scholarly journals Influence of spatial resolution on the accuracy of quantitative myocardial perfusion in first pass stress perfusion CMR

2014 ◽  
Vol 73 (4) ◽  
pp. 1623-1631 ◽  
Author(s):  
Niloufar Zarinabad ◽  
Amedeo Chiribiri ◽  
Gilion L. T. F. Hautvast ◽  
Marcel Breeuwer ◽  
Eike Nagel
Keyword(s):  
Myocardial Perfusion ◽  
Spatial Resolution ◽  
Stress Perfusion ◽  
First Pass ◽  
Quantitative Myocardial Perfusion ◽  
Perfusion Cmr

scholarly journals First pass vasodilator-stress myocardial perfusion CMR in mice on a whole-body 3Tesla scanner: validation against microspheres

2012 ◽  
Vol 14 (S1) ◽  
Author(s):  
Roy Jogiya ◽  
Marcus R Makowski ◽  
Alkystis Phinikaridou ◽  
Christian Jansen ◽  
Niloufar Zarinabad ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Vasodilator Stress ◽  
Whole Body ◽  
Stress Myocardial Perfusion ◽  
First Pass ◽  
Perfusion Cmr

scholarly journals The relationship between spatial resolution levels and quantitative myocardial perfusion

2013 ◽  
Vol 15 (S1) ◽  
Author(s):  
Niloufar Zarinabad ◽  
Gilion Hautvast ◽  
Marcel Breeuwer ◽  
Eike Nagel ◽  
Amedeo Chiribiri
Keyword(s):  
Myocardial Perfusion ◽  
Spatial Resolution ◽  
Quantitative Myocardial Perfusion ◽  
The Relationship

scholarly journals Myocardial Perfusion Imaging After Severe COVID-19 Infection Demonstrates Regional Ischemia Rather Than Global Blood Flow Reduction

2021 ◽  
Vol 8 ◽  
Author(s):  
George D. Thornton ◽  
Abhishek Shetye ◽  
Dan S. Knight ◽  
Kris Knott ◽  
Jessica Artico ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Perfusion ◽  
Left Ventricular ◽  
Regional Perfusion ◽  
Left Ventricular Ejection ◽  
Stress Perfusion ◽  
Post Discharge ◽  
High Prevalence ◽  
Perfusion Defects ◽  
Perfusion Cmr

Background: Acute myocardial damage is common in severe COVID-19. Post-mortem studies have implicated microvascular thrombosis, with cardiovascular magnetic resonance (CMR) demonstrating a high prevalence of myocardial infarction and myocarditis-like scar. The microcirculatory sequelae are incompletely characterized. Perfusion CMR can quantify the stress myocardial blood flow (MBF) and identify its association with infarction and myocarditis.Objectives: To determine the impact of the severe hospitalized COVID-19 on global and regional myocardial perfusion in recovered patients.Methods: A case-control study of previously hospitalized, troponin-positive COVID-19 patients was undertaken. The results were compared with a propensity-matched, pre-COVID chest pain cohort (referred for clinical CMR; angiography subsequently demonstrating unobstructed coronary arteries) and 27 healthy volunteers (HV). The analysis used visual assessment for the regional perfusion defects and AI-based segmentation to derive the global and regional stress and rest MBF.Results: Ninety recovered post-COVID patients {median age 64 [interquartile range (IQR) 54–71] years, 83% male, 44% requiring the intensive care unit (ICU)} underwent adenosine-stress perfusion CMR at a median of 61 (IQR 29–146) days post-discharge. The mean left ventricular ejection fraction (LVEF) was 67 ± 10%; 10 (11%) with impaired LVEF. Fifty patients (56%) had late gadolinium enhancement (LGE); 15 (17%) had infarct-pattern, 31 (34%) had non-ischemic, and 4 (4.4%) had mixed pattern LGE. Thirty-two patients (36%) had adenosine-induced regional perfusion defects, 26 out of 32 with at least one segment without prior infarction. The global stress MBF in post-COVID patients was similar to the age-, sex- and co-morbidities of the matched controls (2.53 ± 0.77 vs. 2.52 ± 0.79 ml/g/min, p = 0.10), though lower than HV (3.00 ± 0.76 ml/g/min, p< 0.01).Conclusions: After severe hospitalized COVID-19 infection, patients who attended clinical ischemia testing had little evidence of significant microvascular disease at 2 months post-discharge. The high prevalence of regional inducible ischemia and/or infarction (nearly 40%) may suggest that occult coronary disease is an important putative mechanism for troponin elevation in this cohort. This should be considered hypothesis-generating for future studies which combine ischemia and anatomical assessment.

