Temporal and anatomical variations of brain water apparent diffusion coefficient in perinatal cerebral hypoxic-ischemic injury: Relationships to cerebral energy metabolism

1998 ◽  
Vol 39 (6) ◽  
pp. 920-927 ◽  
Author(s):  
John S. Thornton ◽  
Roger J. Ordidge ◽  
Juliet Penrice ◽  
Ernest B. Cady ◽  
Philip N. Amess ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Energy Metabolism ◽  
Apparent Diffusion Coefficient ◽  
Ischemic Injury ◽  
Anatomical Variations ◽  
Cerebral Energy Metabolism ◽  
Apparent Diffusion ◽  
Brain Water ◽  
Hypoxic Ischemic Injury

scholarly journals Erythropoietin Protects from Post-Traumatic Edema in the Rat Brain

2007 ◽  
Vol 27 (7) ◽  
pp. 1369-1376 ◽  
Author(s):  
Olivier Verdonck ◽  
Hana Lahrech ◽  
Gilles Francony ◽  
Olivier Carle ◽  
Régine Farion ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Brain Edema ◽  
Acceleration Model ◽  
Apparent Diffusion ◽  
Post Traumatic ◽  
Biochemical Mechanisms ◽  
Impact Acceleration ◽  
Magnetic Resonance Imaging Mri ◽  
Brain Water

Erythropoietin (Epo) is gaining interest in various neurological insults as a possible neuroprotective agent. We determined the effects of recombinant human Epo (rhEpo, 5000 IU per kg bw) on brain edema induced in rats by traumatic brain injury (TBI; impact-acceleration model; rhEpo administration 30 mins after injury). Magnetic resonance imaging (MRI) and a gravimetric technique were applied. In the MRI experiments, the apparent diffusion coefficient (ADC) and the tissue T1 relaxation time were measured hourly in the neocortex and caudoputamen, during a 6 h time span after TBI. In the gravimetric experiments, brain water content (BWC) was determined in these two regions, 6 h after TBI. Apparent diffusion coefficient measurements showed that rhEpo decreased brain edema early and durably. Gravimetric measurements showed that rhEpo decreased BWC at H6 in the neocortex as well as in the caudoputamen. No significant differences in ADC, in T1, or in BWC were found between rhEpo treated-TBI rats and sham-operated rats. Our findings show that post-traumatic administration of rhEpo can significantly reduce the development of brain edema in a model of diffuse TBI. Further studies should be conducted to identify the biochemical mechanisms involved in these immediate effects and to assess the use of rhEpo as a possible therapy for post-traumatic brain edema.

Reversible, reproducible reduction of brain water apparent diffusion coefficient by cortical electroshocks

1997 ◽  
Vol 37 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Jianhui Zhong ◽  
Ognen A. C. Petroff ◽  
Lisa A. Pleban ◽  
John C. Gore ◽  
James W. Prichard
Keyword(s):  
Diffusion Coefficient ◽  
Apparent Diffusion Coefficient ◽  
Apparent Diffusion ◽  
Brain Water

scholarly journals Secondary Deterioration of Apparent Diffusion Coefficient After 1-Hour Transient Focal Cerebral Ischemia in Rats

2000 ◽  
Vol 20 (10) ◽  
pp. 1474-1482 ◽  
Author(s):  
Laszlo Olah ◽  
Stefan Wecker ◽  
Mathias Hoehn
Keyword(s):  
Diffusion Coefficient ◽  
Energy Metabolism ◽  
Cerebral Ischemia ◽  
Apparent Diffusion Coefficient ◽  
Focal Cerebral Ischemia ◽  
Lesion Volume ◽  
Ischemic Lesion ◽  
Early Reperfusion ◽  
Transient Focal Cerebral Ischemia ◽  
Apparent Diffusion

Recent investigations on transient focal cerebral ischemia suggested recovery of energy metabolism during early reperfusion, but followed by secondary energy failure. As disturbances of energy metabolism are reflected by changes of the apparent diffusion coefficient (ADC) of water, the aim of the current study was to follow the dynamics of the ADC during 1 hour of middle cerebral artery occlusion (MCAO) and 10 hours of reperfusion. The right MCA was occluded in male Wistar rats inside the magnet using a remotely controlled thread occlusion model. Diffusion-, perfusion-, and T2-weighted images were performed repetitively, and ADC, perfusion, and T2maps were calculated and normalized to the respective preischemic value. The lesion volume at each time point was defined by ADC < 80% of control. At the end of 1-hour MCAO the hemispheric lesion volume was 22.3 ± 9.0%; it decreased to 6.4 ± 5.7% in the first 2 hours of reperfusion ( P < 0.01), but then increased again, and by the end of 10 hours of reperfusion reached 17.3 ± 9.3%. The mean relative ADC in the end ischemic lesion volume significantly improved within 2 hours of reperfusion (from 65.7 ± 1.2% to 90.1 ± 6.7% of control), but later declined and decreased to 75.4 ± 7.3% of control by the end of the experiment. Pixels with secondary deterioration of ADC showed a continuous increase of T2value during the first 2 hours of reperfusion in spite of ADC improvement, indicating improving cytotoxic, but generation of vasogenic edema during early reperfusion. A significant decrease of the perfusion level was not observed during 10 hours of recirculation. The authors conclude that the improvement of ADC in the early phase of reperfusion may be followed by secondary deterioration that was not caused by delayed hypoperfusion.

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