scholarly journals q-space and conventional diffusion imaging of axon and myelin damage in the rat spinal cord after axotomy

2010 ◽  
Vol 63 (5) ◽  
pp. 1323-1335 ◽  
Author(s):  
Jonathan A. D. Farrell ◽  
Jiangyang Zhang ◽  
Melina V. Jones ◽  
Cynthia A. DeBoy ◽  
Paul N. Hoffman ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Diffusion Imaging ◽  
Rat Spinal Cord ◽  
Myelin Damage

scholarly journals Prolonged Subdural Infusion of Kynurenic Acid Is Associated with Dose-Dependent Myelin Damage in the Rat Spinal Cord

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0142598 ◽  
Author(s):  
Wojciech Dabrowski ◽  
Jacek M. Kwiecien ◽  
Radoslaw Rola ◽  
Michal Klapec ◽  
Greg J. Stanisz ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Kynurenic Acid ◽  
Rat Spinal Cord ◽  
Dose Dependent ◽  
Myelin Damage

An Early Developmental Marker for Radial Glia in Rat Spinal Cord

1996 ◽  
Vol 54 ◽  
pp. 36-37
Author(s):  
V. Kriho ◽  
H.-Y. Yang ◽  
C.-M. Lue ◽  
N. Lieska ◽  
G. D. Pappas
Keyword(s):  
Spinal Cord ◽  
Intermediate Filament ◽  
Radial Glia ◽  
Rat Spinal Cord ◽  
Future Studies ◽  
Spinal Cord Development ◽  
Median Septum ◽  
Differentiation Marker ◽  
Early Developmental ◽  
Developing Rat

Radial glia have been classically defined as those early glial cells that radially span their thin processes from the ventricular to the pial surfaces in the developing central nervous system. These radial glia constitute a transient cell population, disappearing, for the most part, by the end of the period of neuronal migration. Traditionally, it has been difficult to definitively identify these cells because the principal criteria available were morphologic only.Using immunofluorescence microscopy, we have previously defined a phenotype for radial glia in rat spinal cord based upon the sequential expression of vimentin, glial fibrillary acidic protein and an intermediate filament-associated protein, IFAP-70/280kD. We report here the application of another intermediate filament-associated protein, IFAP-300kD, originally identified in BHK-21 cells, to the immunofluorescence study of radial glia in the developing rat spinal cord.Results showed that IFAP-300kD appeared very early in rat spinal cord development. In fact by embryonic day 13, IFAP-300kD immunoreactivity was already at its peak and was observed in most of the radial glia which span the spinal cord from the ventricular to the subpial surfaces (Fig. 1). Interestingly, from this time, IFAP-300kD immunoreactivity diminished rapidly in a dorsal to ventral manner, so that by embryonic day 16 it was detectable only in the maturing macroglial cells in the marginal zone of the spinal cord and the dorsal median septum (Fig. 2). By birth, the spinal cord was essentially immuno-negative for this IFAP. Thus, IFAP-300kD appears to be another differentiation marker available for future studies of gliogenesis, especially for the early stages of radial glia differentiation.

Sign in / Sign up

Export Citation Format

Share Document