scholarly journals Integrated Bloch-Siegert B1 mapping and multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart

2011 ◽  
Vol 67 (1) ◽  
pp. 62-71 ◽  
Author(s):  
Angus Z. Lau ◽  
Albert P. Chen ◽  
Charles H. Cunningham
Keyword(s):  
Hyperpolarized 13C ◽  
B1 Mapping ◽  
Multislice Imaging

scholarly journals Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart

2010 ◽  
Vol 64 (5) ◽  
pp. 1323-1331 ◽  
Author(s):  
Angus Z. Lau ◽  
Albert P. Chen ◽  
Nilesh R. Ghugre ◽  
Venkat Ramanan ◽  
Wilfred W. Lam ◽  
...  
Keyword(s):  
Hyperpolarized 13C ◽  
Multislice Imaging

Multislice imaging of gastrointestinal stromal tumors

2018 ◽  
pp. 3-14
Keyword(s):  
Computed Tomography ◽  
Key Words ◽  
Gold Standard ◽  
Gastrointestinal Stromal Tumors ◽  
Mesenchymal Tumors ◽  
Stromal Tumors ◽  
Preferential Localization ◽  
Multislice Imaging ◽  
Computed Tomography Diagnosis

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the digestive tract (1%). These tumors express the CD 117 in 95% of cases. The stomach is the preferential localization (70%). Diagnosis is difficult and sometimes late. Progress of imaging has greatly improved the management and the prognosis. Computed tomography (CT) is the gold standard for diagnosis, staging, and treatment follow-up. The increasing recognition of GIST’s histopathology and the prolonged survival revealed some suggestive imaging aspects. Key words: gastro-intestinal stromal tumors; computed tomography; diagnosis

scholarly journals Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mor Mishkovsky ◽  
Olga Gusyatiner ◽  
Bernard Lanz ◽  
Cristina Cudalbu ◽  
Irene Vassallo ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Tumor Recurrence ◽  
Aerobic Glycolysis ◽  
Imaging Techniques ◽  
Tumor Type ◽  
Hyperpolarized 13C ◽  
Metabolic Heterogeneity ◽  
Metabolic Information ◽  
Opposite Response

AbstractGlioblastoma (GBM) is the most aggressive brain tumor type in adults. GBM is heterogeneous, with a compact core lesion surrounded by an invasive tumor front. This front is highly relevant for tumor recurrence but is generally non-detectable using standard imaging techniques. Recent studies demonstrated distinct metabolic profiles of the invasive phenotype in GBM. Magnetic resonance (MR) of hyperpolarized 13C-labeled probes is a rapidly advancing field that provides real-time metabolic information. Here, we applied hyperpolarized 13C-glucose MR to mouse GBM models. Compared to controls, the amount of lactate produced from hyperpolarized glucose was higher in the compact GBM model, consistent with the accepted “Warburg effect”. However, the opposite response was observed in models reflecting the invasive zone, with less lactate produced than in controls, implying a reduction in aerobic glycolysis. These striking differences could be used to map the metabolic heterogeneity in GBM and to visualize the infiltrative front of GBM.

scholarly journals Characterization of Distinctive In Vivo Metabolism between Enhancing and Non-Enhancing Gliomas Using Hyperpolarized Carbon-13 MRI

Metabolites ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 504
Author(s):  
Seunggwi Park ◽  
Hashizume Rintaro ◽  
Seul Kee Kim ◽  
Ilwoo Park
Keyword(s):  
Metabolic Imaging ◽  
Metabolic Profiles ◽  
Rodent Models ◽  
In Vivo Metabolism ◽  
Hyperpolarized 13C ◽  
Noninvasive Assessment ◽  
Diffuse Midline Glioma ◽  
Mr Spectroscopic Imaging

The development of hyperpolarized carbon-13 (13C) metabolic MRI has enabled the sensitive and noninvasive assessment of real-time in vivo metabolism in tumors. Although several studies have explored the feasibility of using hyperpolarized 13C metabolic imaging for neuro-oncology applications, most of these studies utilized high-grade enhancing tumors, and little is known about hyperpolarized 13C metabolic features of a non-enhancing tumor. In this study, 13C MR spectroscopic imaging with hyperpolarized [1-13C]pyruvate was applied for the differential characterization of metabolic profiles between enhancing and non-enhancing gliomas using rodent models of glioblastoma and a diffuse midline glioma. Distinct metabolic profiles were found between the enhancing and non-enhancing tumors, as well as their contralateral normal-appearing brain tissues. The preliminary results from this study suggest that the characterization of metabolic patterns from hyperpolarized 13C imaging between non-enhancing and enhancing tumors may be beneficial not only for understanding distinct metabolic features between the two lesions, but also for providing a basis for understanding 13C metabolic processes in ongoing clinical trials with neuro-oncology patients using this technology.

