scholarly journals Combining chemical exchange saturation transfer and 1 H magnetic resonance spectroscopy for simultaneous determination of metabolite concentrations and effects of magnetization exchange

2020 ◽  
Vol 85 (4) ◽  
pp. 1766-1782
Author(s):  
Maike Hoefemann ◽  
André Döring ◽  
Nicole Damara Fichtner ◽  
Roland Kreis
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Simultaneous Determination ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Resonance Spectroscopy ◽  
Saturation Transfer ◽  
Metabolite Concentrations

Simultaneous Determination of Ibuprofen and Acetaminophen in Pharmaceutical Preparations by Proton Magnetic Resonance Spectroscopy

1994 ◽  
Vol 77 (6) ◽  
pp. 1443-1446
Author(s):  
Sajid Husain ◽  
M Kifayatullah ◽  
R Sekhar
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Simultaneous Determination ◽  
Internal Standard ◽  
Pharmaceutical Preparations ◽  
Aromatic Proton ◽  
Butyl Alcohol ◽  
Resonance Spectroscopy ◽  
Specific Method

Abstract A simple, rapid, and specific method for simultaneous determination of ibuprofen and acetaminophen in pharmaceutical preparations by 1H Fourier transform nuclear magnetic resonance spectroscopy was developed using methyl and aromatic proton signal areas against ferf-butyl alcohol as internal standard. Average recoveries of ibuprofen and acetaminophen were 99.2 and 98.6%, with standard deviations of ± 0.76 and ± 0.81, respectively. The results were compared with those obtained using the procedure recommended by the British Pharmacopoeia and were in close agreement.

scholarly journals pH Mapping of Skeletal Muscle by Chemical Exchange Saturation Transfer (CEST) Imaging

Cells ◽  
2020 ◽  
Vol 9 (12) ◽  
pp. 2610
Author(s):  
Yu-Wen Chen ◽  
Hong-Qing Liu ◽  
Qi-Xuan Wu ◽  
Yu-Han Huang ◽  
Yu-Ying Tung ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Electrical Stimulation ◽  
Magnetic Resonance ◽  
Ph Value ◽  
Chemical Exchange ◽  
Chemical Exchange Saturation Transfer ◽  
Resonance Spectroscopy ◽  
Saturation Transfer ◽  
Ph Changes ◽  
Cest Imaging

Magnetic resonance imaging (MRI) is extensively used in clinical and basic biomedical research. However, MRI detection of pH changes still poses a technical challenge. Chemical exchange saturation transfer (CEST) imaging is a possible solution to this problem. Using saturation transfer, alterations in the exchange rates between the solute and water protons because of small pH changes can be detected with greater sensitivity. In this study, we examined a fatigued skeletal muscle model in electrically stimulated mice. The measured CEST signal ratio was between 1.96 ppm and 2.6 ppm in the z-spectrum, and this was associated with pH values based on the ratio between the creatine (Cr) and the phosphocreatine (PCr). The CEST results demonstrated a significant contrast change at the electrical stimulation site. Moreover, the pH value was observed to decrease from 7.23 to 7.15 within 20 h after electrical stimulation. This pH decrease was verified by 31P magnetic resonance spectroscopy and behavioral tests, which showed a consistent variation over time.

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