scholarly journals Assessment of MR‐based and quantitative susceptibility mapping for the quantification of liver iron concentration in a mouse model at 7T

2018 ◽  
Vol 80 (5) ◽  
pp. 2081-2093 ◽  
Author(s):  
Gregory Simchick ◽  
Zhi Liu ◽  
Tamas Nagy ◽  
May Xiong ◽  
Qun Zhao
Keyword(s):  
Mouse Model ◽  
Iron Concentration ◽  
Susceptibility Mapping ◽  
Liver Iron Concentration ◽  
Quantitative Susceptibility Mapping ◽  
Liver Iron

scholarly journals The Oral Ferroportin Inhibitor VIT-2763 Improves Erythropoiesis without Interfering with Iron Chelation Therapy in a Mouse Model of β-Thalassemia

2021 ◽  
Vol 22 (2) ◽  
pp. 873
Author(s):  
Naja Nyffenegger ◽  
Anna Flace ◽  
Cédric Doucerain ◽  
Franz Dürrenberger ◽  
Vania Manolova
Keyword(s):  
Mouse Model ◽  
Iron Overload ◽  
Chelation Therapy ◽  
Iron Concentration ◽  
Transferrin Saturation ◽  
Iron Chelation ◽  
Iron Chelator ◽  
Liver Iron Concentration ◽  
Ineffective Erythropoiesis ◽  
Liver Iron

In β-thalassemia, ineffective erythropoiesis leads to anemia and systemic iron overload. The management of iron overload by chelation therapy is a standard of care. However, iron chelation does not improve the ineffective erythropoiesis. We recently showed that the oral ferroportin inhibitor VIT-2763 ameliorates anemia and erythropoiesis in the Hbbth3/+ mouse model of β-thalassemia. In this study, we investigated whether concurrent use of the iron chelator deferasirox (DFX) and the ferroportin inhibitor VIT-2763 causes any pharmacodynamic interactions in the Hbbth3/+ mouse model of β-thalassemia. Mice were treated with VIT-2763 or DFX alone or with the combination of both drugs once daily for three weeks. VIT-2763 alone or in combination with DFX improved anemia and erythropoiesis. VIT-2763 alone decreased serum iron and transferrin saturation (TSAT) but was not able to reduce the liver iron concentration. While DFX alone had no effect on TSAT and erythropoiesis, it significantly reduced the liver iron concentration alone and in the presence of VIT-2763. Our results clearly show that VIT-2763 does not interfere with the iron chelation efficacy of DFX. Furthermore, VIT-2763 retains its beneficial effects on improving ineffective erythropoiesis when combined with DFX in the Hbbth3/+ mouse model. In conclusion, co-administration of the oral ferroportin inhibitor VIT-2763 and the iron chelator DFX is feasible and might offer an opportunity to improve both ineffective erythropoiesis and iron overload in β-thalassemia.

Liver iron concentration and fibrosis in a cohort of transfusion-dependent patients on long-term desferrioxamine therapy

2005 ◽  
Vol 5 (7) ◽  
pp. 572-578 ◽  
Author(s):  
Vasili Berdoukas ◽  
Timothy Bohane ◽  
Vivienne Tobias ◽  
Keshani De Silva ◽  
Ian Fraser ◽  
...  
Keyword(s):  
Iron Concentration ◽  
Liver Iron Concentration ◽  
Liver Iron ◽  
Desferrioxamine Therapy

scholarly journals Limitations of serum ferritin to predict liver iron concentration responses to deferasirox therapy in patients with transfusion-dependent thalassaemia

2017 ◽  
Vol 98 (3) ◽  
pp. 280-288 ◽  
Author(s):  
John B. Porter ◽  
Mohsen Elalfy ◽  
Ali Taher ◽  
Yesim Aydinok ◽  
Szu-Hee Lee ◽  
...  
Keyword(s):  
Serum Ferritin ◽  
Iron Concentration ◽  
Liver Iron Concentration ◽  
Liver Iron

Mineral absorption of diets containing natural carob fiber compared to cellulose, pectin and various combinations of these fibers Absorción de minerales de dietas que contienen fibra natural de algarrobas comparada con celulosa, pectina y varias combinaciones de estas fibras

2000 ◽  
Vol 6 (6) ◽  
pp. 463-471 ◽  
Author(s):  
M.P. Vaquero ◽  
L. Perez-Olleros ◽  
M. Garcia-Cuevas ◽  
M. Veldhuizen ◽  
B. Ruiz-Roso ◽  
...  
Keyword(s):  
Iron Absorption ◽  
Calcium Absorption ◽  
Iron Concentration ◽  
Liver Iron Concentration ◽  
Liver Iron ◽  
Final Body Weight ◽  
Mineral Absorption ◽  
Apparent Absorption ◽  
Zinc Concentrations ◽  
Calcium Magnesium

The influence of the consumption of natural carob fiber (NCF), an insoluble hypocholesterolemic fiber, as the unique dietary fiber or combined with cellulose (CEL) or pectin (PEC), on mineral bioavailability was studied. Six groups of rats were fed for 10 days diets containing 10% CEL, NCF, PEC or CEL+NCF, CEL+PEC and NCF+PEC mixtures at 50%. Food intake was lower with PEC than NCF and CEL+NCF, but final body weight was unaffected. Fecal weight showed significant differ ences in the following order: CEL, NCF, CEL+NCF > CEL+PEC, NCF+PEC > PEC. Percentage of calcium absorption was higher with CEL+PEC and NCF+PEC compared with the rest of fibers. Mag nesium absorption was also significantly enhanced in these two groups compared to NCF (p < 0.0004). Iron absorption did not show variations. Zinc apparent absorption was reduced by PEC, but the NCF+PEC mixture counterbalanced this effect. Liver iron was significantly lower with NCF+PEC than CEL, and liver iron concentration was significantly lower with NCF+PEC compared to CEL+PEC. Liver zinc was significantly higher with CEL+NCF than PEC while liver zinc concentrations were slightly higher with the former (p = 0.05 compared to NCF). The results indicate that NCF, compared to CEL and PEC, did not decrease the efficiency of calcium, magnesium and iron absorption in rats, while compared to PEC it increased zinc apparent absorption. Moreover, by combining NCF with PEC calcium and magnesium, absorptions enhanced in comparison with NCF alone, which was prob ably a result of the combination of soluble and insoluble fibers.

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