Accelerating T 2 mapping of the brain by integrating deep learning priors with low‐rank and sparse modeling

2020 ◽  
Vol 85 (3) ◽  
pp. 1455-1467
Author(s):  
Ziyu Meng ◽  
Rong Guo ◽  
Yudu Li ◽  
Yue Guan ◽  
Tianyao Wang ◽  
...  
2020 ◽  
Vol 31 (6) ◽  
pp. 681-689
Author(s):  
Jalal Mirakhorli ◽  
Hamidreza Amindavar ◽  
Mojgan Mirakhorli

AbstractFunctional magnetic resonance imaging a neuroimaging technique which is used in brain disorders and dysfunction studies, has been improved in recent years by mapping the topology of the brain connections, named connectopic mapping. Based on the fact that healthy and unhealthy brain regions and functions differ slightly, studying the complex topology of the functional and structural networks in the human brain is too complicated considering the growth of evaluation measures. One of the applications of irregular graph deep learning is to analyze the human cognitive functions related to the gene expression and related distributed spatial patterns. Since a variety of brain solutions can be dynamically held in the neuronal networks of the brain with different activity patterns and functional connectivity, both node-centric and graph-centric tasks are involved in this application. In this study, we used an individual generative model and high order graph analysis for the region of interest recognition areas of the brain with abnormal connection during performing certain tasks and resting-state or decompose irregular observations. Accordingly, a high order framework of Variational Graph Autoencoder with a Gaussian distributer was proposed in the paper to analyze the functional data in brain imaging studies in which Generative Adversarial Network is employed for optimizing the latent space in the process of learning strong non-rigid graphs among large scale data. Furthermore, the possible modes of correlations were distinguished in abnormal brain connections. Our goal was to find the degree of correlation between the affected regions and their simultaneous occurrence over time. We can take advantage of this to diagnose brain diseases or show the ability of the nervous system to modify brain topology at all angles and brain plasticity according to input stimuli. In this study, we particularly focused on Alzheimer’s disease.


2021 ◽  
Vol 11 (11) ◽  
pp. 4922
Author(s):  
Tengfei Ma ◽  
Wentian Chen ◽  
Xin Li ◽  
Yuting Xia ◽  
Xinhua Zhu ◽  
...  

To explore whether the brain contains pattern differences in the rock–paper–scissors (RPS) imagery task, this paper attempts to classify this task using fNIRS and deep learning. In this study, we designed an RPS task with a total duration of 25 min and 40 s, and recruited 22 volunteers for the experiment. We used the fNIRS acquisition device (FOIRE-3000) to record the cerebral neural activities of these participants in the RPS task. The time series classification (TSC) algorithm was introduced into the time-domain fNIRS signal classification. Experiments show that CNN-based TSC methods can achieve 97% accuracy in RPS classification. CNN-based TSC method is suitable for the classification of fNIRS signals in RPS motor imagery tasks, and may find new application directions for the development of brain–computer interfaces (BCI).


Author(s):  
Jingyan Qiu ◽  
Linjian Li ◽  
Yida Liu ◽  
Yingjun Ou ◽  
Yubei Lin

Alzheimer’s disease (AD) is one of the most common forms of dementia. The early stage of the disease is defined as Mild Cognitive Impairment (MCI). Recent research results have shown the prospect of combining Magnetic Resonance Imaging (MRI) scanning of the brain and deep learning to diagnose AD. However, the CNN deep learning model requires a large scale of samples for training. Transfer learning is the key to enable a model with high accuracy by using limited data for training. In this paper, DenseNet and Inception V4, which were pre-trained on the ImageNet dataset to obtain initialization values of weights, are, respectively, used for the graphic classification task. The ensemble method is employed to enhance the effectiveness and efficiency of the classification models and the result of different models are eventually processed through probability-based fusion. Our experiments were completely conducted on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) public dataset. Only the ternary classification is made due to a higher demand for medical detection and diagnosis. The accuracies of AD/MCI/Normal Control (NC) of different models are estimated in this paper. The results of the experiments showed that the accuracies of the method achieved a maximum of 92.65%, which is a remarkable outcome compared with the accuracies of the state-of-the-art methods.


Author(s):  
Thomas P. Trappenberg

This chapter discusses the basic operation of an artificial neural network which is the major paradigm of deep learning. The name derives from an analogy to a biological brain. The discussion begins by outlining the basic operations of neurons in the brain and how these operations are abstracted by simple neuron models. It then builds networks of artificial neurons that constitute much of the recent success of AI. The focus of this chapter is on using such techniques, with subsequent consideration of their theoretical embedding.


2020 ◽  
Vol 21 (S6) ◽  
Author(s):  
Jianqiang Li ◽  
Guanghui Fu ◽  
Yueda Chen ◽  
Pengzhi Li ◽  
Bo Liu ◽  
...  

