Jean Tkach ◽  
Jar-Chi Lee ◽  
Jeffrey A Cohen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Activity ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Short Term ◽  
Whole Brain ◽  
Transfer Ratio ◽  
Short Term Change ◽  
Term Change ◽  
The Impact

Background: The short-term effect of corticosteroids on MRI measures of multiple sclerosis (MS) is not well understood and may have a significant impact when using these quantitative measures to evaluate disease activity and changes following other therapeutic interventions. Objective: To determine the impact of a course of intravenous methylprednisolone (IVMP) on quantitative measures of disease activity and tissue injury in MS patients. Methods: We prospectively measured brain parenchymal fraction (BPF), magnetization transfer ratio (MTR, lesional and whole brain), and lesion volumes on nine weekly brain MRI studies in ten MS patients receiving a course of IVMP. A group of nine MS patients not receiving IVMP served as controls. Results: In comparison to untreated controls, BPF declined over the eight weeks following IVMP treatment (P<0.02). BPF decline was most prominent in patients with secondary progressive MS (SPMS, P<0.03), and was not seen in relapsing-remitting (RR) MS patients. Short-term change in BPF correlated with baseline BPF (r=0.62, P=0.05) and short-term change in lesional MTR (r=-0.55, P=0.03), but not with change in enhancing lesion volume. Short-term change in lesional MTR inversely correlated with baseline lesional and whole brain MTR (r=-0.79, P=0.04 for both). There was no significant difference between treated and control patients in measures of MTR or T2, T1 or enhancing lesion volumes. Conclusions: Patients with SPMS showed a greater decline in BPF following IVMP than RRMS patients. A correlation between changes in BPF and MTR suggest that these changes are secondary to altered water content within MS lesions. Differential response to a standardized therapeutic intervention in RRMS and SPMS suggests that responses to therapy may differ due to a fundamental pathologic difference between early and late stage MS.

Effects of BG-12 on Magnetization Transfer Ratio in Whole Brain and Normal-Appearing Brain Tissue: Findings from the DEFINE Study (S11.004)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. S11.004-S11.004 ◽  
Author(s):  
D. Arnold ◽  
R. Gold ◽  
L. Kappos ◽  
A. Bar-Or ◽  
G. Giovannoni ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Whole Brain ◽  
Transfer Ratio

scholarly journals Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study

2014 ◽  
Vol 40 (4) ◽  
pp. spcone-spcone
Author(s):  
Hendrikus J.A. Crooijmans ◽  
Thomas D. Ruder ◽  
Wolf-Dieter Zech ◽  
Sandra Somaini ◽  
Klaus Scheffler ◽  
...  
Keyword(s):  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Postmortem Study ◽  
Ratio Imaging

Cardiovascular magnetization transfer ratio imaging compared with histology: A postmortem study

2013 ◽  
Vol 40 (4) ◽  
pp. 915-919 ◽  
Author(s):  
Hendrikus J.A. Crooijmans ◽  
Thomas D. Ruder ◽  
Wolf-Dieter Zech ◽  
Sandra Somaini ◽  
Klaus Scheffler ◽  
...  
Keyword(s):  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Postmortem Study ◽  
Ratio Imaging

scholarly journals Prevalence of Grey Matter Pathology in Early Multiple Sclerosis Assessed by Magnetization Transfer Ratio Imaging

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24969 ◽  
Author(s):  
Lydie Crespy ◽  
Wafaa Zaaraoui ◽  
Mathias Lemaire ◽  
Audrey Rico ◽  
Anthony Faivre ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Grey Matter ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Ratio Imaging

scholarly journals Delineation of cortical pathology in multiple sclerosis using multi-surface magnetization transfer ratio imaging

2016 ◽  
Vol 12 ◽  
pp. 858-868 ◽  
Author(s):  
David A. Rudko ◽  
Mishkin Derakhshan ◽  
Josefina Maranzano ◽  
Kunio Nakamura ◽  
Douglas L. Arnold ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Surface Magnetization ◽  
Ratio Imaging ◽  
Cortical Pathology
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