scholarly journals Prospective frequency correction using outer volume suppression-localized navigator for MR spectroscopy and spectroscopic imaging

2018 ◽  
Vol 80 (6) ◽  
pp. 2366-2373 ◽  
Author(s):  
Chu-Yu Lee ◽  
In-Young Choi ◽  
Phil Lee
Keyword(s):  
Mr Spectroscopy ◽  
Spectroscopic Imaging ◽  
Outer Volume Suppression ◽  
Frequency Correction

scholarly journals Automatic placement of outer volume suppression slices in MR spectroscopic imaging of the human brain

2010 ◽  
Vol 63 (3) ◽  
pp. 592-600 ◽  
Author(s):  
Manel Martínez-Ramón ◽  
Ascensión Gallardo-Antolín ◽  
Jesús Cid-Sueiro ◽  
Gregory L. Heileman ◽  
Kaung-Ti Yung ◽  
...  
Keyword(s):  
Human Brain ◽  
Spectroscopic Imaging ◽  
Outer Volume Suppression ◽  
Automatic Placement ◽  
Mr Spectroscopic Imaging

scholarly journals Proton MR Spectroscopic Imaging in Pelizaeus-Merzbacher Disease

2003 ◽  
Vol 16 (3) ◽  
pp. 449-450 ◽  
Author(s):  
F. Pizzini ◽  
A. Fatemi ◽  
P.B. Barker ◽  
H.W. Moser ◽  
S. Naidu ◽  
...  
Keyword(s):  
Mr Spectroscopy ◽  
Phenotypic Expression ◽  
Gene Mutations ◽  
Spectroscopic Imaging ◽  
Chromosome X ◽  
Pelizaeus Merzbacher Disease ◽  
Mr Spectroscopic Imaging

We describe the MR spectroscopy findings in three patients with Pelizaeus-Merzbacker disease, a rare leukodystrophy associated with mutations of the PLP gene on chromosome X. The patients studied had different PLP gene mutations and presented different metabolic patterns, indicating a different phenotypic expression of mutations of the same gene.

scholarly journals Atlas-based automated positioning of outer volume suppression slices in short-echo time 3D MR spectroscopic imaging of the human brain

2011 ◽  
Vol 66 (4) ◽  
pp. 911-922 ◽  
Author(s):  
Kaung-Ti Yung ◽  
Weili Zheng ◽  
Chenguang Zhao ◽  
Manel Martínez-Ramón ◽  
André van der Kouwe ◽  
...  
Keyword(s):  
Human Brain ◽  
Spectroscopic Imaging ◽  
Outer Volume Suppression ◽  
Echo Time ◽  
Short Echo Time ◽  
Mr Spectroscopic Imaging

Proton MR spectroscopy in patients with pyogenic brain abscess: MR spectroscopic imaging versus single-voxel spectroscopy

2013 ◽  
Vol 82 (8) ◽  
pp. 1299-1307 ◽  
Author(s):  
Shuo-Hsiu Hsu ◽  
Ming-Chung Chou ◽  
Cheng-Wen Ko ◽  
Shu-Shong Hsu ◽  
Huey-Shyan Lin ◽  
...  
Keyword(s):  
Brain Abscess ◽  
Mr Spectroscopy ◽  
Spectroscopic Imaging ◽  
Proton Mr Spectroscopy ◽  
Single Voxel ◽  
Mr Spectroscopic Imaging

Automated spectral analysis III: Application toin Vivo proton MR Spectroscopy and spectroscopic imaging

1998 ◽  
Vol 40 (6) ◽  
pp. 822-831 ◽  
Author(s):  
Brian J. Soher ◽  
Karl Young ◽  
Varanavasi Govindaraju ◽  
Andrew A. Maudsley
Keyword(s):  
Spectral Analysis ◽  
Mr Spectroscopy ◽  
Spectroscopic Imaging ◽  
Proton Mr Spectroscopy ◽  
Automated Spectral Analysis

scholarly journals Monitoring tumor cell death in murine tumor models using deuterium magnetic resonance spectroscopy and spectroscopic imaging

2021 ◽  
Vol 118 (12) ◽  
pp. e2014631118
Author(s):  
Friederike Hesse ◽  
Vencel Somai ◽  
Felix Kreis ◽  
Flaviu Bulat ◽  
Alan J. Wright ◽  
...  
Keyword(s):  
Cell Death ◽  
Magnetic Resonance ◽  
Drug Treatment ◽  
Tumor Cell ◽  
Mr Spectroscopy ◽  
Spectroscopic Imaging ◽  
Metabolic Imaging ◽  
Resonance Spectroscopy ◽  
Tumor Cell Death

2H magnetic resonance spectroscopic imaging has been shown recently to be a viable technique for metabolic imaging in the clinic. We show here that 2H MR spectroscopy and spectroscopic imaging measurements of [2,3-2H2]malate production from [2,3-2H2]fumarate can be used to detect tumor cell death in vivo via the production of labeled malate. Production of [2,3-2H2]malate, following injection of [2,3-2H2]fumarate (1 g/kg) into tumor-bearing mice, was measured in a murine lymphoma (EL4) treated with etoposide, and in human breast (MDA-MB-231) and colorectal (Colo205) xenografts treated with a TRAILR2 agonist, using surface-coil localized 2H MR spectroscopy at 7 T. Malate production was also imaged in EL4 tumors using a fast 2H chemical shift imaging sequence. The malate/fumarate ratio increased from 0.016 ± 0.02 to 0.16 ± 0.14 in EL4 tumors 48 h after drug treatment (P = 0.0024, n = 3), and from 0.019 ± 0.03 to 0.25 ± 0.23 in MDA-MB-231 tumors (P = 0.0001, n = 5) and from 0.016 ± 0.04 to 0.28 ± 0.26 in Colo205 tumors (P = 0.0002, n = 5) 24 h after drug treatment. These increases were correlated with increased levels of cell death measured in excised tumor sections obtained immediately after imaging. 2H MR measurements of [2,3-2H2]malate production from [2,3-2H2]fumarate provide a potentially less expensive and more sensitive method for detecting cell death in vivo than 13C MR measurements of hyperpolarized [1,4-13C2]fumarate metabolism, which have been used previously for this purpose.

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