scholarly journals Chemical shift separation with controlled aliasing for hyperpolarized13C metabolic imaging

2014 ◽  
Vol 74 (4) ◽  
pp. 978-989 ◽  
Author(s):  
Peter J. Shin ◽  
Peder E.Z. Larson ◽  
Martin Uecker ◽  
Galen D. Reed ◽  
Adam B. Kerr ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Metabolic Imaging

scholarly journals In vivo application of sub-second spiral chemical shift imaging (CSI) to hyperpolarized 13C metabolic imaging: Comparison with phase-encoded CSI

2010 ◽  
Vol 204 (2) ◽  
pp. 340-345 ◽  
Author(s):  
Dirk Mayer ◽  
Yi-Fen Yen ◽  
Yakir S. Levin ◽  
James Tropp ◽  
Adolf Pfefferbaum ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Chemical Shift Imaging ◽  
Metabolic Imaging ◽  
Hyperpolarized 13C

scholarly journals Least-squares chemical shift separation for13C metabolic imaging

2007 ◽  
Vol 26 (4) ◽  
pp. 1145-1152 ◽  
Author(s):  
Scott B. Reeder ◽  
Jean H. Brittain ◽  
Thomas M. Grist ◽  
Yi-Fen Yen
Keyword(s):  
Chemical Shift ◽  
Least Squares ◽  
Metabolic Imaging

scholarly journals Dynamic metabolic imaging of hyperpolarized [2-13 C]pyruvate using spiral chemical shift imaging with alternating spectral band excitation

2013 ◽  
Vol 71 (6) ◽  
pp. 2051-2058 ◽  
Author(s):  
Sonal Josan ◽  
Ralph Hurd ◽  
Jae Mo Park ◽  
Yi-Fen Yen ◽  
Ron Watkins ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Spectral Band ◽  
Chemical Shift Imaging ◽  
Metabolic Imaging

scholarly journals Application of subsecond spiral chemical shift imaging to real-time multislice metabolic imaging of the rat in vivo after injection of hyperpolarized 13 C1 -pyruvate

2009 ◽  
Vol 62 (3) ◽  
pp. 557-564 ◽  
Author(s):  
Dirk Mayer ◽  
Yi-Fen Yen ◽  
James Tropp ◽  
Adolf Pfefferbaum ◽  
Ralph E. Hurd ◽  
...  
Keyword(s):  
Chemical Shift ◽  
Real Time ◽  
Chemical Shift Imaging ◽  
Metabolic Imaging

Myocardial Metabolic Imaging in the Clinical Setting

2009 ◽  
Vol 5 (1) ◽  
pp. 15
Author(s):  
Nagara Tamaki ◽  
Yuji Kuge ◽  
Keiichiro Yoshinaga ◽  
◽  
◽  
...  
Keyword(s):  
Heart Failure ◽  
Fatty Acid ◽  
Clinical Setting ◽  
Photon Emission ◽  
Tca Cycle ◽  
Emission Tomography ◽  
Metabolic Imaging ◽  
Myocardial Uptake ◽  
Glucose Utilisation ◽  
Myocardial Metabolic Imaging

Glucose and free fatty acids are a major energy source in the myocardium. Metabolic imaging with single photon emission tomography (SPECT) and positron emission tomography (PET) have been widely used for the evaluation of the pathophysiology of coronary artery disease (CAD) and heart failure. 18F fluorodeoxyglucose (FDG) is a glucose analogue that is used to measure myocardial glucose utilisation. The myocardial uptake of a modified branched fatty acid, 15-(p-[iodine-123] iodophenyl)-3-(R,S) methylpentadecanoic acid (BMIPP), reflects the activation of fatty-acid metabolism by co-enzyme A (CoA) and indirectly reflects cellular adenosine triphosphate (ATP) production. The turnover rate of the tricarboxylic acid (TCA) cycle reflects the rate of overall myocardial oxidative metabolism. 11C acetate is readily metabolised to CO2 almost exclusively through the TCA cycle. These three major agents have been most commonly used for probing myocardial energy metabolism in vivo. Such metabolic imaging has been used for assessing myocardial viability on the basis of persistent glucose utilisation in ischaemic but viable myocardium. BMIPP and FDG have been identified for locating a recent history of myocardial ischaemia. Furthermore, metabolic imaging is promising for the assessment of the pathophysiology of heart failure and the treatment effect of various drugs, as well as mechanical treatments. In this article we will provide an overview of the application of myocardial metabolic imaging in a clinical setting.

Macrocycles of Higher Ortho-Phenylenes: Assembly and Folding

2019 ◽  
Author(s):  
Zacharias Kinney ◽  
Viraj Kirinda ◽  
Scott Hartley
Keyword(s):  
Chemical Shift ◽  
Higher Order ◽  
Order Structure ◽  
Complex Geometries ◽  
Spatial Relationships ◽  
Predominant Species ◽  
Bite Angle ◽  
Direct Assembly

<p>Higher-order structure in abiotic foldamer systems represents an important but largely unrealized goal. As one approach to this challenge, covalent assembly can be used to assemble macrocycles with foldamer subunits in well-defined spatial relationships. Such systems have previously been shown to exhibit self-sorting, new folding motifs, and dynamic stereoisomerism, yet there remain important questions about the interplay between folding and macrocyclization and the effect of structural confinement on folding behavior. Here, we explore the dynamic covalent assembly of extended <i>ortho</i>-phenylenes (hexamer and decamer) with rod-shaped linkers. Characteristic <sup>1</sup>H chemical shift differences between cyclic and acyclic systems can be compared with computational conformer libraries to determine the folding states of the macrocycles. We show that the bite angle provides a measure of the fit of an <i>o</i>-phenylene conformer within a shape-persistent macrocycle, affecting both assembly and ultimate folding behavior. For the <i>o</i>-phenylene hexamer, the bite angle and conformer stability work synergistically to direct assembly toward triangular [3+3] macrocycles of well-folded oligomers. For the decamer, the energetic accessibility of conformers with small bite angles allows [2+2] macrocycles to be formed as the predominant species. In these systems, the <i>o</i>-phenylenes are forced into unusual folding states, preferentially adopting a backbone geometry with distinct helical blocks of opposite handedness. The results show that simple geometric restrictions can be used to direct foldamers toward increasingly complex geometries.</p>

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