Correlation of spectroscopy and magnetization transfer imaging in the evaluation of demyelinating lesions and normal appearing white matter in multiple sclerosis

1994 ◽  
Vol 32 (3) ◽  
pp. 285-293 ◽  
Author(s):  
John F. Hiehle ◽  
Robert E. Lenkinski ◽  
Robert I. Grossman ◽  
Vincent Dousset ◽  
Karen N. Ramer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Magnetization Transfer Imaging ◽  
Normal Appearing White Matter ◽  
Demyelinating Lesions

A Magnetization Transfer Imaging Study of Normal-Appearing White Matter in Multiple Sclerosis

Neurology ◽  
1995 ◽  
Vol 45 (3) ◽  
pp. 478-482 ◽  
Author(s):  
M. Filippi ◽  
A. Campi ◽  
V. Dousset ◽  
C. Baratti ◽  
V. Martinelli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Imaging Study ◽  
Magnetization Transfer Imaging ◽  
Normal Appearing White Matter

Overexpression of sphingosine-1-phosphate receptors on reactive astrocytes drives neuropathology of multiple sclerosis rebound after fingolimod discontinuation

2018 ◽  
Vol 24 (8) ◽  
pp. 1133-1137 ◽  
Author(s):  
Maria Teresa Giordana ◽  
Paola Cavalla ◽  
Antonio Uccelli ◽  
Alice Laroni ◽  
Fabio Bandini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Disease Activity ◽  
Multiple Sclerosis Patient ◽  
Fatal Outcome ◽  
Reactive Astrocytes ◽  
Normal Appearing White Matter ◽  
Sphingosine 1 Phosphate ◽  
Demyelinating Lesions

We present the neuropathological description of an autoptic case of fatal rebound of disease activity after fingolimod discontinuation in a multiple sclerosis patient. MRI prior to the fatal outcome showed several large tumefactive demyelinating lesions. These lesions were characterized by prominent astrocytic gliosis, with a remarkable preponderance of large hypertrophic reactive astrocytes showing intense expression of sphingosine-1-phosphate receptor 1. Prominent astrocytic gliosis was also diffusely observed in the normal-appearing white matter. Dysregulated sphingosine-1-phosphate signaling on astrocytes following fingolimod withdrawal might represent a possible contributing mechanism to disease rebound and might account for the unusual radiological and neuropathological features observed in the present case.

scholarly journals Hypoperfusion of the Cerebral White Matter in Multiple Sclerosis: Possible Mechanisms and Pathophysiological Significance

2008 ◽  
Vol 28 (10) ◽  
pp. 1645-1651 ◽  
Author(s):  
Jacques De Keyser ◽  
Christel Steen ◽  
Jop P Mostert ◽  
Marcus W Koch
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Adrenergic Receptors ◽  
Perfusion Magnetic Resonance Imaging ◽  
Cerebral White Matter ◽  
Perivascular Spaces ◽  
Axonal Loss ◽  
Normal Appearing White Matter ◽  
Demyelinating Lesions ◽  
The Central Nervous System

Multiple sclerosis (MS) is a disease of the central nervous system characterized by patchy areas of demyelination, inflammation, axonal loss and gliosis, and a diffuse axonal degeneration throughout the so-called normal-appearing white matter (NAWM). A number of recent studies using perfusion magnetic resonance imaging in both relapsing and progressive forms of MS have shown a decreased perfusion of the NAWM, which does not appear to be secondary to axonal loss. The reduced perfusion of the NAWM in MS might be caused by a widespread astrocyte dysfunction, possibly related to a deficiency in astrocytic β2-adrenergic receptors and a reduced formation of cAMP, resulting in a reduced uptake of K+ at the nodes of Ranvier and a reduced release of K+ in the perivascular spaces. Pathologic and imaging studies suggest that ischemic changes might be involved in the development of a subtype of focal demyelinating lesions (type III lesions), and there appears to exist a relationship between decreased white matter perfusion and cognitive dysfunction in patients with MS.

scholarly journals Magnetization transfer and adiabatic T1ρ MRI reveal abnormalities in normal-appearing white matter of subjects with multiple sclerosis

2013 ◽  
Vol 20 (8) ◽  
pp. 1066-1073 ◽  
Author(s):  
Silvia Mangia ◽  
Adam F Carpenter ◽  
Andy E Tyan ◽  
Lynn E Eberly ◽  
Michael Garwood ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Magnetic Resonance Images ◽  
Relaxation Methods ◽  
Normal Appearing White Matter ◽  
Relaxation Parameters ◽  
Relapsing Remitting ◽  
Cortical Gray Matter ◽  
The Brain

Background: Diffuse abnormalities are known to occur within the brain tissue of multiple sclerosis (MS) patients that is “normal appearing” on T1-weighted and T2-weighted magnetic resonance images. Objectives: With the goal of exploring the sensitivity of novel MRI parameters to detect such abnormalities, we implemented an inversion-prepared magnetization transfer (MT) protocol and adiabatic T1ρ and T2ρ rotating frame relaxation methods. Methods: Nine relapsing–remitting MS patients and seven healthy controls were recruited. Relaxation parameters were measured in a single slice just above the lateral ventricles and approximately parallel to the AC-PC line. Results: The MT ratio of regions encompassing the normal-appearing white matter (NAWM) was different in MS patients as compared with controls ( p = 0.043); however, the T1 measured during off-resonance irradiation (T1sat) was substantially more sensitive than the MT ratio for detecting differences between groups ( p = 0.0006). Adiabatic T1ρ was significantly prolonged in the NAWM of MS patents as compared to controls (by 6%, p = 0.026), while no differences were found among groups for T2ρ. No differences among groups were observed in the cortical gray matter for any relaxation parameter. Conclusions: The results suggest degenerative processes occurring in the NAWM of MS, likely not accompanied by significant abnormalities in iron content.

scholarly journals Magnetization transfer ratio measures in normal-appearing white matter show periventricular gradient abnormalities in multiple sclerosis

Brain ◽  
2015 ◽  
Vol 138 (5) ◽  
pp. 1239-1246 ◽  
Author(s):  
Zheng Liu ◽  
Matteo Pardini ◽  
Özgür Yaldizli ◽  
Varun Sethi ◽  
Nils Muhlert ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Magnetization Transfer Ratio ◽  
Transfer Ratio ◽  
Normal Appearing White Matter

Multiple Sclerosis: Magnetization Transfer Histogram Analysis of Segmented Normal-appearing White Matter

Radiology ◽  
2000 ◽  
Vol 216 (2) ◽  
pp. 351-355 ◽  
Author(s):  
Isabelle Catalaa ◽  
Robert I. Grossman ◽  
Dennis L. Kolson ◽  
Jayaram K. Udupa ◽  
Laszlo G. Nyul ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Magnetization Transfer ◽  
Histogram Analysis ◽  
Normal Appearing White Matter
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