scholarly journals Simultaneous acquisition of cerebral blood volume-, blood flow-, and blood oxygenation-weighted MRI signals at ultra-high magnetic field

2014 ◽  
Vol 74 (2) ◽  
pp. 513-517 ◽  
Author(s):  
Steffen N. Krieger ◽  
Laurentius Huber ◽  
Benedikt A. Poser ◽  
Robert Turner ◽  
Gary F. Egan
Keyword(s):  
Magnetic Field ◽  
Blood Flow ◽  
Blood Volume ◽  
High Magnetic Field ◽  
Cerebral Blood Volume ◽  
Blood Oxygenation ◽  
Simultaneous Acquisition ◽  
Volume Blood ◽  
Volume Blood Flow

scholarly journals The Effects of Changes in PaCO2Cerebral Blood Volume, Blood Flow, and Vascular Mean Transit Time

Stroke ◽  
1974 ◽  
Vol 5 (5) ◽  
pp. 630-639 ◽  
Author(s):  
ROBERT L. GRUBB ◽  
MARCUS E. RAICHLE ◽  
JOHN O. EICHLING ◽  
MICHEL M. TER-POGOSSIAN
Keyword(s):  
Blood Flow ◽  
Blood Volume ◽  
Transit Time ◽  
Mean Transit Time ◽  
Volume Blood ◽  
Volume Blood Flow

scholarly journals Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models

2016 ◽  
Vol 37 (6) ◽  
pp. 2270-2282 ◽  
Author(s):  
Ararat Chakhoyan ◽  
Aurélien Corroyer-Dulmont ◽  
Marine M Leblond ◽  
Aurélie Gérault ◽  
Jérôme Toutain ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Blood Oxygenation Level Dependent ◽  
Blood Oxygenation ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Blood Oxygenation Level ◽  
Oxygenation Level ◽  
Volume Blood

The alleviation of hypoxia in glioblastoma with carbogen to improve treatment has met with limited success. Our hypothesis is that the eventual benefits of carbogen depend on the capacity for vasodilation. We examined, with MRI, changes in fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent signals in response to carbogen. The analyses were performed in two xenograft models of glioma (U87 and U251) recognized to have different vascular patterns. Carbogen increased fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent signals in contralateral tissues. In the tumor core and peritumoral regions, changes were dependent on the capacity to vasodilate rather than on resting fractional cerebral blood volume. In the highly vascularised U87 tumor, carbogen induced a greater increase in fractional cerebral blood volume and blood oxygen saturation in comparison to the less vascularized U251 tumor. The blood oxygenation level dependent signal revealed a delayed response in U251 tumors relative to the contralateral tissue. Additionally, we highlight the considerable heterogeneity of fractional cerebral blood volume, blood oxygen saturation, and blood oxygenation level dependent within U251 tumor in which multiple compartments co-exist (tumor core, rim and peritumoral regions). Finally, our study underlines the complexity of the flow/metabolism interactions in different models of glioblastoma. These irregularities should be taken into account in order to palliate intratumoral hypoxia in clinical trials.

scholarly journals Striatal and Cortical BOLD, Blood Flow, Blood Volume, Oxygen Consumption, and Glucose Consumption Changes in Noxious Forepaw Electrical Stimulation

2010 ◽  
Vol 31 (3) ◽  
pp. 832-841 ◽  
Author(s):  
Yen-Yu I Shih ◽  
Hsiao-Ying Wey ◽  
Bryan H De La Garza ◽  
Timothy Q Duong
Keyword(s):  
Blood Flow ◽  
Oxygen Consumption ◽  
Metabolic Rate ◽  
Blood Volume ◽  
Functional Imaging ◽  
Cerebral Blood Volume ◽  
Glucose Consumption ◽  
Blood Oxygenation ◽  
Cerebral Metabolic Rate ◽  
Positron Emission

Recent reports showed noxious forepaw stimulation in rats evoked an unexpected sustained decrease in cerebral blood volume (CBV) in the bilateral striatum, whereas increases in spike activity and Fos-immunoreactive cells were observed. This study aimed to further evaluate the hemodynamic and metabolic needs in this model and the sources of negative functional magnetic resonance imaging (fMRI) signals by measuring blood oxygenation-level-dependent (BOLD), cerebral-blood-flow (CBF), CBV, and oxygen-consumption (i.e., cerebral metabolic rate of oxygen (CMRO2)) changes using an 11.7-T MRI scanner, and glucose-consumption (i.e., cerebral metabolic rate of glucose (CMRglc)) changes using micro-positron emission tomography. In the contralateral somatosensory cortex, BOLD, CBF, CBV, CMRO2 ( n=7, P<0.05), and CMRglc ( n=5, P<0.05) increased. In contrast, in the bilateral striatum, BOLD, CBF, and CBV decreased ( P<0.05), CMRO2 decreased slightly, although not significantly from baseline, and CMRglc was not statistically significant from baseline ( P>0.05). These multimodal functional imaging findings corroborate the unexpected negative hemodynamic changes in the striatum during noxious forepaw stimulation, and support the hypothesis that striatal hemodynamic response is dominated by neurotransmitter-mediated vasoconstriction, overriding the stimulus-evoked fMRI signal increases commonly accompany elevated neuronal activity. Multimodal functional imaging approach offers a means to probe the unique attributes of the striatum, providing novel insights into the neurovascular coupling in the striatum. These findings may have strong implications in fMRI studies of pain.

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