scholarly journals Quantitative susceptibility mapping of articular cartilage: Ex vivo findings at multiple orientations and following different degradation treatments

2018 ◽  
Vol 80 (6) ◽  
pp. 2702-2716 ◽  
Author(s):  
Olli Nykänen ◽  
Lassi Rieppo ◽  
Juha Töyräs ◽  
Ville Kolehmainen ◽  
Simo Saarakkala ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Ex Vivo ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping

IC-P-145: EX-VIVO QUANTITATIVE SUSCEPTIBILITY MAPPING (QSM) IN A COMMUNITY COHORT REVEALS LINK BETWEEN MAGNETIC SUSCEPTIBILITY AND ALZHEIMER'S PATHOLOGY

2014 ◽  
Vol 10 ◽  
pp. P83-P84
Author(s):  
Arnold Moya Evia ◽  
Konstantinos Arfanakis ◽  
David Bennett ◽  
Julie Schneider ◽  
Aikaterini Kotrotsou ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Ex Vivo ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Alzheimer’S Pathology

scholarly journals Quantitative susceptibility mapping of articular cartilage in patients with osteoarthritis at 3T

2018 ◽  
Vol 49 (6) ◽  
pp. 1665-1675 ◽  
Author(s):  
Hongjiang Wei ◽  
Huimin Lin ◽  
Le Qin ◽  
Steven Cao ◽  
Yuyao Zhang ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping

scholarly journals Ex-vivo quantitative susceptibility mapping of human brain hemispheres

PLoS ONE ◽  
2017 ◽  
Vol 12 (12) ◽  
pp. e0188395 ◽  
Author(s):  
Arnold M. Evia ◽  
Aikaterini Kotrotsou ◽  
Ashish A. Tamhane ◽  
Robert J. Dawe ◽  
Alifiya Kapasi ◽  
...  
Keyword(s):  
Human Brain ◽  
Ex Vivo ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Brain Hemispheres

EX VIVO QUANTITATIVE SUSCEPTIBILITY MAPPING (QSM) IN A COMMUNITY COHORT REVEALS LINK BETWEEN MAGNETIC SUSCEPTIBILITY AND ALZHEIMER'S PATHOLOGY

2014 ◽  
Vol 10 ◽  
pp. P549-P550
Author(s):  
Arnold Moya Evia ◽  
Konstantinos Arfanakis ◽  
David Bennett ◽  
Julie Schneider ◽  
Aikaterini Kotrotsou ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Ex Vivo ◽  
Susceptibility Mapping ◽  
Quantitative Susceptibility Mapping ◽  
Alzheimer’S Pathology

scholarly journals Quantitative susceptibility mapping of carotid arterial tissue ex vivo: assessing sensitivity to vessel microstructural composition

2021 ◽  
Author(s):  
Alan J. Stone ◽  
Brooke Tornifoglio ◽  
Robert D. Johnston ◽  
Karin Shmueli ◽  
Christian Kerskens ◽  
...  
Keyword(s):  
Magnetic Susceptibility ◽  
Carotid Arteries ◽  
Ex Vivo ◽  
Enzymatic Digestion ◽  
Susceptibility Mapping ◽  
Specific Marker ◽  
Quantitative Susceptibility Mapping ◽  
Healthy Human ◽  
Significant Difference ◽  
Arterial Tissue

AbstractPurposeTo characterise microstructural contributions to the magnetic susceptibility of carotid arteries.MethodArterial vessels were scanned using high resolution quantitative susceptibility mapping (QSM) at 7T. Models of vessel degradation were generated using ex vivo porcine carotid arteries that were subjected to several different enzymatic digestion treatments that selectively removed microstructural components (smooth muscle cells, collagen and elastin). Magnetic susceptibilities measured in these tissue models were compared to those in untreated (native) porcine arteries. Magnetic susceptibility measured in native porcine carotid arteries was further compared to the susceptibility of cadaveric human carotid arteries to investigate their similarity.ResultsThe magnetic susceptibility of native porcine vessels was diamagnetic (𝒳native = −0.1820ppm), with higher susceptibilities in all models of vessel degradation (𝒳elastin degraded = −0.0163ppm; 𝒳collagen degraded = −0.1158ppm; 𝒳decellularised = −0.1379ppm; 𝒳fixed native = −0.2199ppm). Magnetic susceptibility was significantly higher in collagen degraded compared to native porcine vessels (Tukey-Kramer, p<0.01) and between elastin degraded and all other models (including native, Tukey-Kramer, p<0.001). The susceptibility of fixed healthy human arterial tissue was diamagnetic and no significant difference was found between fixed human and fixed porcine arterial tissue susceptibilities (ANOVA, p>0.05).ConclusionsMagnetic susceptibility measured using QSM is sensitive to the microstructural composition of arterial vessels – most notably to collagen. The similarity of human and porcine arterial tissue susceptibility values provides a solid basis for translational studies. As vessel microstructure becomes disrupted during the onset and progression of carotid atherosclerosis, QSM has the potential to provide a sensitive and specific marker of vessel disease.

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