Amide proton transfer (APT) imaging of brain tumors at 7 T: The role of tissue water T1-Relaxation properties

2016 ◽  
Vol 77 (4) ◽  
pp. 1525-1532 ◽  
Author(s):  
Vitaliy Khlebnikov ◽  
Daniel Polders ◽  
Jeroen Hendrikse ◽  
Pierre A. Robe ◽  
Eduard H. Voormolen ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Proton Transfer ◽  
Amide Proton ◽  
Tissue Water ◽  
Relaxation Properties ◽  
Amide Proton Transfer ◽  
Apt Imaging ◽  
T1 Relaxation

scholarly journals Amide proton transfer weighted (APTw) imaging based radiomics allows for the differentiation of gliomas from metastases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Elisabeth Sartoretti ◽  
Thomas Sartoretti ◽  
Michael Wyss ◽  
Carolin Reischauer ◽  
Luuk van Smoorenburg ◽  
...  
Keyword(s):  
Machine Learning ◽  
Random Forest ◽  
Brain Tumors ◽  
Proton Transfer ◽  
Multilayer Perceptron ◽  
Random Forest Classifier ◽  
Amide Proton ◽  
Low Grade ◽  
Who Grade ◽  
Amide Proton Transfer

AbstractWe sought to evaluate the utility of radiomics for Amide Proton Transfer weighted (APTw) imaging by assessing its value in differentiating brain metastases from high- and low grade glial brain tumors. We retrospectively identified 48 treatment-naïve patients (10 WHO grade 2, 1 WHO grade 3, 10 WHO grade 4 primary glial brain tumors and 27 metastases) with either primary glial brain tumors or metastases who had undergone APTw MR imaging. After image analysis with radiomics feature extraction and post-processing, machine learning algorithms (multilayer perceptron machine learning algorithm; random forest classifier) with stratified tenfold cross validation were trained on features and were used to differentiate the brain neoplasms. The multilayer perceptron achieved an AUC of 0.836 (receiver operating characteristic curve) in differentiating primary glial brain tumors from metastases. The random forest classifier achieved an AUC of 0.868 in differentiating WHO grade 4 from WHO grade 2/3 primary glial brain tumors. For the differentiation of WHO grade 4 tumors from grade 2/3 tumors and metastases an average AUC of 0.797 was achieved. Our results indicate that the use of radiomics for APTw imaging is feasible and the differentiation of primary glial brain tumors from metastases is achievable with a high degree of accuracy.

scholarly journals Characterization of Lung Cancer by Amide Proton Transfer (APT) Imaging: An In-Vivo Study in an Orthotopic Mouse Model

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77019 ◽  
Author(s):  
Osamu Togao ◽  
Chase W. Kessinger ◽  
Gang Huang ◽  
Todd C. Soesbe ◽  
Koji Sagiyama ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Mouse Model ◽  
Proton Transfer ◽  
In Vivo Study ◽  
Amide Proton ◽  
Orthotopic Mouse Model ◽  
Amide Proton Transfer ◽  
Apt Imaging

scholarly journals Amide proton transfer (APT) contrast for imaging of brain tumors

2003 ◽  
Vol 50 (6) ◽  
pp. 1120-1126 ◽  
Author(s):  
Jinyuan Zhou ◽  
Bachchu Lal ◽  
David A. Wilson ◽  
John Laterra ◽  
Peter C.M. van Zijl
Keyword(s):  
Brain Tumors ◽  
Proton Transfer ◽  
Amide Proton ◽  
Amide Proton Transfer

Scan-rescan reproducibility of parallel transmission based amide proton transfer imaging of brain tumors

2015 ◽  
Vol 42 (5) ◽  
pp. 1346-1353 ◽  
Author(s):  
Osamu Togao ◽  
Akio Hiwatashi ◽  
Jochen Keupp ◽  
Koji Yamashita ◽  
Kazufumi Kikuchi ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Proton Transfer ◽  
Amide Proton ◽  
Parallel Transmission ◽  
Amide Proton Transfer ◽  
Amide Proton Transfer Imaging

Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors

2020 ◽  
Vol 129 ◽  
pp. 109047 ◽  
Author(s):  
Takeshi Kamitani ◽  
Koji Sagiyama ◽  
Osamu Togao ◽  
Yuzo Yamasaki ◽  
Tomoyuki Hida ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Amide Proton ◽  
Benign Tumors ◽  
Amide Proton Transfer ◽  
Parotid Tumors ◽  
Apt Imaging ◽  
Malignant And Benign Tumors

The role of amide proton transfer imaging in detecting active malignant glioma.

2011 ◽  
Vol 29 (15_suppl) ◽  
pp. 2024-2024 ◽  
Author(s):  
J. O. Blakeley ◽  
X. Ye ◽  
M. Lim ◽  
H. Zhu ◽  
L. Blair ◽  
...  
Keyword(s):  
Proton Transfer ◽  
Malignant Glioma ◽  
Amide Proton ◽  
Amide Proton Transfer ◽  
Amide Proton Transfer Imaging

scholarly journals Practical data acquisition method for human brain tumor amide proton transfer (APT) imaging

2008 ◽  
Vol 60 (4) ◽  
pp. 842-849 ◽  
Author(s):  
Jinyuan Zhou ◽  
Jaishri O. Blakeley ◽  
Jun Hua ◽  
Mina Kim ◽  
John Laterra ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Proton Transfer ◽  
Human Brain ◽  
Data Acquisition ◽  
Amide Proton ◽  
Human Brain Tumor ◽  
Amide Proton Transfer ◽  
Apt Imaging ◽  
Acquisition Method
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