scholarly journals Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies

2010 ◽  
Vol 65 (3) ◽  
pp. 610-619 ◽  
Author(s):  
Peder E. Z. Larson ◽  
Simon Hu ◽  
Michael Lustig ◽  
Adam B. Kerr ◽  
Sarah J. Nelson ◽  
...  
Keyword(s):  
Compressed Sensing ◽  
Spectroscopic Imaging ◽  
Hyperpolarized 13C ◽  
Multiband Excitation ◽  
Fast Dynamic ◽  
Mr Spectroscopic Imaging

scholarly journals In vivo hyperpolarized 13C MR spectroscopic imaging with 1H decoupling

2009 ◽  
Vol 197 (1) ◽  
pp. 100-106 ◽  
Author(s):  
Albert P. Chen ◽  
James Tropp ◽  
Ralph E. Hurd ◽  
Mark Van Criekinge ◽  
Lucas G. Carvajal ◽  
...  
Keyword(s):  
Spectroscopic Imaging ◽  
Hyperpolarized 13C ◽  
Mr Spectroscopic Imaging

scholarly journals Mapping of fatty acid composition with free‐breathing MR spectroscopic imaging and compressed sensing

2020 ◽  
Author(s):  
James A. Rioux ◽  
Miriam Hewlett ◽  
Christa Davis ◽  
Chris V. Bowen ◽  
Kimberly Brewer ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Compressed Sensing ◽  
Acid Composition ◽  
Spectroscopic Imaging ◽  
Free Breathing ◽  
Mr Spectroscopic Imaging

Rapid MR spectroscopic imaging of lactate using compressed sensing

2015 ◽  
Author(s):  
Rohini Vidya Shankar ◽  
Shubhangi Agarwal ◽  
Sairam Geethanath ◽  
Vikram D. Kodibagkar
Keyword(s):  
Compressed Sensing ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging

Undersampling strategies for compressed sensing accelerated MR spectroscopic imaging

2017 ◽  
Author(s):  
Rohini Vidya Shankar ◽  
Houchun Harry Hu ◽  
Nutandev Bikkamane Jayadev ◽  
John C. Chang ◽  
Vikram D. Kodibagkar
Keyword(s):  
Compressed Sensing ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging

scholarly journals Accelerated high-bandwidth MR spectroscopic imaging using compressed sensing

2016 ◽  
Vol 76 (2) ◽  
pp. 369-379 ◽  
Author(s):  
Peng Cao ◽  
Peter J. Shin ◽  
Ilwoo Park ◽  
Chloe Najac ◽  
Irene Marco-Rius ◽  
...  
Keyword(s):  
Compressed Sensing ◽  
Spectroscopic Imaging ◽  
High Bandwidth ◽  
Mr Spectroscopic Imaging

MTF behavior of compressed sensing MR spectroscopic imaging

2013 ◽  
Vol 40 (5) ◽  
pp. 052302 ◽  
Author(s):  
A. A. Heikal ◽  
K. Wachowicz ◽  
B. G. Fallone
Keyword(s):  
Compressed Sensing ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging

scholarly journals Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging

2013 ◽  
Vol 229 ◽  
pp. 187-197 ◽  
Author(s):  
Sarah J. Nelson ◽  
Eugene Ozhinsky ◽  
Yan Li ◽  
Il woo Park ◽  
Jason Crane
Keyword(s):  
Spectroscopic Imaging ◽  
Hyperpolarized 13C ◽  
Mr Spectroscopic Imaging

scholarly journals Preoperative Imaging of Glioblastoma Patients using Hyperpolarized 13C Pyruvate: Potential Role in Clinical Decision Making

2021 ◽  
Author(s):  
Jun Chen ◽  
Toral R Patel ◽  
Marco C Pinho ◽  
Changho Choi ◽  
Crystal E Harrison ◽  
...  
Keyword(s):  
Clinical Decision Making ◽  
Surgical Navigation ◽  
Tumor Resection ◽  
Lactate Production ◽  
Spectroscopic Imaging ◽  
Preoperative Imaging ◽  
Dual Frequency ◽  
Who Grade ◽  
Hyperpolarized 13C ◽  
Mr Spectroscopic Imaging

Abstract Background Glioblastoma remains incurable despite treatment with surgery, radiation therapy, and cytotoxic chemotherapy, prompting the search for a metabolic pathway unique to glioblastoma cells. 13C MR spectroscopic imaging with hyperpolarized pyruvate can demonstrate alterations in pyruvate metabolism in these tumors. Methods Three patients with diagnostic MRI suggestive of a glioblastoma were scanned at 3T 1-2 days prior to tumor resection using a 13C/ 1H dual-frequency RF coil and a 13C/ 1H-integrated MR protocol, which consists of a series of 1H MR sequences (T2 FLAIR, arterial spin labeling and contrast-enhanced (CE) T1) and 13C spectroscopic imaging with hyperpolarized [1- 13C]pyruvate. Dynamic spiral chemical shift imaging was used for 13C data acquisition. Surgical navigation was used to correlate the locations of tissue samples submitted for histology with the changes seen on the diagnostic MR scans and the 13C spectroscopic images. Results Each tumor was histologically confirmed to be a WHO grade IV glioblastoma with isocitrate dehydrogenase wild type. Total hyperpolarized 13C signals detected near the tumor mass reflected altered tissue perfusion near the tumor. For each tumor, a hyperintense [1- 13C]lactate signal was detected both within CE and T2-FLAIR regions on the 1H diagnostic images (p = 0.008). [ 13C]Bicarbonate signal was maintained or decreased in the lesion but the observation was not significant (p = 0.3). Conclusions Prior to surgical resection, 13C MR spectroscopic imaging with hyperpolarized pyruvate reveals increased lactate production in regions of histologically confirmed glioblastoma.

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