Evaluation of renal ischemia‐reperfusion injury by magnetic resonance imaging texture analysis: An experimental study

2020 ◽  
Vol 85 (1) ◽  
pp. 346-356
Author(s):  
Liang Pan ◽  
Jie Chen ◽  
Tingting Zha ◽  
Liqiu Zou ◽  
Jinggang Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Experimental Study ◽  
Magnetic Resonance ◽  
Reperfusion Injury ◽  
Texture Analysis ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Resonance Imaging ◽  
Renal Ischemia Reperfusion Injury

389 PRETREATMENT WITH VARDENAFIL ATTENUATES RENAL ISCHEMIA-REPERFUSION INJURY. AN EXPERIMENTAL STUDY IN RATS

2011 ◽  
Vol 185 (4S) ◽  
Author(s):  
Iason Kyriazis ◽  
Panagiotis Kallidonis ◽  
Odysseas Andrikopoulos ◽  
Despoina Liourdi ◽  
Helen Papadaki ◽  
...  
Keyword(s):  
Experimental Study ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Renal Ischemia Reperfusion Injury

scholarly journals Noninvasive Assessment of Fibrosis Following Ischemia/Reperfusion Injury in Rodents Utilizing Na Magnetic Resonance Imaging

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 775
Author(s):  
Per Mose Nielsen ◽  
Christian Østergaard Mariager ◽  
Daniel Guldager Kring Rasmussen ◽  
Marie Mølmer ◽  
Federica Genovese ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
T2 Mapping ◽  
Ischemia Reperfusion ◽  
Quantitative Polymerase Chain Reaction ◽  
Type Iii Collagen ◽  
Resonance Imaging ◽  
Dce Mri

Fibrosis is often heterogeneously distributed, and classical biopsies do not reflect this. Noninvasive methods for renal fibrosis have been developed to follow chronic kidney diseases (CKD) and to monitor anti-fibrotic therapy. In this study, we combined two approaches to assess fibrosis regression following renal ischemia-reperfusion injury (IRI): magnetic resonance imaging (MRI) and noninvasive extracellular matrix (ECM) biomarkers. MRI was used to evaluate fibrosis in bilateral IRI in rats after reperfusion at 7, 14, and 21 days. This was performed with 1HT1 and T2* mapping, dynamic contrast-enhanced (DCE)-MRI, and chemical shift imaging (CSI)-23Na. The degradation of laminin gamma-1 chain (LG1M) and type III collagen (C3M) was measured in urine and plasma. Fibrosis was analyzed in tissue using fibronectin (FN) and alpha-smooth muscle actin (α-SMA) using quantitative polymerase chain reaction qPCR and western blotting. We found increased fibrosis 7 days after reperfusion, which dropped to sham levels after 21 days. Single kidney glomerular filtration rate (skGFR), perfusion (DCE-MRI), and total 23Na kidney content correlated positively with fibrotic markers FN and α-SMA as well as noninvasive LG1M and C3M. We showed that novel MRI protocols and ECM markers could track fibrogenic development. This could give rise to a multi-parametric practice to diagnose and assess fibrosis whilst treating kidney disease without using invasive methods.

Renoprotective Effect of Humic Acid on Renal Ischemia-Reperfusion Injury: An Experimental Study in Rats

Inflammation ◽  
2015 ◽  
Vol 38 (6) ◽  
pp. 2042-2048 ◽  
Author(s):  
Alpaslan Akbas ◽  
Coskun Silan ◽  
Murat Tolga Gulpinar ◽  
Eyup Burak Sancak ◽  
Sidika Seyma Ozkanli ◽  
...  
Keyword(s):  
Experimental Study ◽  
Humic Acid ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Renal Ischemia ◽  
Renoprotective Effect ◽  
Renal Ischemia Reperfusion Injury
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