scholarly journals Separating fast and slow exchange transfer and magnetization transfer using off-resonance variable-delay multiple-pulse (VDMP) MRI

2018 ◽  
Vol 80 (4) ◽  
pp. 1568-1576 ◽  
Author(s):  
Lin Chen ◽  
Xiang Xu ◽  
Haifeng Zeng ◽  
Kannie W.Y. Chan ◽  
Nirbhay Yadav ◽  
...  
Keyword(s):  
Magnetization Transfer ◽  
Variable Delay ◽  
Multiple Pulse ◽  
Slow Exchange

scholarly journals GlucoCEST imaging with on-resonance variable delay multiple pulse (onVDMP) MRI

2018 ◽  
Vol 81 (1) ◽  
pp. 47-56 ◽  
Author(s):  
Xiang Xu ◽  
Jiadi Xu ◽  
Kannie W.Y. Chan ◽  
Jing Liu ◽  
Huanling Liu ◽  
...  
Keyword(s):  
Variable Delay ◽  
Multiple Pulse

scholarly journals D-Glucose uptake and clearance in the tauopathy Alzheimer’s disease mouse brain detected by on-resonance variable delay multiple pulse MRI

2020 ◽  
pp. 0271678X2094126
Author(s):  
Lin Chen ◽  
Zhiliang Wei ◽  
Kannie WY Chan ◽  
Yuguo Li ◽  
Kapil Suchal ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Glucose Uptake ◽  
Glucose Transporter ◽  
Neurofibrillary Tangle ◽  
Cost Effective ◽  
Variable Delay ◽  
Wild Type ◽  
Multiple Pulse ◽  
Model Of Alzheimer’S Disease

In this study, we applied on-resonance variable delay multiple pulse (onVDMP) MRI to study D-glucose uptake in a mouse model of Alzheimer’s disease (AD) tauopathy and demonstrated its feasibility in discriminating AD mice from wild-type mice. The D-glucose uptake in the cortex of AD mice (1.70 ± 1.33%) was significantly reduced compared to that of wild-type mice (5.42 ± 0.70%, p = 0.0051). Also, a slower D-glucose uptake rate was found in the cerebrospinal fluid (CSF) of AD mice (0.08 ± 0.01 min−1) compared to their wild-type counterpart (0.56 ± 0.1 min−1, p < 0.001), which suggests the presence of an impaired glucose transporter on both blood–brain and blood–CSF barriers of these AD mice. Clearance of D-glucose was observed in the CSF of wild-type mice but not AD mice, which suggests dysfunction of the glymphatic system in the AD mice. The results in this study indicate that onVDMP MRI could be a cost-effective and widely available method for simultaneously evaluating glucose transporter and glymphatic function of AD. This study also suggests that tau protein affects the D-glucose uptake and glymphatic impairment in AD at a time point preceding neurofibrillary tangle pathology.

Magnetization Transfer on T2-weighted Image: Magnetization Transfer Ratios in Normal Brain and CerebralLesions

1998 ◽  
Vol 39 (1) ◽  
pp. 15
Author(s):  
Myung Kwan Lim ◽  
Hong Gee Roh ◽  
Chang Hae Suh ◽  
Young Kook Cho ◽  
Hyung Jin Kim ◽  
...  
Keyword(s):  
Magnetization Transfer ◽  
Normal Brain ◽  
Weighted Image

Control by Pyragas method with variable delay: from simple models to experiments

2014 ◽  
Vol 1 ◽  
pp. 679-682
Author(s):  
Aleksandar Gjurchinovski ◽  
Thomas Jüngling ◽  
Viktor Urumov
Keyword(s):  
Variable Delay ◽  
Simple Models

A Feed-Forward Time Amplifier Using a Phase Detector and Variable Delay Lines

2013 ◽  
Vol E96.C (6) ◽  
pp. 920-922 ◽  
Author(s):  
Kiichi NIITSU ◽  
Naohiro HARIGAI ◽  
Takahiro J. YAMAGUCHI ◽  
Haruo KOBAYASHI
Keyword(s):  
Phase Detector ◽  
Variable Delay ◽  
Delay Lines ◽  
Feed Forward ◽  
Time Amplifier
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