Toward quantitative short-echo-time in vivo proton MR spectroscopy without water suppression

2006 ◽  
Vol 55 (6) ◽  
pp. 1441-1446 ◽  
Author(s):  
Zhengchao Dong ◽  
Wolfgang Dreher ◽  
Dieter Leibfritz
Keyword(s):  
Mr Spectroscopy ◽  
Water Suppression ◽  
Proton Mr Spectroscopy ◽  
Echo Time ◽  
Short Echo Time

scholarly journals Localized short-echo-time proton MR spectroscopy with full signal-intensity acquisition

2006 ◽  
Vol 56 (5) ◽  
pp. 965-970 ◽  
Author(s):  
Vladimír Mlynárik ◽  
Giulio Gambarota ◽  
Hanne Frenkel ◽  
Rolf Gruetter
Keyword(s):  
Mr Spectroscopy ◽  
Signal Intensity ◽  
Proton Mr Spectroscopy ◽  
Echo Time ◽  
Short Echo Time

Single Voxel Proton MR Spectroscopy Methods and Applications in Neuropediatrics

2000 ◽  
Vol 13 (1) ◽  
pp. 7-15
Author(s):  
J. Frahm ◽  
F. Hanefeld
Keyword(s):  
Mr Spectroscopy ◽  
Total N ◽  
Proton Mr Spectroscopy ◽  
Promising Tool ◽  
Single Voxel ◽  
Localization Sequence ◽  
Short Echo Time ◽  
Clinical Potential ◽  
Pathologic Processes

The purpose of this contribution is to introduce quantitative single voxel proton MR spectroscopy of the human brain as an easy-to-use method for a noninvasive assessment of cellular composition and metabolism and to demonstrate its clinical potential in the field of neuropediatrics. The chosen approach transforms fully relaxed (TR = 6000 ms) short echo time (TE = 20 ms) proton MR spectra (STEAM localization sequence) into absolute metabolite concentrations by automatically fitting the raw data with a library of model spectra comprising all metabolites at known concentration (LCModel). The procedure includes total N-acetylaspartyl compounds as a marker for viable neuroaxonal tissue and myo-inositol as a purely glial constituent as well as total creatine, choline-containing compounds, glutamate and glutamine, and lactate. Extensive studies of brain disorders in childhood suggest the use of proton MRS as a promising tool for an in vivo histopathologic characterization of brain tissue. Typical metabolite patterns are observed for pathologic processes such as lactic acidosis, loss of functioning neurons, astrocytosis, myelin breakdown, or loss of oligodendrocytes. Examples deal with the diagnostic workup of enzyme deficiencies, demyelinating white matter diseases, and focal brain lesions.

Measurement of Lipid Content in Gallbladder Bile Using in- and opposed-phase MR Images and in vivo Proton MR Spectroscopy

2002 ◽  
Vol 46 (2) ◽  
pp. 127
Author(s):  
Sun Jin Hur ◽  
Seok Hwan Shin ◽  
Geum Nan Jee ◽  
Eun Joo Yun ◽  
Soon Gu Cho ◽  
...  
Keyword(s):  
Lipid Content ◽  
Mr Spectroscopy ◽  
Gallbladder Bile ◽  
Mr Images ◽  
Proton Mr Spectroscopy

Salivary Gland Tumors at in Vivo Proton MR Spectroscopy

Radiology ◽  
2005 ◽  
Vol 237 (2) ◽  
pp. 563-569 ◽  
Author(s):  
Ann D. King ◽  
David K. W. Yeung ◽  
Anil T. Ahuja ◽  
Gary M. K. Tse ◽  
H. Y. Yuen ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Mr Spectroscopy ◽  
Salivary Gland Tumors ◽  
Proton Mr Spectroscopy

In-vivo proton MR-spectroscopy of the human brain: Assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration

Amino Acids ◽  
2002 ◽  
Vol 23 (1-3) ◽  
pp. 317-323 ◽  
Author(s):  
W. Block ◽  
F. Träber ◽  
S. Flacke ◽  
F. Jessen ◽  
C. Pohl ◽  
...  
Keyword(s):  
Human Brain ◽  
Mr Spectroscopy ◽  
Proton Mr Spectroscopy
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