Fast oxygen-enhanced multislice imaging of the lung using parallel acquisition techniques

2005 ◽  
Vol 53 (6) ◽  
pp. 1317-1325 ◽  
Author(s):  
Olaf Dietrich ◽  
Christoph Losert ◽  
Ulrike Attenberger ◽  
Ulrike Fasol ◽  
Michael Peller ◽  
...  
Keyword(s):  
Parallel Acquisition ◽  
Multislice Imaging

scholarly journals In Vivo Assessment of Metabolic Abnormality in Alport Syndrome Using Hyperpolarized [1-13C] Pyruvate MR Spectroscopic Imaging

Metabolites ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 222
Author(s):  
Nguyen-Trong Nguyen ◽  
Eun-Hui Bae ◽  
Luu-Ngoc Do ◽  
Tien-Anh Nguyen ◽  
Ilwoo Park ◽  
...  
Keyword(s):  
Disease Progression ◽  
Alport Syndrome ◽  
Genetic Disorder ◽  
Lactate Production ◽  
Clinical Importance ◽  
Metabolic Imaging ◽  
Renal Metabolism ◽  
Hyperpolarized 13C ◽  
And Control

Alport Syndrome (AS) is a genetic disorder characterized by impaired kidney function. The development of a noninvasive tool for early diagnosis and monitoring of renal function during disease progression is of clinical importance. Hyperpolarized 13C MRI is an emerging technique that enables non-invasive, real-time measurement of in vivo metabolism. This study aimed to investigate the feasibility of using this technique for assessing changes in renal metabolism in the mouse model of AS. Mice with AS demonstrated a significant reduction in the level of lactate from 4- to 7-week-old, while the levels of lactate were unchanged in the control mice over time. This reduction in lactate production in the AS group accompanied a significant increase of PEPCK expression levels, indicating that the disease progression in AS triggered the gluconeogenic pathway and might have resulted in a decreased lactate pool size and a subsequent reduction in pyruvate-to-lactate conversion. Additional metabolic imaging parameters, including the level of lactate and pyruvate, were found to be different between the AS and control groups. These preliminary results suggest that hyperpolarized 13C MRI might provide a potential noninvasive tool for the characterization of disease progression in AS.

scholarly journals Pyruvate to Lactate Metabolic Changes during Neurodevelopment Measured Dynamically Using Hyperpolarized 13C Imaging in Juvenile Murine Brain

2015 ◽  
Vol 38 (1) ◽  
pp. 34-40 ◽  
Author(s):  
Yiran Chen ◽  
Hosung Kim ◽  
Robert Bok ◽  
Subramaniam Sukumar ◽  
Xin Mu ◽  
...  
Keyword(s):  
Body Weight ◽  
Magnetic Resonance ◽  
Mouse Brain ◽  
Brain Volume ◽  
Metabolic Changes ◽  
Brain Maturation ◽  
Multiple Time ◽  
Total Brain Volume ◽  
Hyperpolarized 13C ◽  
Total Brain

Hyperpolarized 13C magnetic resonance imaging has recently been used to dynamically image metabolism in vivo. This technique provides the capability to investigate metabolic changes in mouse brain development over multiple time points. In this study, we used 13C magnetic resonance spectroscopic imaging and hyperpolarized 13C-1-labeled pyruvate to analyze its conversion into lactate. We also applied T2-weighted anatomical imaging to examine brain volume changes starting from postnatal day 18 (P18). We combined these results with body weight measurements for a comprehensive interpretation of mouse brain maturation. Both the produced lactate level and pyruvate to lactate conversion rate decreased with increasing age in a linear manner. Total brain volume remained the same after P18, even though body weight continued to grow exponentially. Our results have shown that the rate of metabolism of 13C-1 pyruvate to lactate in brain is high in the young mouse and decreases with age. The brain at P18 is still relatively immature and continues to develop even as the total brain volume remains the same.

scholarly journals A Comparison between Radiolabeled Fluorodeoxyglucose Uptake and Hyperpolarized 13C-Labeled Pyruvate Utilization as Methods for Detecting Tumor Response to Treatment

Neoplasia ◽  
2009 ◽  
Vol 11 (6) ◽  
pp. 574-IN11 ◽  
Author(s):  
Timothy H. Witney ◽  
Mikko I. Kettunen ◽  
Samuel E. Day ◽  
De-en Hu ◽  
Andre A. Neves ◽  
...  
Keyword(s):  
Tumor Response ◽  
Response To Treatment ◽  
Hyperpolarized 13C
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