Position-independent and tissue-specific expression of porcine whey acidic protein gene from a bacterial artificial chromosome in transgenic mice

2002 ◽  
Vol 63 (2) ◽  
pp. 161-167 ◽  
Author(s):  
Sylvie Rival-Gervier ◽  
C�line Viglietta ◽  
Caroline Maeder ◽  
Joe Attal ◽  
Louis-Marie Houdebine
Keyword(s):  
Bacterial Artificial Chromosome ◽  
Transgenic Mice ◽  
Protein Gene ◽  
Artificial Chromosome ◽  
Whey Acidic Protein ◽  
Acidic Protein ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

Differential expression of the closely linked KISS1, REN, and FLJ10761 genes in transgenic mice

2004 ◽  
Vol 17 (1) ◽  
pp. 4-10 ◽  
Author(s):  
Ravi Nistala ◽  
Xiaoji Zhang ◽  
Curt D. Sigmund
Keyword(s):  
Transgenic Mice ◽  
Human Chromosome ◽  
Expression Profiles ◽  
Expression Patterns ◽  
Artificial Chromosome ◽  
Chromosome 1 ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Human Chromosome 1

We previously reported the development and characterization of transgenic mice containing a large 160-kb P1 artificial chromosome (PAC) encompassing the renin (REN) locus from human chromosome 1. Here we demonstrate that PAC160 not only encodes REN, but also complete copies of the next upstream (KISS1) and downstream ( FLJ10761 ) gene along human chromosome 1. Incomplete copies of the second upstream (PEPP3) and downstream (SOX13) genes are also present. The gene order PEPP3-KISS1-REN-FLJ10761-SOX13 is conserved in mice containing either one or two copies of the REN locus. Despite the close localization of KISS1, REN, and FLJ10761 , they each exhibit distinct, yet overlapping tissue-specific expression profiles in humans. The tissue-specific expression patterns of REN and FLJ10761 were retained in transgenic mice containing PAC160. Expression of REN and FLJ10761 were also proportional to copy number. Expression of KISS1 in PAC160 mice showed both similarities and differences to humans. These data suggest that expression of gene blocks encoded on large genomic clones are retained when the clones are used to generate transgenic mice. Genomic elements which act to insulate genes from their neighbors are also apparently retained.

scholarly journals Tissue-specific expression in the salivary glands of transgenic mice

1992 ◽  
Vol 20 (9) ◽  
pp. 2249-2255 ◽  
Author(s):  
Thomas R. Mikkelsen ◽  
Jakob Brandt ◽  
H.Jakob Larsen ◽  
Birte B. Larsen ◽  
Knud Poulsen ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Salivary Glands ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice

Cell ◽  
1984 ◽  
Vol 38 (3) ◽  
pp. 639-646 ◽  
Author(s):  
Galvin H. Swift ◽  
Robert E. Hammer ◽  
Raymond J. MacDonald ◽  
Ralph L. Brinster
Keyword(s):  
Transgenic Mice ◽  
Specific Expression ◽  
Tissue Specific ◽  
Pancreatic Elastase ◽  
Tissue Specific Expression ◽  
I Gene

Identification and tissue-specific expression of amphioxus GM2 activator protein gene from amphioxusBranchiostoma belcheri

DNA Sequence ◽  
2006 ◽  
Vol 17 (2) ◽  
pp. 122-128
Author(s):  
Nai-Guo Liu ◽  
Nai-Guo Liu ◽  
Shi-Cui Zhang ◽  
Zhen-Hui Liu ◽  
Nai-Guo Liu ◽  
...  
Keyword(s):  
Protein Gene ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Activator Protein ◽  
Gm2 Activator ◽  
Gm2 Activator Protein

scholarly journals Tissue-specific expression of a FMR1/β-galactosidase fusion gene in transgenic mice

1995 ◽  
Vol 4 (3) ◽  
pp. 359-366 ◽  
Author(s):  
Martin Hergersberg ◽  
Koichi Matsuo ◽  
Max Gassmann ◽  
Walter Schaffner ◽  
Bernhard Lüscher ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Fusion Gene ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression

scholarly journals Efficient tissue-specific expression of bovine alpha-lactalbumin in transgenic mice

1989 ◽  
Vol 186 (1-2) ◽  
pp. 43-48 ◽  
Author(s):  
Jean-Luc VILOTTE ◽  
Solange SOULIER ◽  
Marie-George STINNAKRE ◽  
Micheline MASSOUD ◽  
Jean-Claude MERCIER
Keyword(s):  
Transgenic Mice ◽  
Specific Expression ◽  
Tissue Specific ◽  
Tissue Specific Expression ◽  
Alpha Lactalbumin
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