scholarly journals 1.4T study of proton magnetic relaxation rates, iron concentrations, and plaque burden in Alzheimer's disease and control postmortem brain tissue

2008 ◽  
Vol 60 (1) ◽  
pp. 41-52 ◽  
Author(s):  
Michael J. House ◽  
Timothy G. St. Pierre ◽  
Catriona McLean
Keyword(s):  
Alzheimer’S Disease ◽  
Brain Tissue ◽  
Magnetic Relaxation ◽  
Postmortem Brain ◽  
Plaque Burden ◽  
Relaxation Rates ◽  
Postmortem Brain Tissue ◽  
Proton Magnetic Relaxation ◽  
And Control ◽  
Iron Concentrations

scholarly journals Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patients

2006 ◽  
Vol 57 (1) ◽  
pp. 172-180 ◽  
Author(s):  
Michael J. House ◽  
Timothy G. St. Pierre ◽  
Kris V. Kowdley ◽  
Thomas Montine ◽  
James Connor ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Tissue ◽  
Postmortem Brain ◽  
Relaxation Rates ◽  
Transverse Relaxation ◽  
Postmortem Brain Tissue ◽  
Iron Concentrations

P3-126: USING RNA-SEQ TO IDENTIFY RNA EDITING IN CONTROL AND ALZHEIMER'S DISEASE POSTMORTEM BRAIN TISSUE

2006 ◽  
Vol 14 (7S_Part_21) ◽  
pp. P1115-P1116
Author(s):  
Sharvari Vadeyar ◽  
Francesca North ◽  
James Turton ◽  
Tamar Guetta-Baranes ◽  
Sally Chappell ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Tissue ◽  
Rna Editing ◽  
Postmortem Brain ◽  
Rna Seq ◽  
Postmortem Brain Tissue

Relevance of a Truncated PRESENILIN 2 Transcript to Alzheimer’s Disease and Neurodegeneration

2021 ◽  
Vol 80 (4) ◽  
pp. 1479-1489
Author(s):  
Seyyed Hani Moussavi Nik ◽  
Tenielle Porter ◽  
Morgan Newman ◽  
Benjamin Bartlett ◽  
Imran Khan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Tissue ◽  
Linear Regression Analysis ◽  
Digital Pcr ◽  
Postmortem Brain ◽  
Imaging Biomarker ◽  
Control Group ◽  
Transcript Levels ◽  
Postmortem Brain Tissue

Background: The PRESENILIN genes (PSEN1, PSEN2) encoding for their respective proteins have critical roles in many aspects of Alzheimer’s disease (AD) pathogenesis. The PS2V transcript of PSEN2 encodes a truncated protein and is upregulated in AD brains; however, its relevance to AD and disease progression remains to be determined. Objective: Assess transcript levels in postmortem AD and non-AD brain tissue and in lymphocytes collected under the Australian Imaging Biomarker and Lifestyle (AIBL) study. Methods: Full length PSEN2 and PS2V transcript levels were assessed by quantitative digital PCR in postmortem brain tissue (frontal cortex and hippocampus) from control, AD, frontotemporal dementia (FTD), and Lewy body dementia (LBD). Transcript levels were also assessed in lymphocytes obtained from the Perth subset of the AIBL study (n = 160). Linear regression analysis was used to assess correlations between transcript copy number and brain volume and neocortical amyloid load. Results: PS2V levels increased in AD postmortem brain but PS2V was also present at significant levels in FTD and LBD brains. PS2V transcript was detected in lymphocytes and PS2V/PSEN2 ratios were increased in mild cognitive impairment (p = 0.024) and AD (p = 0.019) groups compared to control group. Increased ratios were significantly correlated with hippocampal volumes only (n = 62, β= –0.269, p = 0.03). Conclusion: Taken together, these results suggest that PS2V may be a marker of overall neurodegeneration.

BACE1 mRNA Expression in Alzheimer's Disease Postmortem Brain Tissue

2011 ◽  
Vol 22 (4) ◽  
pp. 1111-1122 ◽  
Author(s):  
David T.R. Coulson ◽  
Nancy Beyer ◽  
Joe G. Quinn ◽  
Simon Brockbank ◽  
Jan Hellemans ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mrna Expression ◽  
Brain Tissue ◽  
Postmortem Brain ◽  
Postmortem Brain Tissue
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