Magnetic resonance imaging image intensity correction with extrapolation and adaptive smoothing

2006 ◽  
Vol 55 (4) ◽  
pp. 959-966 ◽  
Author(s):  
Hu Cheng ◽  
Feng Huang
2021 ◽  
Vol 83 ◽  
pp. 79-87
Author(s):  
Javier Montalt-Tordera ◽  
Vivek Muthurangu ◽  
Andreas Hauptmann ◽  
Jennifer Anne Steeden

2017 ◽  
Vol 7 (6) ◽  
pp. 1149-1152 ◽  
Author(s):  
Yew Wansin ◽  
Mohd Juzaila Abd. Latif ◽  
Norhashimah Mohd Saad ◽  
Sharifah Majedah Idrus Alhabshi ◽  
Mohammed Rafiq Abdul Kadir

1994 ◽  
Vol 14 (6) ◽  
pp. 1011-1023 ◽  
Author(s):  
Menno van Lookeren Campagne ◽  
Jeroen B. Verheul ◽  
Klaas Nicolay ◽  
Robert Balázs

We explored the therapeutic potentials of two N-methyl-d-aspartate (NMDA) receptor antagonists in vivo using different techniques. NMDA injected into the striatum of neonatal rats (20 nmol/0.5 μl) induced a rapid increase in the diffusion-weighted (DW) image intensity, spreading over a large part of the ipsilateral hemisphere. Subcutaneous injection of the NMDA receptor antagonist MK-801 (1 mg/kg) or d-( E)-4-(3-phosphono-2-prop-enyl)-2-piperazine-carboxylic acid (D-CPPene; 1.5 mg/kg) reversed both the volume and the grading of the NMDA-induced hyperintensity of DW images, the reversal by MK-801 being more rapid than that by D-CPPene. In the cerebral cortex, there was an inverse relationship between changes in DW image intensity and the size of the extracellular space, assessed by electrical impedance measurements. The reduction of the hyperintense volume in DW images 1 or 2 h after MK-801 or D-CPPene treatment of NMDA-injected animals depended on the type of antagonist used and on the interval between intrastriatal NMDA injection and antagonist treatment. The reduction was 95% when MK-801 was given with a delay of 90 min and decreased to 20% when it was given at 360 min. With D-CPPene, the reduction was 80% after a delay of 30 min and virtually absent when it was administered at 360 min. Quantitative analysis showed significant correlations between the residual hyperintense volume 1 or 2 h after MK-801 or D-CPPene treatment and the final lesion volume, assessed from either T2-weighted images ( R = 0.89, p < 0.001) or histology ( R = 0.80, p < 0.001) 5 days after the insult. This study illustrates the sensitivity of DW magnetic resonance imaging to monitor in vivo early events after an excitotoxic insult and the effect of putative protective drugs that may counteract the resulting damage.


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