scholarly journals Two-dimensional, J-resolved spectroscopic imaging of GABA at 4 Tesla in the human brain

2005 ◽  
Vol 54 (4) ◽  
pp. 783-788 ◽  
Author(s):  
J. Eric Jensen ◽  
Blaise deB. Frederick ◽  
Liqun Wang ◽  
John Brown ◽  
Perry F. Renshaw
Keyword(s):  
Human Brain ◽  
Spectroscopic Imaging ◽  
Two Dimensional

Grey and white matter GABA level differences in the human brain using two-dimensional,J-resolved spectroscopic imaging

2005 ◽  
Vol 18 (8) ◽  
pp. 570-576 ◽  
Author(s):  
J. Eric Jensen ◽  
Blaise deB. Frederick ◽  
Perry F. Renshaw
Keyword(s):  
White Matter ◽  
Human Brain ◽  
Spectroscopic Imaging ◽  
Two Dimensional ◽  
Gaba Level

In Vivo 1H MR Spectroscopic Imaging of Human Brain

1994 ◽  
Vol 31 (2) ◽  
pp. 185
Author(s):  
Yong Whee Bahk ◽  
Kyung Sub Shinn ◽  
Tae Suk Suh ◽  
Bo Young Choe ◽  
Kyo Ho Choi
Keyword(s):  
Human Brain ◽  
Spectroscopic Imaging ◽  
Mr Spectroscopic Imaging

Two-dimensional map of human brain proteins

1999 ◽  
Vol 20 (4-5) ◽  
pp. 907-916 ◽  
Author(s):  
Hanno Langen ◽  
Peter Berndt ◽  
Daniel Röder ◽  
Nigel Cairns ◽  
Gert Lubec ◽  
...  
Keyword(s):  
Human Brain ◽  
Two Dimensional ◽  
Brain Proteins

scholarly journals Emerging methods and applications of ultra-high field MR spectroscopic imaging in the human brain

2021 ◽  
pp. 114479
Author(s):  
Gilbert Hangel ◽  
Eva Heckova ◽  
Philipp Lazen ◽  
Petr Bednarik ◽  
Wolfgang Bogner ◽  
...  
Keyword(s):  
Human Brain ◽  
High Field ◽  
Spectroscopic Imaging ◽  
Ultra High Field ◽  
High Field Mr ◽  
Mr Spectroscopic Imaging

scholarly journals Structures of α-synuclein filaments from multiple system atrophy

2020 ◽  
Author(s):  
Manuel Schweighauser ◽  
Yang Shi ◽  
Airi Tarutani ◽  
Fuyuki Kametani ◽  
Alexey G. Murzin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Human Brain ◽  
Multiple System Atrophy ◽  
Recombinant Proteins ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Two Dimensional ◽  
Filamentous Inclusions

Synucleinopathies are human neurodegenerative diseases that include multiple system atrophy (MSA), Parkinson’s disease, Parkinson’s disease dementia (PDD) and dementia with Lewy bodies (DLB) (1). Existing treatments are at best symptomatic. These diseases are characterised by the presence in brain cells of filamentous inclusions of α-synuclein, the formation of which is believed to cause disease (2, 3). However, the structures of α-synuclein filaments from human brain are not known. Here we show, using electron cryo-microscopy, that α-synuclein inclusions from MSA are made of two types of filaments, each of which consists of two different protofilaments. Non-proteinaceous molecules are present at the protofilament interfaces. By two-dimensional class averaging, we show that α-synuclein filaments from the brains of patients with MSA and DLB are different, suggesting that distinct conformers (or strains) characterise synucleinopathies. As was the case of tau assemblies (4–9), the structures of α-synuclein filaments extracted from the brains of individuals with MSA differ from those formed in vitro using recombinant proteins, with implications for understanding the mechanisms of aggregate propagation and neurodegeneration in human brain. These findings have diagnostic and potential therapeutic relevance, especially in view of the unmet clinical need to be able to image filamentous α-synuclein inclusions in human brain.

Quantitative spectroscopic imaging of the human brain

1998 ◽  
Vol 40 (3) ◽  
pp. 363-369 ◽  
Author(s):  
Jullie W. Pan ◽  
Donald B. Twieg ◽  
Hoby P. Hetherington
Keyword(s):  
Human Brain ◽  
Spectroscopic Imaging

scholarly journals Regional Metabolite Concentrations in Aging Human Brain: Comparison of Short-TE Whole Brain MR Spectroscopic Imaging and Single Voxel Spectroscopy at 3T

2019 ◽  
Vol 30 (2) ◽  
pp. 251-261 ◽  
Author(s):  
Helen Maghsudi ◽  
Birte Schmitz ◽  
Andrew A. Maudsley ◽  
Sulaiman Sheriff ◽  
Paul Bronzlik ◽  
...  
Keyword(s):  
Human Brain ◽  
Spectroscopic Imaging ◽  
Whole Brain ◽  
Single Voxel ◽  
Metabolite Concentrations ◽  
Mr Spectroscopic Imaging

Two-dimensional gel electrophoresis of human brain proteins. I. Technique and nomenclature of proteins.

1982 ◽  
Vol 28 (4) ◽  
pp. 782-789 ◽  
Author(s):  
D E Comings
Keyword(s):  
Human Brain ◽  
Gel Electrophoresis ◽  
Urea Solution ◽  
Two Dimensional ◽  
Two Dimensional Gel Electrophoresis ◽  
Polypeptide Patterns ◽  
Normal Individuals ◽  
Molecular Masses ◽  
Group B ◽  
The Individual

Abstract To understand at a molecular level the basis of the normal and pathological genetic differences between individuals it is necessary to begin a detailed two-dimensional gel electrophoretic mapping of the proteins of the human brain in normal individuals and those with various genetic neurological disorders. The present study is an examination of the polypeptide patterns of extracts of the human brain made with 9 mol/L urea solution. Details of the technique and the nomenclature of the patterns obtained are presented. the gels are separated into 20 sub-sections, based on standards with known molecular masses and isoelectric points. Groups of polypeptides within these sub-sections are identified by a number and a letter; the individual proteins are identified by a number. Thus, protein 1 in subsection 8, group b, would be designated 8b: 1. Subsequent papers in this series identify many of these proteins; show which proteins belong to the cytosol, synaptosome, myelin, and other brain fractions; show how these patterns vary between normal individuals and those with different neurological and psychiatric conditions; examine the effect of severe gliosis; and present the results of non-equilibrium gel electrophoresis for the more basic proteins.

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