scholarly journals Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T

2007 ◽  
Vol 58 (5) ◽  
pp. 886-892 ◽  
Author(s):  
Yan Li ◽  
Albert P. Chen ◽  
Jason C. Crane ◽  
Susan M. Chang ◽  
Daniel B. Vigneron ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Brain Tumors ◽  
Three Dimensional ◽  
Spectroscopic Imaging ◽  
Magnetic Resonance Spectroscopic Imaging

Three-dimensional magnetic resonance spectroscopic imaging of histologically confirmed brain tumors

2001 ◽  
Vol 19 (1) ◽  
pp. 89-101 ◽  
Author(s):  
Daniel Vigneron ◽  
Andrew Bollen ◽  
Michael McDermott ◽  
Lawrence Wald ◽  
Mark Day ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Brain Tumors ◽  
Three Dimensional ◽  
Spectroscopic Imaging ◽  
Magnetic Resonance Spectroscopic Imaging

Proton Magnetic Resonance Spectroscopic Imaging in Children With Recurrent Primary Brain Tumors

2000 ◽  
Vol 18 (5) ◽  
pp. 1020-1020 ◽  
Author(s):  
Katherine E. Warren ◽  
Joseph A. Frank ◽  
Jeanette L. Black ◽  
Rene S. Hill ◽  
Josef H. Duyn ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Brain Tumors ◽  
Biochemical Markers ◽  
Proton Magnetic Resonance ◽  
Spectroscopic Imaging ◽  
Magnetic Resonance Spectroscopic Imaging ◽  
Investigational Drug ◽  
Tumor Type ◽  
Histologic Subtype ◽  
Primary Brain Tumors

PURPOSE: Proton magnetic resonance spectroscopic imaging (1H-MRSI) is a noninvasive technique for spatial characterization of biochemical markers in tissues. We measured the relative tumor concentrations of these biochemical markers in children with recurrent brain tumors and evaluated their potential prognostic significance. PATIENTS AND METHODS: 1H-MRSI was performed on 27 children with recurrent primary brain tumors referred to our institution for investigational drug trials. Diagnoses included high-grade glioma (n = 10), brainstem glioma (n = 7), medulloblastoma/peripheral neuroectodermal tumor (n = 6), ependymoma (n = 3), and pineal germinoma (n = 1). 1H-MRSI was performed on 1.5-T magnetic resonance imagers before treatment. The concentrations of choline (Cho) and N-acetyl-aspartate (NAA) in the tumor and normal brain were quantified using a multislice multivoxel method, and the maximum Cho:NAA ratio was determined for each patient’s tumor. RESULTS: The maximum Cho:NAA ratio ranged from 1.1 to 13.2 (median, 4.5); the Cho:NAA ratio in areas of normal-appearing brain tissue was less than 1.0. The maximum Cho:NAA ratio for each histologic subtype varied considerably; approximately equal numbers of patients within each tumor type had maximum Cho:NAA ratios above and below the median. Patients with a maximum Cho:NAA ratio greater than 4.5 had a median survival of 22 weeks, and all 13 patients died by 63 weeks. Patients with a Cho:NAA ratio less than or equal to 4.5 had a projected survival of more than 50% at 63 weeks. The difference was statistically significant (P = .0067, log-rank test). CONCLUSION: The maximum tumor Cho:NAA ratio seems to be predictive of outcome in children with recurrent primary brain tumors and should be evaluated as a prognostic indicator in newly diagnosed childhood brain tumors.

Elliptical magnetic resonance spectroscopic imaging with GRAPPA for imaging brain tumors at 3 T

2009 ◽  
Vol 27 (10) ◽  
pp. 1319-1325 ◽  
Author(s):  
Suchandrima Banerjee ◽  
Esin Ozturk-Isik ◽  
Sarah J. Nelson ◽  
Sharmila Majumdar
Keyword(s):  
Magnetic Resonance ◽  
Brain Tumors ◽  
Spectroscopic Imaging ◽  
Magnetic Resonance Spectroscopic Imaging

Noninvasive Magnetic Resonance Spectroscopic Imaging Biomarkers to Predict the Clinical Grade of Pediatric Brain Tumors

2004 ◽  
Vol 10 (24) ◽  
pp. 8220-8228 ◽  
Author(s):  
Loukas G. Astrakas ◽  
David Zurakowski ◽  
A. Aria Tzika ◽  
Maria K. Zarifi ◽  
Douglas C. Anthony ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Brain Tumors ◽  
Spectroscopic Imaging ◽  
Pediatric Brain Tumors ◽  
Magnetic Resonance Spectroscopic Imaging ◽  
Imaging Biomarkers ◽  
Clinical Grade ◽  
Pediatric Brain
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