In vivo imaging of islet transplantation using PLGA nanoparticles containing iron oxide and indocyanine green

2013 ◽  
Vol 71 (3) ◽  
pp. 1054-1063 ◽  
Author(s):  
Jung Hwan Hwang ◽  
Young-Woock Noh ◽  
Jung-Hyun Choi ◽  
Jung-Ran Noh ◽  
Yong-Hoon Kim ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Indocyanine Green ◽  
Islet Transplantation ◽  
In Vivo Imaging ◽  
Plga Nanoparticles

scholarly journals Dye-doped biodegradable nanoparticle SiO2 coating on zinc- and iron-oxide nanoparticles to improve biocompatibility and for in vivo imaging studies

Nanoscale ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 6164-6175 ◽  
Author(s):  
Elena Navarro-Palomares ◽  
Paula González-Saiz ◽  
Carlos Renero-Lecuna ◽  
Rosa Martín-Rodríguez ◽  
Fernando Aguado ◽  
...  
Keyword(s):  
Iron Oxide ◽  
In Vivo Imaging ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Imaging Studies ◽  
Sio2 Coating ◽  
Shell Nanoparticles ◽  
Nano Medicine ◽  
Core Shell Nanoparticles

Core–shell nanoparticles provide two fold functionality in nano medicine: reduction of nanotoxicity and improving as a tool for imaging and therapy.

scholarly journals Reply to 'In vivo imaging of islet transplantation'

2007 ◽  
Vol 13 (7) ◽  
pp. 773-773 ◽  
Author(s):  
Anna Moore ◽  
Zdravka Medarova ◽  
Natalia V Evgenov ◽  
Guangping Dai ◽  
Susan Bonner-Weir
Keyword(s):  
Islet Transplantation ◽  
In Vivo Imaging

scholarly journals Indocyanine Green-Nexturastat A-PLGA Nanoparticles Combine Photothermal and Epigenetic Therapy for Melanoma

Nanomaterials ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 161 ◽  
Author(s):  
Debbie K. Ledezma ◽  
Preethi B. Balakrishnan ◽  
Juliana Cano-Mejia ◽  
Elizabeth E. Sweeney ◽  
Melissa Hadley ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Specific Activity ◽  
Melanoma Cells ◽  
Plga Nanoparticles ◽  
Epigenetic Therapy ◽  
Photothermal Heating ◽  
Epigenetic Drug

In this study, we describe poly (lactic-co-glycolic) acid (PLGA)-based nanoparticles that combine photothermal therapy (PTT) with epigenetic therapy for melanoma. Specifically, we co-encapsulated indocyanine green (ICG), a PTT agent, and Nexturastat A (NextA), an epigenetic drug within PLGA nanoparticles (ICG-NextA-PLGA; INAPs). We hypothesized that combining PTT with epigenetic therapy elicits favorable cytotoxic and immunomodulatory responses that result in improved survival in melanoma-bearing mice. We utilized a nanoemulsion synthesis scheme to co-encapsulate ICG and NextA within stable and monodispersed INAPs. The INAPs exhibited concentration-dependent and near-infrared (NIR) laser power-dependent photothermal heating characteristics, and functioned as effective single-use agents for PTT of melanoma cells in vitro. The INAPs functioned as effective epigenetic therapy agents by inhibiting the expression of pan-histone deacetylase (HDAC) and HDAC6-specific activity in melanoma cells in vitro. When used for both PTT and epigenetic therapy in vitro, the INAPs increased the expression of co-stimulatory molecules and major histocompatibility complex (MHC) Class I in melanoma cells relative to controls. These advantages persisted in vivo in a syngeneic murine model of melanoma, where the combination therapy slowed tumor progression and improved median survival. These findings demonstrate the potential of INAPs as agents of PTT and epigenetic therapy for melanoma.

scholarly journals Compact zwitterion-coated iron oxide nanoparticles for in vitro and in vivo imaging

2012 ◽  
Vol 5 (1) ◽  
pp. 108-114 ◽  
Author(s):  
He Wei ◽  
Oliver T. Bruns ◽  
Ou Chen ◽  
Moungi G. Bawendi
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
In Vivo Imaging ◽  
Oxide Nanoparticles

A preliminary study on the application of paramagnetic composite nanoparticles in the navigation of hepatectomy

2021 ◽  
Vol 11 (11) ◽  
pp. 1833-1840
Author(s):  
Bin Shen ◽  
Shugang Sun
Keyword(s):  
Iron Oxide ◽  
Liver Cancer ◽  
Indocyanine Green ◽  
Hepatic Resection ◽  
Primary Liver Cancer ◽  
Superparamagnetic Iron Oxide ◽  
Carboxymethyl Chitosan ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle

As the preferred treatment strategy for primary liver cancer, hepatic resection surgery can effectively improve the survival of liver cancer patients without relying on other treatments. However, traditional hepatic resection surgery cannot achieve precise localization of the cancer foci boundary. Therefore, improving hepatectomy targeting and reducing the metabolic rate of contrast agents in vivo has become an urgent challenge. This study constructed a novel indocyanine green nanocomposite fluorescent contrast agent, known as indocyanine green-carboxymethyl chitosan/superparamagnetic iron oxide nanoparticle (ICG-CMCS/SIO NP), based on a superparamagnetic iron oxide. The carboxymethyl chitosan and indocyanine green (ICG)’s graft copolymer served as a nanomaterial shell. This shell enhanced ICG targeting’s control ability and stability while effectively retaining its core magnetic properties. Thus, ICG-CMCS/SIO NPs should provide a novel idea for the study of clinical hepatocellular carcinoma resection surgery navigation.

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