Fast, precise, and accurate myocardial T1 mapping using a radial MOLLI sequence with FLASH readout

2017 ◽  
Vol 79 (3) ◽  
pp. 1387-1398 ◽  
Author(s):  
B. Marty ◽  
B. Coppa ◽  
P.G. Carlier
Keyword(s):  
T1 Mapping ◽  
Molli Sequence ◽  
Myocardial T1

Native T1 Values and Cardiac Involvement in Patients with Thalassemia Major

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 24-25
Author(s):  
Alessia Pepe ◽  
Nicola Martini ◽  
Antonio De Luca ◽  
Vincenzo Positano ◽  
Laura Pistoia ◽  
...  
Keyword(s):  
Iron Overload ◽  
T1 Mapping ◽  
Thalassemia Major ◽  
Clinical Impact ◽  
Cardiac Complications ◽  
Myocardial Iron ◽  
Native T1 ◽  
Molli Sequence ◽  
History Of ◽  
Myocardial T1

Background.The T2* cardiovascular magnetic resonance (CMR) is the gold standard for the non invasive detection of myocardial iron overload (MIO). The native myocardial T1 mapping has been proposed as a complementary tool, thanks to its higher sensitivity in presence of small amounts of iron, but no data are available in literature about its clinical impact. Objective:To explore the clinical impact of T1 mapping for detecting cardiac complications in thalassemia major (TM). Methods.We considered 146 TM patients (87 females, 38.7±11.1 years) consecutively enrolled in the Extension-Myocardial Iron Overload in Thalassemia Network. Three parallel short-axis slices of the left ventricle (LV) were acquired with the Modified Look-Locker Inversion recovery (MOLLI) sequence. The native T1 values in all 16 myocardial segments were obtained and the global value was the mean. Results.Twenty-one patients had an history of cardiac complications: 11 heart failure, 8 arrhythmias (7 supraventricular and 1 ventricular), and 2 pulmonary hyperthension. Patients with cardiac complications had significantly lower global heart T1 values (879.3±121.9 ms vs 963.2±98.5 ms; P<0.0001) (Figure) but comparable T2* values (33.32±11.66 ms vs 37.17±9.15 ms; P=0.116). Cardiac complications were more frequent in the group of patients with reduced global heart T1 value (<928 ms for males and <989 ms for females) compared to the group with normal global heart T1 value (71.4% vs 39.5%; P=0.009). Odds ratio (OR) for cardiac complications was 3.8 (95%CI=1.3-10.9) for patients with reduced global heart T1 value versus patients with normal global heart T1 value. Conclusion:We found out a significant association between decreased native global heart T1 values and a history of cardiac complications, suggesting that an early detection of myocardial iron burden by native T1 can support the clinicians in modifing chelation therapy earlier. Figure Disclosures Pepe: ApoPharma Inc.:Other: no profit support;Bayer:Other: no profit support;Chiesi Farmaceutici S.p.A.:Other: no profit support and speakers' honoraria.Pistoia:Chiesi Farmaceutici S.p.A.:Other: speakers' honoraria.Meloni:Chiesi Farmaceutici S.p.A.:Other: speakers' honoraria.

scholarly journals T1 mapping-derived signature of myocardial involvement in idiopathic inflammatory myopathy compared to acute viral myocarditis: a texture-based analysis

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
E Bollache ◽  
AT Huber ◽  
J Lamy ◽  
E Afari ◽  
TM Bacoyannis ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Texture Analysis ◽  
T1 Mapping ◽  
Inflammatory Myopathy ◽  
Viral Myocarditis ◽  
Texture Features ◽  
Idiopathic Inflammatory Myopathy ◽  
Post Contrast ◽  
Myocardial T1 ◽  
Myocardial Involvement

Abstract Funding Acknowledgements Type of funding sources: None. Background. Recent studies revealed the ability of MRI T1 mapping to characterize myocardial involvement in both idiopathic inflammatory myopathy (IIM) and acute viral myocarditis (AVM), as compared to healthy controls. However, neither myocardial T1 nor T2 maps were able to discriminate between IIM and AVM patients, when considering conventional myocardial mean values and derived indices such as lambda and extracellular volume. Purpose. To investigate the ability of T1 mapping-derived texture analysis to differentiate IIM from AVM. Methods. Forty patients, 20 with IIM (51 ± 17 years, 9 men) and 20 with AVM (34 ± 13 years, 16 men) underwent 1.5T MRI T1 mapping using a modified Look-Locker inversion-recovery sequence before and 15 minutes after injection of a gadolinium contrast agent. After manual delineation of endocardial and epicardial borders and co-registration of all inversion time images, native and post-contrast T1 maps were estimated. Myocardial texture analysis was performed on native T1 maps. Textural features such as: autocorrelation, contrast, dissimilarity, energy and sum entropy were used to build a least squares-based linear regression model. Finally, receiver operating characteristic (ROC) analysis was used to investigate the ability of such texture features score to classify IIM vs. AVM patients, compared to the performance of mean myocardial T1. A Wilcoxon rank-sum test was also used to test difference significance between groups. Results. Both native and post-contrast mean myocardial T1 values were comparable between IIM (native: 1022 ± 43 ms; post-contrast: 319 ± 44 ms) and AVM (1056 ± 59 ms, p = 0.07; 318 ± 35 ms, p = 0.90, respectively) groups. Results of ROC analyses are provided in the Table, indicating that a better discrimination between IIM and AVM patients was obtained when using texture features, with higher AUC and accuracy than mean T1 values (Figure). Conclusion. Texture analysis derived from MRI T1 maps without contrast agent injection was able to discriminate between IIM and AVM with higher accuracy, sensitivity and specificity than conventional T1 indices. Such analysis could provide a useful myocardial signature to help diagnose and manage cardiac alterations associated with IIM in patients presenting with myocarditis and primarily suspected of AVM. Table Area under curve (AUC) Accuracy Sensitivity Specificity Native T1 0.67 0.70 0.65 0.75 Post-contrast T1 0.49 0.60 0.25 0.95 Texture features score 0.85 0.82 0.90 0.75 ROC analyses for classification between IIM and AVM patients Abstract Figure