Quantitative Myocardial Perfusion CMR

2018 ◽  
Vol 11 (5) ◽  
pp. 784-786 ◽  
Author(s):  
Christopher M. Kramer ◽  
Y. Chandrashekhar
Keyword(s):  
Myocardial Perfusion ◽  
Quantitative Myocardial Perfusion ◽  
Perfusion Cmr

scholarly journals Reproducibility of First Pass Perfusion CMR at rest and during hyperaemia for estimation of myocardial perfusion

2010 ◽  
Vol 12 (S1) ◽  
Author(s):  
Abdulghani M Larghat ◽  
Aleksandra Radjenovic ◽  
Neil Maredia ◽  
John Biglands ◽  
John Greenwood ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Pass Perfusion ◽  
First Pass ◽  
First Pass Perfusion ◽  
Perfusion Cmr

scholarly journals Combined simultaneous multislice bSSFP and compressed sensing for first‐pass myocardial perfusion at 1.5 T with high spatial resolution and coverage

2020 ◽  
Vol 84 (6) ◽  
pp. 3103-3116 ◽  
Author(s):  
Sarah McElroy ◽  
Giulio Ferrazzi ◽  
Muhummad Sohaib Nazir ◽  
Karl P. Kunze ◽  
Radhouene Neji ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Compressed Sensing ◽  
Spatial Resolution ◽  
High Spatial Resolution ◽  
First Pass ◽  
Simultaneous Multislice

scholarly journals Quantitative myocardial perfusion analysis with a dual-bolus contrast-enhanced first-pass MRI technique in humans

2006 ◽  
Vol 23 (3) ◽  
pp. 315-322 ◽  
Author(s):  
Li-Yueh Hsu ◽  
Kenneth L. Rhoads ◽  
Jessica E. Holly ◽  
Peter Kellman ◽  
Anthony H. Aletras ◽  
...  
Keyword(s):  
Myocardial Perfusion ◽  
Contrast Enhanced ◽  
First Pass ◽  
Quantitative Myocardial Perfusion ◽  
Dual Bolus

scholarly journals Use of quantitative myocardial perfusion mapping by CMR for characterisation of ischaemia in patients post coronary artery bypass graft surgery

2021 ◽  
Vol 22 (Supplement_1) ◽  
Author(s):  
A Seraphim ◽  
K Knott ◽  
AM Beirne ◽  
J Augusto ◽  
K Menacho ◽  
...  
Keyword(s):  
Blood Flow ◽  
Myocardial Perfusion ◽  
Myocardial Blood Flow ◽  
Perfusion Defect ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Artery Bypass Graft ◽  
Quantitative Myocardial Perfusion ◽  
Perfusion Defects ◽  
Perfusion Cmr

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): British Heart Foundation Background Quantitative myocardial perfusion mapping using Cardiac Magnetic Resonance (CMR) imaging is used for evaluation of ischaemia in the context of native vessel coronary disease, but its diagnostic performance in patients with grafts is not well established. Perfusion defects are often detected in these patients, but whether these are a consequence of a technical limitation (delayed contrast arrival from graft conduits) or a true reflection of reduced myocardial blood flow is unclear. Methods 39 patients undergoing stress perfusion CMR with previous coronary artery bypass graft (CABG) surgery, unobstructed left internal mammary artery (LIMA) grafts to the left anterior descending (LAD) artery on coronary angiography and no CMR evidence of prior LAD infarction were included. Myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) were evaluated with quantitative perfusion mapping and the factors determining MBF in the LIMA-LAD territory (AHA segments 1,2,7,8,13,14), including the impact of delayed contrast arrival through the LIMA graft were evaluated. Results In 28 out of 39 cases a myocardial perfusion defect was reported on visual assessment in LIMA-LAD myocardial territory, despite the presence of unobstructed LIMA graft and no LAD infarction. Chronic total occlusion (CTO) of the native LAD was an independent predictor of stress MBF (B=-0.36, p =0.027) and the strongest predictor of MPR (B=-0.55, p 0.005) within the LIMA-LAD myocardial territory after adjusting for age, left ventricular (LV) ejection fraction, and presence of diabetes. CTO of the native LAD was associated with a reduction in stress MBF in the basal myocardial segments (-0.57ml/g/min, p = 0.002) but had no effect on the MBF of apical segments (-0.31ml/g/min, p = 0.084). Increasing the maximum value for allowable arterial delay (TA) of contrast in the quantitative mapping algorithm resulted in a small increase in myocardial blood flow in the LIMA-LAD territory both at stress (0.07 ± 0.08ml/g/min, p < 0.001) and rest (0.06 ± 0.05ml/g/min, p < 0.001). Conclusions Perfusion defects detected in LIMA-LAD subtended territories are common despite graft patency. These defects are likely to represent genuine reduction in MBF, resulting from native LAD coronary occlusion. Prolonged contrast transit time associated with LIMA grafts results in small underestimation of MBF as measured by quantitative CMR perfusion mapping, but does not account for the degree of MBF reduction seen in these patients. Figure 1. Study patient with unobstructed LIMA to LAD graft and evidence of inducible perfusion defect in LIMA-LAD territories. (A): First pass perfusion CMR imaging. (B): Perfusion mapping showing reduced stress MBF in mid antero-septum (0.85ml/g/min) compared to the apical septum (1.65ml/g/min). (C): Late gadolinium enhancement showing no evidence of previous infarction. (D,E): Coronary angiography demonstrating unobstructed LIMA graft (D) and anastomosis site (E). Abstract Figure 1.

Contemporary Issues in Quantitative Myocardial Perfusion CMR Imaging

2019 ◽  
Vol 12 (3) ◽  
Author(s):  
Austin A. Robinson ◽  
Michael Salerno ◽  
Christopher M. Kramer
Keyword(s):  
Myocardial Perfusion ◽  
Quantitative Myocardial Perfusion ◽  
Perfusion Cmr ◽  
Cmr Imaging
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