Abstract Background Screening of the brain computerised tomography (CT) images is a primary method currently used for initial detection of patients with brain trauma or other conditions. In recent years, deep learning technique has shown remarkable advantages in the clinical practice. Researchers have attempted to use deep learning methods to detect brain diseases from CT images. Methods often used to detect diseases choose images with visible lesions from full-slice brain CT scans, which need to be labelled by doctors. This is an inaccurate method because doctors detect brain disease from a full sequence scan of CT images and one patient may have multiple concurrent conditions in practice. The method cannot take into account the dependencies between the slices and the causal relationships among various brain diseases. Moreover, labelling images slice by slice spends much time and expense. Detecting multiple diseases from full slice brain CT images is, therefore, an important research subject with practical implications. Results In this paper, we propose a model called the slice dependencies learning model (SDLM). It learns image features from a series of variable length brain CT images and slice dependencies between different slices in a set of images to predict abnormalities. The model is necessary to only label the disease reflected in the full-slice brain scan. We use the CQ500 dataset to evaluate our proposed model, which contains 1194 full sets of CT scans from a total of 491 subjects. Each set of data from one subject contains scans with one to eight different slice thicknesses and various diseases that are captured in a range of 30 to 396 slices in a set. The evaluation results present that the precision is 67.57%, the recall is 61.04%, the F1 score is 0.6412, and the areas under the receiver operating characteristic curves (AUCs) is 0.8934. Conclusion The proposed model is a new architecture that uses a full-slice brain CT scan for multi-label classification, unlike the traditional methods which only classify the brain images at the slice level. It has great potential for application to multi-label detection problems, especially with regard to the brain CT images.


2020 ◽  
Vol 38 (1) ◽  
pp. 49-64 ◽  
Author(s):  
Hiroshi Yamakawa

AbstractRecently, attention mechanisms have significantly boosted the performance of natural language processing using deep learning. An attention mechanism can select the information to be used, such as by conducting a dictionary lookup; this information is then used, for example, to select the next utterance word in a sentence. In neuroscience, the basis of the function of sequentially selecting words is considered to be the cortico-basal ganglia-thalamocortical loop. Here, we first show that the attention mechanism used in deep learning corresponds to the mechanism in which the cerebral basal ganglia suppress thalamic relay cells in the brain. Next, we demonstrate that, in neuroscience, the output of the basal ganglia is associated with the action output in the actor of reinforcement learning. Based on these, we show that the aforementioned loop can be generalized as reinforcement learning that controls the transmission of the prediction signal so as to maximize the prediction reward. We call this attentional reinforcement learning (ARL). In ARL, the actor selects the information transmission route according to the attention, and the prediction signal changes according to the context detected by the information source of the route. Hence, ARL enables flexible action selection that depends on the situation, unlike traditional reinforcement learning, wherein the actor must directly select an action.


2020 ◽  
Vol 17 (4) ◽  
pp. 1925-1930
Author(s):  
Ambeshwar Kumar ◽  
R. Manikandan ◽  
Robbi Rahim

It’s a new era technology in the field of medical engineering giving awareness about the various healthcare features. Deep learning is a part of machine learning, it is capable of handling high dimensional data and is efficient in concentrating on the right features. Tumor is an unbelievably complex disease: a multifaceted cell has more than hundred billion cells; each cell acquires mutation exclusively. Detection of tumor particles in experiment is easily done by MRI or CT. Brain tumors can also be detected by MRI, however, deep learning techniques give a better approach to segment the brain tumor images. Deep Learning models are imprecisely encouraged by information handling and communication designs in biological nervous system. Classification plays an significant role in brain tumor detection. Neural network is creating a well-organized rule for classification. To accomplish medical image data, neural network is trained to use the Convolution algorithm. Multilayer perceptron is intended for identification of a image. In this study article, the brain images are categorized into two types: normal and abnormal. This article emphasize the importance of classification and feature selection approach for predicting the brain tumor. This classification is done by machine learning techniques like Artificial Neural Networks, Support Vector Machine and Deep Neural Network. It could be noted that more than one technique can be applied for the segmentation of tumor. The several samples of brain tumor images are classified using deep learning algorithms, convolution neural network and multi-layer perceptron.


2020 ◽  
Vol 25 (Supplement_2) ◽  
pp. e25-e25
Author(s):  
Sarah MacEachern ◽  
Deepthi Rajashekar ◽  
Pauline Mouches ◽  
Nathan Rowe ◽  
Emily Mckenna ◽  
...  

Abstract Introduction/Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder resulting in challenges with social communication, sensory differences, and repetitive and restricted patterns of behavior. ASD affects approximately 1 in 66 children in North America, with boys being affected four times more frequently than girls. Currently, diagnosis is made primarily based on clinical features and no robust biomarker for ASD diagnosis has been identified. Potential image-based biomarkers to aid ASD diagnosis may include structural properties of deep gray matter regions in the brain. Objectives The primary objective of this work was to investigate if children with ASD show micro- and macrostructural alterations in deep gray matter structures compared to neurotypical children, and if these biomarkers can be used for an automatic ASD classification using deep learning. Design/Methods Quantitative apparent diffusion coefficient (ADC) magnetic resonance imaging data was obtained from 23 boys with ASD ages 0.8 – 19.6 years (mean 7.6 years) and 39 neurotypical boys ages 0.3 – 17.75 years (mean 7.6 years). An atlas-based method was used for volumetric analysis and extraction of median ADC values for each subject within the cerebral cortex, hippocampus, thalamus, caudate, putamen, globus pallidus, amygdala, and nucleus accumbens. The extracted quantitative regional volumetric and median ADC values were then used for the development and evaluation of an automatic classification method using an artificial neural network. Results The classification model was evaluated using 10-fold cross validation resulting in an overall accuracy of 76%, which is considerably better than chance level (62%). Specifically, 33 neurotypical boys were correctly classified, whereas 6 neurotypical boys were incorrectly classified. For the ASD group, 14 boys were correctly classified, while 9 boys were incorrectly classified. This translates to a precision of 70% for the children with ASD and 79% for neurotypical boys. Conclusion To the best of our knowledge, this is the first method to classify children with ASD using micro- and macrostructural properties of deep gray matter structures in the brain. The first results of the proposed deep learning method to identify children with ASD using image-based biomarkers are promising and could serve as the platform to create a more accurate and robust deep learning model for clinical application.


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