scholarly journals Imaging sequence for joint myocardial T1 mapping and fat/water separation

2018 ◽  
Vol 81 (1) ◽  
pp. 486-494 ◽  
Author(s):  
Maryam Nezafat ◽  
Shiro Nakamori ◽  
Tamer A. Basha ◽  
Ahmed S. Fahmy ◽  
Thomas Hauser ◽  
...  
Keyword(s):  
T1 Mapping ◽  
Water Separation ◽  
Imaging Sequence ◽  
Myocardial T1

scholarly journals Myocardial T1 Mapping: Techniques and Potential Applications

Radiographics ◽  
2014 ◽  
Vol 34 (2) ◽  
pp. 377-395 ◽  
Author(s):  
Jeremy R. Burt ◽  
Stefan L. Zimmerman ◽  
Ihab R. Kamel ◽  
Marc Halushka ◽  
David A. Bluemke
Keyword(s):  
T1 Mapping ◽  
Potential Applications ◽  
Myocardial T1 ◽  
Mapping Techniques

Comparison of myocardial T1 mapping during breath-holding and free-breathing

2021 ◽  
pp. 1-5
Author(s):  
Hideharu Oka ◽  
Kouichi Nakau ◽  
Sadahiro Nakagawa ◽  
Yuki Kobayashi ◽  
Rina Imanishi ◽  
...  
Keyword(s):  
Cross Sections ◽  
T1 Mapping ◽  
Free Breathing ◽  
Breath Holding ◽  
Basal Region ◽  
Analysis Method ◽  
Imaging Analysis ◽  
Myocardial T1 ◽  
The Mean ◽  
Almost All

Abstract Background: T1 mapping is a recently developed imaging analysis method that allows quantitative assessment of myocardial T1 values obtained using MRI. In children, MRI is performed under free-breathing. Thus, it is important to know the changes in T1 values between free-breathing and breath-holding. This study aimed to compare the myocardial T1 mapping during breath-holding and free-breathing. Methods: Thirteen patients and eight healthy volunteers underwent cardiac MRI, and T1 values obtained during breath-holding and free-breathing were examined and compared. Statistical differences were determined using the paired t-test. Results: The mean T1 values during breath-holding were 1211.1 ± 39.0 ms, 1209.7 ± 37.4 ms, and 1228.9 ± 52.5 ms in the basal, mid, and apical regions, respectively, while the mean T1 values during free-breathing were 1165.1 ± 69.0 ms, 1103.7 ± 55.8 ms, and 1112.0 ± 81.5 ms in the basal, mid, and apical regions, respectively. The T1 values were lower during free-breathing than during breath-holding in almost all segments (basal: p = 0.008, mid: p < 0.001, apical: p < 0.001). The mean T1 values in each cross section were 3.1, 7.8, and 7.7% lower during free-breathing than during breath-holding in the basal, mid, and apical regions, respectively. Conclusions: We found that myocardial T1 values during free-breathing were about 3–8% lower in all cross sections than those during breath-holding. In free-breathing, it may be difficult to assess myocardial T1 values, except in the basal region, because of underestimation; thus, the findings should be interpreted with caution, especially in children.

scholarly journals Comparison of myocardial T1 mapping techniques at 1.5T to detect interstitial fibrosis in patients with orthotopic cardiac transplant

2014 ◽  
Vol 16 (Suppl 1) ◽  
pp. P391
Author(s):  
Patrizia Pedrotti ◽  
Gabriella Masciocco ◽  
Giuseppina Quattrocchi ◽  
Angela Milazzo ◽  
Maria Frigerio ◽  
...  
Keyword(s):  
T1 Mapping ◽  
Interstitial Fibrosis ◽  
Cardiac Transplant ◽  
Myocardial T1 ◽  
Mapping Techniques

scholarly journals Motion correction for myocardial T1 mapping using image registration with synthetic image estimation

2011 ◽  
Vol 67 (6) ◽  
pp. 1644-1655 ◽  
Author(s):  
Hui Xue ◽  
Saurabh Shah ◽  
Andreas Greiser ◽  
Christoph Guetter ◽  
Arne Littmann ◽  
...  
Keyword(s):  
Image Registration ◽  
Motion Correction ◽  
T1 Mapping ◽  
Synthetic Image ◽  
Image Estimation ◽  
Myocardial T1
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