scholarly journals Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice

2006 ◽  
Vol 56 (3) ◽  
pp. 698-703 ◽  
Author(s):  
Shigeto Kubo ◽  
Elena Levantini ◽  
Susumu Kobayashi ◽  
Olivier Kocher ◽  
Balazs Halmos ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Transgenic Mice ◽  
Three Dimensional ◽  
Magnetic Resonance Microscopy

scholarly journals Vascular phenotyping of brain tumors using magnetic resonance microscopy (μMRI)

2011 ◽  
Vol 31 (7) ◽  
pp. 1623-1636 ◽  
Author(s):  
Eugene Kim ◽  
Jiangyang Zhang ◽  
Karen Hong ◽  
Nicole E Benoit ◽  
Arvind P Pathak
Keyword(s):  
Brain Tumor ◽  
Magnetic Resonance ◽  
Brain Tumors ◽  
Three Dimensional ◽  
Region Of Interest ◽  
Tumor Model ◽  
Magnetic Resonance Microscopy ◽  
Vascular Phenotype ◽  
Brain Tumor Model ◽  
Novel Method

Abnormal vascular phenotypes have been implicated in neuropathologies ranging from Alzheimer's disease to brain tumors. The development of transgenic mouse models of such diseases has created a crucial need for characterizing the murine neurovasculature. Although histologic techniques are excellent for imaging the microvasculature at submicron resolutions, they offer only limited coverage. It is also challenging to reconstruct the three-dimensional (3D) vasculature and other structures, such as white matter tracts, after tissue sectioning. Here, we describe a novel method for 3D whole-brain mapping of the murine vasculature using magnetic resonance microscopy (μMRI), and its application to a preclinical brain tumor model. The 3D vascular architecture was characterized by six morphologic parameters: vessel length, vessel radius, microvessel density, length per unit volume, fractional blood volume, and tortuosity. Region-of-interest analysis showed significant differences in the vascular phenotype between the tumor and the contralateral brain, as well as between postinoculation day 12 and day 17 tumors. These results unequivocally show the feasibility of using μMRI to characterize the vascular phenotype of brain tumors. Finally, we show that combining these vascular data with coregistered images acquired with diffusion-weighted MRI provides a new tool for investigating the relationship between angiogenesis and concomitant changes in the brain tumor microenvironment.

scholarly journals In vivo continuous three-dimensional magnetic resonance microscopy: a study of metamorphosis in Carniolan worker honey bees (Apis mellifera carnica)

2020 ◽  
Vol 223 (21) ◽  
pp. jeb225250
Author(s):  
Aleš Mohorič ◽  
Janko Božič ◽  
Polona Mrak ◽  
Kaja Tušar ◽  
Chenyun Lin ◽  
...  
Keyword(s):  
Apis Mellifera ◽  
Magnetic Resonance ◽  
Time Course ◽  
Three Dimensional ◽  
The Body ◽  
Magnetic Resonance Microscopy ◽  
Tracheal System ◽  
Apis Mellifera Carnica ◽  
Occurrence Matrix

ABSTRACTThree-dimensional (3D) magnetic resonance microscopy (MRM) is a modality of magnetic resonance imaging (MRI) optimized for the best resolution. Metamorphosis of the Carniolan worker honey bee (Apis mellifera carnica) was studied in vivo under controlled temperature and humidity conditions from sealed larvae until the emergence of an adult. The 3D images were analyzed by volume rendering and segmentation, enabling the analysis of the body, tracheal system and gastrointestinal tract through the time course of volume changes. Fat content sensitivity enabled the analysis of flight muscles transformation during the metamorphosis by the signal histogram and gray level co-occurrence matrix (GLCM). Although the transformation during metamorphosis is well known, MRM enables an alternative insight to this process, i.e. 3D in vivo, which has relatively high spatial and temporal resolutions. The developed methodology can easily be adapted for studying the metamorphosis of other insects or any other incremental biological process on a similar spatial and temporal scale.

A three-dimensional digital atlas database of the adult C57BL/6J mouse brain by magnetic resonance microscopy

Neuroscience ◽  
2005 ◽  
Vol 135 (4) ◽  
pp. 1203-1215 ◽  
Author(s):  
Y. Ma ◽  
P.R. Hof ◽  
S.C. Grant ◽  
S.J. Blackband ◽  
R. Bennett ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Mouse Brain ◽  
Three Dimensional ◽  
Magnetic Resonance Microscopy ◽  
Digital Atlas

scholarly journals P1-114: In vivo amyloid plaque detection using contrast-enhanced magnetic resonance microscopy in transgenic mice

2009 ◽  
Vol 5 (4S_Part_7) ◽  
pp. P208-P209
Author(s):  
Alexandra Petiet ◽  
Anne Bertrand ◽  
Christopher Wiggins ◽  
Diane Houitte ◽  
Thomas Debeir ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Transgenic Mice ◽  
Amyloid Plaque ◽  
Magnetic Resonance Microscopy ◽  
Contrast Enhanced ◽  
Plaque Detection

IC-P-006: In vivo amyloid plaque detection using contrast-enhanced magnetic resonance microscopy in transgenic mice

2009 ◽  
Vol 5 (4S_Part_1) ◽  
pp. P8-P8
Author(s):  
Alexandra Petiet ◽  
Anne Bertrand ◽  
Christopher Wiggins ◽  
Diane Houitte ◽  
Thomas Debeir ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Transgenic Mice ◽  
Amyloid Plaque ◽  
Magnetic Resonance Microscopy ◽  
Contrast Enhanced ◽  
Plaque Detection

The architecture of plant vasculature and transport as seen with magnetic resonance microscopy

1994 ◽  
Vol 72 (11) ◽  
pp. 1561-1573 ◽  
Author(s):  
Janet S. MacFall ◽  
G. A. Johnson
Keyword(s):  
Magnetic Resonance ◽  
Three Dimensional ◽  
Magnetic Resonance Microscopy ◽  
Kiwi Fruit ◽  
Sugar Beets ◽  
Potato Plants ◽  
The Past ◽  
High Concentrations ◽  
Anatomical Information ◽  
Key Words Transport

Water and photosynthate transport through plants has been studied extensively for the past three centuries. Few techniques are available that are capable of providing both physiological and anatomical information, and most are destructive in nature. We report the use of high resolution magnetic resonance microscopy (MRM) for the study of intact plant vasculature. Both two- (2-D) and three-dimensional (3-D) image acquisition protocols are employed wherein the plant vasculature can be readily distinguished from surrounding parenchymal tissue. In the 3-D image sets, the vasculature has been digitally segmented, allowing isolation of only the intact vascular architecture. The paths of water and photosynthate transport into several plant specimens have been visualized in this manner. Images of sugar beets, plants that store high concentrations of sucrose within the parenchyma, show contrast patterns between vasculature and parenchyma that are opposite to those seen in images acquired of an apple, fig, okra pod, kiwi fruit, and potato, plants that do not store high concentrations of sucrose. This suggests that transport and accumulation of photosynthates may be partially responsible for contrasts seen within images acquired of these plant specimens. Key words: transport, transpiration, sugar, MRI, magnetic resonance imaging, plants.

Sign in / Sign up

Export Citation Format

Share Document