scholarly journals Fast prospective registration of in vivo MR images of trabecular bone microstructure in longitudinal studies

2008 ◽  
Vol 59 (5) ◽  
pp. 1120-1126 ◽  
Author(s):  
Chamith S. Rajapakse ◽  
Jeremy F. Magland ◽  
Felix W. Wehrli
Keyword(s):  
Trabecular Bone ◽  
Longitudinal Studies ◽  
Bone Microstructure ◽  
Mr Images ◽  
Trabecular Bone Microstructure

A Microstructural Finite Element Simulation of Mechanically Induced Bone Formation

2001 ◽  
Vol 123 (6) ◽  
pp. 607-612 ◽  
Author(s):  
John T. Koontz ◽  
Guillaume T. Charras ◽  
Robert E. Guldberg
Keyword(s):  
Finite Element ◽  
Bone Formation ◽  
Trabecular Bone ◽  
Bone Repair ◽  
Bone Microstructure ◽  
Principal Strain ◽  
Physical Factors ◽  
Objective Criterion ◽  
Trabecular Bone Microstructure

A finite element method to simulate the formation of an interconnected trabecular bone microstructure oriented with respect to applied in vivo mechanical forces is introduced and quantitatively compared to experimental data from a hydraulic bone chamber implant model. Randomly located 45 μm mineralized nodules were used as the initial condition for the model simulations to represent an early stage of intramembranous bone formation. Boundary conditions were applied consistent with the mechanical environment provided by the in vivo bone chamber model. A two-dimensional repair simulation algorithm that incorporated strain energy density (SED), SED gradient, principal strain, or principal strain gradient as the local objective criterion was utilized to simulate the formation of an oriented trabecular bone microstructure. The simulation solutions were convergent, unique, and relatively insensitive to the assumed initial distribution of mineralized nodules. Model predictions of trabecular bone morphology and anisotropy were quantitatively compared to experimental results. All simulations produced structures that qualitatively resembled oriented trabecular bone. However, only simulations utilizing a gradient objective criterion yielded results quantitatively similar to in vivo observations. This simulation approach coupled with an experimental model that delivers controlled in vivo mechanical stimuli can be utilized to study the relationship between physical factors and microstructural adaptation during bone repair.

scholarly journals Sexual Dimorphism in Cortical and Trabecular Bone Microstructure Appears During Puberty in Chinese Children

2018 ◽  
Vol 33 (11) ◽  
pp. 1948-1955 ◽  
Author(s):  
Ka Yee Cheuk ◽  
Xiao-Fang Wang ◽  
Ji Wang ◽  
Zhendong Zhang ◽  
Fiona Wai Ping Yu ◽  
...  
Keyword(s):  
Sexual Dimorphism ◽  
Trabecular Bone ◽  
Bone Microstructure ◽  
Chinese Children ◽  
Trabecular Bone Microstructure

scholarly journals BMD-Related Genetic Risk Scores Predict Site-Specific Fractures as Well as Trabecular and Cortical Bone Microstructure

2020 ◽  
Vol 105 (4) ◽  
pp. e1344-e1357 ◽  
Author(s):  
Maria Nethander ◽  
Ulrika Pettersson-Kymmer ◽  
Liesbeth Vandenput ◽  
Mattias Lorentzon ◽  
Magnus Karlsson ◽  
...  
Keyword(s):  
Trabecular Bone ◽  
Cortical Bone ◽  
Hip Fractures ◽  
Vertebral Fractures ◽  
Genetic Risk ◽  
Bone Microstructure ◽  
Risk Scores ◽  
Site Specific ◽  
Microstructure Parameters ◽  
Trabecular Bone Microstructure

Abstract Context It is important to identify patients at highest risk of fractures. Objective To compare the separate and combined performances of bone-related genetic risk scores (GRSs) for prediction of forearm, hip and vertebral fractures separately, as well as of trabecular and cortical bone microstructure parameters separately. Design, Setting, and Participants Using 1103 single nucleotide polymorphisms (SNPs) independently associated with estimated bone mineral density of the heel (eBMD), we developed a weighted GRS for eBMD and determined its contribution to fracture prediction beyond 2 previously developed GRSs for femur neck BMD (49 SNPs) and lumbar spine BMD (48 SNPs). Associations between these GRSs and forearm (ncases = 1020; ncontrols = 2838), hip (ncases = 1123; ncontrols = 2630) and vertebral (ncases = 288; ncontrols = 1187) fractures were evaluated in 3 Swedish cohorts. Associations between the GRSs and trabecular and cortical bone microstructure parameters (n = 426) were evaluated in the MrOS Sweden cohort. Results We found that eBMDGRS was the only significant independent predictor of forearm and vertebral fractures while both FN-BMDGRS and eBMDGRS were significant independent predictors of hip fractures. The eBMDGRS was the major GRS contributing to prediction of trabecular bone microstructure parameters while both FN-BMDGRS and eBMDGRS contributed information for prediction of cortical bone microstructure parameters. Conclusions The eBMDGRS independently predicts forearm and vertebral fractures while both FN-BMDGRS and eBMDGRS contribute independent information for prediction of hip fractures. We propose that eBMDGRS captures unique information about trabecular bone microstructure useful for prediction of forearm and vertebral fractures. These findings may facilitate personalized medicine to predict site-specific fractures as well as cortical and trabecular bone microstructure separately.

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