Quantitative evaluation of lung injury caused by PM 2.5 using hyperpolarized gas magnetic resonance

2019 ◽  
Vol 84 (2) ◽  
pp. 569-578 ◽  
Author(s):  
Ming Zhang ◽  
Haidong Li ◽  
Hongchuang Li ◽  
Xiuchao Zhao ◽  
Qian Zhou ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Lung Injury ◽  
Quantitative Evaluation ◽  
Pm 2.5 ◽  
Hyperpolarized Gas

Quantitative evaluation of radiation-induced lung injury with hyperpolarized xenon magnetic resonance

2015 ◽  
Vol 76 (2) ◽  
pp. 408-416 ◽  
Author(s):  
Haidong Li ◽  
Zhiying Zhang ◽  
Xiuchao Zhao ◽  
Xianping Sun ◽  
Chaohui Ye ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Lung Injury ◽  
Quantitative Evaluation ◽  
Hyperpolarized Xenon ◽  
Radiation Induced

scholarly journals Magnetic resonance imaging provides sensitive in vivo assessment of experimental ventilator-induced lung injury

2016 ◽  
Vol 311 (2) ◽  
pp. L208-L218 ◽  
Author(s):  
Dean O. Kuethe ◽  
Piotr T. Filipczak ◽  
Jeremy M. Hix ◽  
Andrew P. Gigliotti ◽  
Raúl San José Estépar ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Lung Injury ◽  
Real Time ◽  
Critical Role ◽  
Lung Mechanics ◽  
Therapeutic Effects ◽  
Resonance Imaging ◽  
Ventilator Induced Lung Injury

Animal models play a critical role in the study of acute respiratory distress syndrome (ARDS) and ventilator-induced lung injury (VILI). One limitation has been the lack of a suitable method for serial assessment of acute lung injury (ALI) in vivo. In this study, we demonstrate the sensitivity of magnetic resonance imaging (MRI) to assess ALI in real time in rat models of VILI. Sprague-Dawley rats were untreated or treated with intratracheal lipopolysaccharide or PBS. After 48 h, animals were mechanically ventilated for up to 15 h to induce VILI. Free induction decay (FID)-projection images were made hourly. Image data were collected continuously for 30 min and divided into 13 phases of the ventilatory cycle to make cinematic images. Interleaved measurements of respiratory mechanics were performed using a flexiVent ventilator. The degree of lung infiltration was quantified in serial images throughout the progression or resolution of VILI. MRI detected VILI significantly earlier (3.8 ± 1.6 h) than it was detected by altered lung mechanics (9.5 ± 3.9 h, P = 0.0156). Animals with VILI had a significant increase in the Index of Infiltration ( P = 0.0027), and early regional lung infiltrates detected by MRI correlated with edema and inflammatory lung injury on histopathology. We were also able to visualize and quantify regression of VILI in real time upon institution of protective mechanical ventilation. Magnetic resonance lung imaging can be utilized to investigate mechanisms underlying the development and propagation of ALI, and to test the therapeutic effects of new treatments and ventilator strategies on the resolution of ALI.

Hyperpolarized Gas Magnetic Resonance Imaging of Pediatric Cystic Fibrosis Lung Disease

2019 ◽  
Vol 26 (3) ◽  
pp. 344-354 ◽  
Author(s):  
Giles Santyr ◽  
Nikhil Kanhere ◽  
Felipe Morgado ◽  
Jonathan H. Rayment ◽  
Felix Ratjen ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Cystic Fibrosis ◽  
Magnetic Resonance ◽  
Lung Disease ◽  
Cystic Fibrosis Lung ◽  
Resonance Imaging ◽  
Hyperpolarized Gas ◽  
Cystic Fibrosis Lung Disease
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