scholarly journals Simulations of thermal tissue coagulation and their value for the planning and monitoring of laser-induced interstitial thermotherapy (LITT)

2003 ◽  
Vol 49 (2) ◽  
pp. 351-362 ◽  
Author(s):  
Silvia Puccini ◽  
Nils-Karsten Bär ◽  
Martin Bublat ◽  
Thomas Kahn ◽  
Harald Busse
Keyword(s):  
Interstitial Thermotherapy

scholarly journals Laser interstitial thermotherapy (LITT) for the treatment of tumors of the brain and spine: a brief review

2021 ◽  
Vol 151 (3) ◽  
pp. 429-442
Author(s):  
Clark Chen ◽  
Ian Lee ◽  
Claudio Tatsui ◽  
Theresa Elder ◽  
Andrew E. Sloan
Keyword(s):  
Brain Tumors ◽  
Minimally Invasive ◽  
Radiation Necrosis ◽  
Spinal Metastasis ◽  
Clinical Approach ◽  
Invasive Treatment ◽  
Primary Indication ◽  
Interstitial Thermotherapy ◽  
The Brain

Abstract Introduction Laser Interstitial Thermotherapy (LITT; also known as Stereotactic Laser Ablation or SLA), is a minimally invasive treatment modality that has recently gained prominence in the treatment of malignant primary and metastatic brain tumors and radiation necrosis and studies for treatment of spinal metastasis has recently been reported. Methods Here we provide a brief literature review of the various contemporary uses for LITT and their reported outcomes. Results Historically, the primary indication for LITT has been for the treatment of recurrent glioblastoma (GBM). However, indications have continued to expand and now include gliomas of different grades, brain metastasis (BM), radiation necrosis (RN), other types of brain tumors as well as spine metastasis. LITT is emerging as a safe, reliable, minimally invasive clinical approach, particularly for deep seated, focal malignant brain tumors and radiation necrosis. The role of LITT for treatment of other types of tumors of the brain and for spine tumors appears to be evolving at a small number of centers. While the technology appears to be safe and increasingly utilized, there have been few prospective clinical trials and most published studies combine different pathologies in the same report. Conclusion Well-designed prospective trials will be required to firmly establish the role of LITT in the treatment of lesions of the brain and spine.

Laser interstitial thermotherapy (LITT) monitoring using high-resolution digital mammography: theory and experimental studies

2002 ◽  
Vol 47 (16) ◽  
pp. 2987-2999 ◽  
Author(s):  
Ahmed M Minhaj ◽  
Fabrice Manns ◽  
Peter J Milne ◽  
David B Denham ◽  
Nelson Salas Jr ◽  
...  
Keyword(s):  
High Resolution ◽  
Digital Mammography ◽  
Experimental Studies ◽  
Interstitial Thermotherapy

Laser interstitial thermotherapy in stereotactical neurosurgery

1992 ◽  
Vol 7 (1-4) ◽  
pp. 121-126 ◽  
Author(s):  
F. X. Roux ◽  
L. Merienne ◽  
B. Leriche ◽  
S. Lucerna ◽  
B. Turak ◽  
...  
Keyword(s):  
Interstitial Thermotherapy

scholarly journals Utilization of laser interstitial thermotherapy guided by real-time thermal MRI as an alternative to separation surgery in the management of spinal metastasis

2015 ◽  
Vol 23 (4) ◽  
pp. 400-411 ◽  
Author(s):  
Claudio E. Tatsui ◽  
R. Jason Stafford ◽  
Jing Li ◽  
Jonathan N. Sellin ◽  
Behrang Amini ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Spinal Cord ◽  
Real Time ◽  
Spinal Cord Compression ◽  
Spinal Metastasis ◽  
Cord Compression ◽  
The Mean ◽  
Interstitial Thermotherapy

OBJECT High-grade malignant spinal cord compression is commonly managed with a combination of surgery aimed at removing the epidural tumor, followed by spinal stereotactic radiosurgery (SSRS) aimed at local tumor control. The authors here introduce the use of spinal laser interstitial thermotherapy (SLITT) as an alternative to surgery prior to SSRS. METHODS Patients with a high degree of epidural malignant compression due to radioresistant tumors were selected for study. Visual analog scale (VAS) scores for pain and quality of life were obtained before and within 30 and 60 days after treatment. A laser probe was percutaneously placed in the epidural space. Real-time thermal MRI was used to monitor tissue damage in the region of interest. All patients received postoperative SSRS. The maximum thickness of the epidural tumor was measured, and the degree of epidural spinal cord compression (ESCC) was scored in pre- and postprocedure MRI. RESULTS In the 11 patients eligible for study, the mean VAS score for pain decreased from 6.18 in the preoperative period to 4.27 within 30 days and 2.8 within 60 days after the procedure. A similar VAS interrogating the percentage of quality of life demonstrated improvement from 60% preoperatively to 70% within both 30 and 60 days after treatment. Imaging follow-up 2 months after the procedure demonstrated a significant reduction in the mean thickness of the epidural tumor from 8.82 mm (95% CI 7.38–10.25) before treatment to 6.36 mm (95% CI 4.65–8.07) after SLITT and SSRS (p = 0.0001). The median preoperative ESCC Grade 2 was scored as 4, which was significantly higher than the score of 2 for Grade 1b (p = 0.04) on imaging follow-up 2 months after the procedure. CONCLUTIONS The authors present the first report on an innovative minimally invasive alternative to surgery in the management of spinal metastasis. In their early experience, SLITT has provided local control with low morbidity and improvement in both pain and the quality of life of patients.

In vivo laser-induced interstitial thermotherapy of pig liver with a temperature-controlled diode laser and MRI correlation

2001 ◽  
Vol 29 (4) ◽  
pp. 374-378 ◽  
Author(s):  
Walter A. Wohlgemuth ◽  
G�nther Wamser ◽  
Thomas Reiss ◽  
Theodor Wagner ◽  
Klaus Bohndorf
Keyword(s):  
Diode Laser ◽  
Pig Liver ◽  
Temperature Controlled ◽  
Interstitial Thermotherapy

LITT (Laser Induced Interstitial Thermotherapy) of Benign and Malignant Gliomas in the OPEN MR (0.5 Tesla, GE Signa SP)

2002 ◽  
Vol 17 (2) ◽  
pp. 170-178 ◽  
Author(s):  
Wernholt von Tempelhoff ◽  
Selim Toktamis ◽  
Hans-Joachim Schwarzmeier ◽  
Frank Eickmeyer ◽  
Hendrik Niehoff ◽  
...  
Keyword(s):  
Malignant Gliomas ◽  
Interstitial Thermotherapy

Thermal analysis of laser interstitial thermotherapy inex vivofibro-fatty tissue using exponential functions

2004 ◽  
Vol 49 (9) ◽  
pp. 1609-1624 ◽  
Author(s):  
Nelson Salas ◽  
Fabrice Manns ◽  
Peter J Milne ◽  
David B Denham ◽  
Ahmed M Minhaj ◽  
...  
Keyword(s):  
Thermal Analysis ◽  
Fatty Tissue ◽  
Exponential Functions ◽  
Interstitial Thermotherapy

Predictions of tissue denaturation during experimental laser interstitial thermotherapy for breast tumors

2003 ◽  
Author(s):  
Nelson Salas, Jr. ◽  
Fabrice Manns ◽  
Jean-Marie A. Parel ◽  
Peter J. Milne ◽  
David B. Denham ◽  
...  
Keyword(s):  
Breast Tumors ◽  
Interstitial Thermotherapy
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