scholarly journals Optimization of selective inversion recovery magnetization transfer imaging for macromolecular content mapping in the human brain

2018 ◽  
Vol 80 (5) ◽  
pp. 1824-1835 ◽  
Author(s):  
Richard D. Dortch ◽  
Francesca Bagnato ◽  
Daniel F. Gochberg ◽  
John C. Gore ◽  
Seth A. Smith
Keyword(s):  
Human Brain ◽  
Magnetization Transfer ◽  
Inversion Recovery ◽  
Magnetization Transfer Imaging ◽  
Selective Inversion ◽  
Macromolecular Content

scholarly journals Quantitative magnetization transfer imaging in human brain at 3 T via selective inversion recovery

2011 ◽  
Vol 66 (5) ◽  
pp. 1346-1352 ◽  
Author(s):  
Richard D. Dortch ◽  
Ke Li ◽  
Daniel F. Gochberg ◽  
E. Brian Welch ◽  
Adrienne N. Dula ◽  
...  
Keyword(s):  
Human Brain ◽  
Magnetization Transfer ◽  
Inversion Recovery ◽  
Magnetization Transfer Imaging ◽  
Selective Inversion

scholarly journals Rapid whole-brain quantitative magnetization transfer imaging using 3D selective inversion recovery sequences

2020 ◽  
Vol 68 ◽  
pp. 66-74 ◽  
Author(s):  
Matthew J. Cronin ◽  
Junzhong Xu ◽  
Francesca Bagnato ◽  
Daniel F. Gochberg ◽  
John C. Gore ◽  
...  
Keyword(s):  
Magnetization Transfer ◽  
Inversion Recovery ◽  
Magnetization Transfer Imaging ◽  
Whole Brain ◽  
Selective Inversion

scholarly journals Quantitative magnetization transfer imaging of rodent glioma using selective inversion recovery

2013 ◽  
Vol 27 (3) ◽  
pp. 253-260 ◽  
Author(s):  
Junzhong Xu ◽  
Ke Li ◽  
Zhongliang Zu ◽  
Xia Li ◽  
Daniel F. Gochberg ◽  
...  
Keyword(s):  
Magnetization Transfer ◽  
Inversion Recovery ◽  
Magnetization Transfer Imaging ◽  
Selective Inversion ◽  
Rodent Glioma

scholarly journals Quantitative magnetization transfer imaging of human brain at 7T

NeuroImage ◽  
2013 ◽  
Vol 64 ◽  
pp. 640-649 ◽  
Author(s):  
Richard D. Dortch ◽  
Jay Moore ◽  
Ke Li ◽  
Marcin Jankiewicz ◽  
Daniel F. Gochberg ◽  
...  
Keyword(s):  
Human Brain ◽  
Magnetization Transfer ◽  
Magnetization Transfer Imaging

scholarly journals Selective inversion recovery quantitative magnetization transfer imaging: Toward a 3 T clinical application in multiple sclerosis

2019 ◽  
Vol 26 (4) ◽  
pp. 457-467 ◽  
Author(s):  
Francesca Bagnato ◽  
Giulia Franco ◽  
Fei Ye ◽  
Run Fan ◽  
Patricia Commiskey ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Brain Mri ◽  
Inversion Recovery ◽  
Clinical Disease ◽  
Normal Appearing White Matter ◽  
Selective Inversion ◽  
Pool Model ◽  
Magnetic Resonance Imaging Mri

Background:Assessing the degree of myelin injury in patients with multiple sclerosis (MS) is challenging due to the lack of magnetic resonance imaging (MRI) methods specific to myelin quantity. By measuring distinct tissue parameters from a two-pool model of the magnetization transfer (MT) effect, quantitative magnetization transfer (qMT) may yield these indices. However, due to long scan times, qMT has not been translated clinically.Objectives:We aim to assess the clinical feasibility of a recently optimized selective inversion recovery (SIR) qMT and to test the hypothesis that SIR-qMT-derived metrics are informative of radiological and clinical disease-related changes in MS.Methods:A total of 18 MS patients and 9 age- and sex-matched healthy controls (HCs) underwent a 3.0 Tesla (3 T) brain MRI, including clinical scans and an optimized SIR-qMT protocol. Four subjects were re-scanned at a 2-week interval to determine inter-scan variability.Results:SIR-qMT measures differed between lesional and non-lesional tissue ( p < 0.0001) and between normal-appearing white matter (NAWM) of patients with more advanced disability and normal white matter (WM) of HCs ( p < 0.05). SIR-qMT measures were associated with lesion volumes, disease duration, and disability scores ( p ⩽ 0.002).Conclusion:SIR-qMT at 3 T is clinically feasible and predicts both radiological and clinical disease severity in MS.

scholarly journals Selective Inversion Recovery Quantitative Magnetization Transfer Brain MRI at 7T: Clinical and Postmortem Validation in Multiple Sclerosis

2018 ◽  
Vol 28 (4) ◽  
pp. 380-388 ◽  
Author(s):  
Francesca Bagnato ◽  
Simon Hametner ◽  
Giulia Franco ◽  
Siddharama Pawate ◽  
Subramaniam Sriram ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Magnetization Transfer ◽  
Brain Mri ◽  
Inversion Recovery ◽  
Selective Inversion

scholarly journals Optimized inversion recovery sequences for quantitative T 1 and magnetization transfer imaging

2010 ◽  
Vol 64 (2) ◽  
pp. 491-500 ◽  
Author(s):  
Ke Li ◽  
Zhongliang Zu ◽  
Junzhong Xu ◽  
Vaibhav A. Janve ◽  
John C. Gore ◽  
...  
Keyword(s):  
Magnetization Transfer ◽  
Inversion Recovery ◽  
Magnetization Transfer Imaging

scholarly journals Inversion‐recovery MR elastography of the human brain for improved stiffness quantification near fluid–solid boundaries

2021 ◽  
Author(s):  
Ledia Lilaj ◽  
Helge Herthum ◽  
Tom Meyer ◽  
Mehrgan Shahryari ◽  
Gergely Bertalan ◽  
...  
Keyword(s):  
Human Brain ◽  
Inversion Recovery ◽  
Mr Elastography
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