BOLD response to direct thalamic stimulation reveals a functional connection between the medial thalamus and the anterior cingulate cortex in the rat

2004 ◽  
Vol 52 (1) ◽  
pp. 47-55 ◽  
Author(s):  
Bai-Chung Shyu ◽  
Chun-Yu Lin ◽  
Jyh-Jang Sun ◽  
Shin-Lang Chen ◽  
Chen Chang
Keyword(s):  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Bold Response ◽  
Functional Connection ◽  
Medial Thalamus ◽  
Thalamic Stimulation

Thalamic Stimulation Activates The Anterior Cingulate Cortex in Chronic Pain Patients: A PET Study

NeuroImage ◽  
1998 ◽  
Vol 7 (4) ◽  
pp. S439 ◽  
Author(s):  
K.D. Davis ◽  
E. Taub ◽  
F. Duffner ◽  
A.M. Lozano ◽  
R.R. Tasker ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Anterior Cingulate Cortex ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Thalamic Stimulation ◽  
Chronic Pain Patients ◽  
Pain Patients

scholarly journals Electroacupuncture Improves IBS Visceral Hypersensitivity by Inhibiting the Activation of Astrocytes in the Medial Thalamus and Anterior Cingulate Cortex

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Min Zhao ◽  
Zhaoqin Wang ◽  
Zhijun Weng ◽  
Fang Zhang ◽  
Guona Li ◽  
...  
Keyword(s):  
Anterior Cingulate Cortex ◽  
Intrathecal Injection ◽  
Cingulate Cortex ◽  
Visceral Hypersensitivity ◽  
Anterior Cingulate ◽  
Group Model ◽  
Western Blots ◽  
Medial Thalamus ◽  
Protein Levels ◽  
Model Control

Objective. To explore whether the effect of electroacupuncture (EA) on visceral hypersensitivity (VH) in rats with irritable bowel syndrome (IBS) is related to the changes of astrocyte activation in the medial thalamus (MT) and anterior cingulate cortex (ACC). Method. Male Sprague-Dawley rats were randomly divided into the normal control (NC) group, model control (MC) group, electroacupuncture (EA) group, and fluorocitrate (FCA) group. A model of visceral hypersensitivity was established by neonatal colorectal irritation. In the EA group, needles were inserted into the skin at the Tianshu (ST25) and Shangjuxu (ST37) acupoints, once a day for 7 days. The FCA group received intrathecal injection of FCA on the 1st, 4th, and 7th days. Visceral hypersensitivity was evaluated by the abdominal withdrawal reflex (AWR), and glial fibrillary acidic protein (GFAP) mRNA and protein levels in the MT and ACC were detected by real-time PCR, immunohistochemistry, and western blots. Results. The AWR score in the MC group was significantly higher than in the NC group, and EA and FCA reduced the AWR score of VH rats. GFAP mRNA and protein levels in the MT and ACC of rats in the MC group were significantly increased compared with the NC group. After either electroacupuncture or fluorocitrate, GFAP mRNA and protein levels in the MT and ACC were both clearly reduced. Conclusion. Electroacupuncture alleviates IBS visceral hypersensitivity by inhibiting the activation of astrocytes in the MT and ACC.

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