scholarly journals Quantification of perfusion fMRI using a numerical model of arterial spin labeling that accounts for dynamic transit time effects

2005 ◽  
Vol 54 (4) ◽  
pp. 955-964 ◽  
Author(s):  
Luis Hernandez-Garcia ◽  
Gregory R. Lee ◽  
Alberto L. Vazquez ◽  
Chun-Yu Yip ◽  
Douglas C. Noll
Keyword(s):  
Numerical Model ◽  
Transit Time ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Time Effects

scholarly journals Arterial transit time effects in pulsed arterial spin labeling CBF mapping: Insight from a PET and MR study in normal human subjects

2010 ◽  
Vol 63 (2) ◽  
pp. 374-384 ◽  
Author(s):  
Maolin Qiu ◽  
R. Paul Maguire ◽  
Jagriti Arora ◽  
Beata Planeta-Wilson ◽  
David Weinzimmer ◽  
...  
Keyword(s):  
Transit Time ◽  
Arterial Spin Labeling ◽  
Human Subjects ◽  
Spin Labeling ◽  
Time Effects ◽  
Normal Human ◽  
Arterial Transit Time ◽  
Mr Study

scholarly journals Arterial spin labeling and dynamic susceptibility contrast CBF MRI in postischemic hyperperfusion, hypercapnia, and after mannitol injection

2010 ◽  
Vol 31 (6) ◽  
pp. 1403-1411 ◽  
Author(s):  
Yoji Tanaka ◽  
Tsukasa Nagaoka ◽  
Govind Nair ◽  
Kikuo Ohno ◽  
Timothy Q Duong
Keyword(s):  
Transit Time ◽  
Arterial Spin Labeling ◽  
Lattice Relaxation ◽  
Spin Labeling ◽  
Spin Lattice Relaxation ◽  
Dynamic Susceptibility ◽  
Dynamic Susceptibility Contrast ◽  
Group I ◽  
Bbb Permeability ◽  
Susceptibility Contrast

Arterial spin labeling (ASL) and dynamic susceptibility contrast (DSC) magnetic resonance imaging (MRI) are widely used to image cerebral blood flow (CBF) in stroke. This study examined how changes in tissue spin-lattice relaxation-time constant ( T1), blood-brain barrier (BBB) permeability, and transit time affect CBF quantification by ASL and DSC in postischemic hyperperfusion in the same animals. In Group I ( n = 6), embolic stroke rats imaged 48hours after stroke showed regional hyperperfusion. In normal pixels, ASL- and DSC-CBF linearly correlated pixel-by-pixel. In hyperperfusion pixels, ASL-CBF was significantly higher than DSC-CBF pixel-by-pixel (by 25%). T1 increased from 1.76 ± 0.14 seconds in normal pixels to 1.93 ± 0.17 seconds in hyperperfusion pixels. Arterial transit time decreased from 300 milliseconds in normal pixels to 200 milliseconds in hyperperfusion pixels. Δ R2* profiles showed contrast-agent leakages in the hyperperfusion regions. In Group II ( n = 3) in which hypercapnic inhalation was used to increase CBF without BBB disruption, CBF increased overall but ASL- and DSC-CBF remained linearly correlated. In Group III ( n = 3) in which mannitol was used to break the BBB, ASL-CBF was significantly higher than DSC-CBF. We concluded that in normal tissue, ASL and DSC provide comparable quantitative CBF, whereas in postischemic hyperperfusion, ASL-CBF and DSC-CBF differed significantly because ischemia-induced changes in T1 and BBB permeability affected the two methods differently.

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