High maternal folic acid intake around conception alters mouse blastocyst lineage allocation and expression of key developmental regulatory genes

2021 ◽  
Author(s):  
R. S. Penailillo ◽  
J. J. Eckert ◽  
M. A. Burton ◽  
G. C. Burdge ◽  
T. P. Fleming ◽  
...  
Keyword(s):  
Folic Acid ◽  
Regulatory Genes ◽  
Mouse Blastocyst ◽  
Folic Acid Intake ◽  
Acid Intake

scholarly journals Folic acid food fortification prevents inadequate folate intake among preschoolers from Ontario

2009 ◽  
Vol 12 (9) ◽  
pp. 1548-1555 ◽  
Author(s):  
Kathleen Hennessy-Priest ◽  
Jill Mustard ◽  
Heather Keller ◽  
Lee Rysdale ◽  
Joanne Beyers ◽  
...  
Keyword(s):  
Folic Acid ◽  
Public Health Intervention ◽  
Folate Intake ◽  
Food Fortification ◽  
Folic Acid Intake ◽  
Cross Sectional ◽  
Dietary Folate ◽  
Supplement Use ◽  
Acid Intake ◽  
Fortified Food

AbstractObjectiveFolic acid food fortification has successfully reduced neural tube defect-affected pregnancies across Canada. The effect of this uncontrolled public health intervention on folate intake among Canadian children is, however, unknown. Our objectives were to determine folic acid intake from food fortification and whether fortification promoted adequate folate intakes, and to describe folic acid-fortified food usage among Ontario preschoolers.DesignCross-sectional data were used from the NutriSTEP™ validation project with preschoolers recruited using convenience sampling. Mean daily total folate and folic acid intakes were estimated from 3 d food records, which included multivitamin supplement use. Comparisons were made to Dietary Reference Intakes, accounting for and excluding fortificant folic acid, to determine the prevalence of inadequate and excessive intakes.SettingCanada.SubjectsTwo hundred and fifty-four preschoolers (aged 3–5 years).ResultsAll participants (130 girls, 124 boys) ate folic acid-fortified foods and 30 % (n76) used folic acid-containing supplements. Mean (se) fortificant folic acid intake was 83 (2) μg/d, which contributed 30 % and 50 % to total folate intake for supplement users and non-users, respectively. The prevalence of total folate intakes below the Estimated Average Requirement was <1 %; however, excluding fortificant folic acid, the prevalence was 32 %, 54 % and 47 % for 3-, 4- and 5-year-olds, respectively. The overall prevalence of folic acid (fortificant and supplemental) intakes above the Tolerable Upper Intake Level was 2 % (7 % among supplement users).ConclusionsFolic acid food fortification promotes dietary folate adequacy and did not appear to result in excessive folic acid intake unless folic acid-containing supplements were consumed.

Periconceptional nonsteroidal anti‐inflammatory drug use, folic acid intake, and the risk of spina bifida

2021 ◽  
Author(s):  
Daina B. Esposito ◽  
Samantha E. Parker ◽  
Allen A. Mitchell ◽  
Sarah C. Tinker ◽  
Martha M. Werler
Keyword(s):  
Folic Acid ◽  
Drug Use ◽  
Spina Bifida ◽  
Folic Acid Intake ◽  
Inflammatory Drug ◽  
Acid Intake ◽  
Anti Inflammatory

scholarly journals The Dihydrofolate Reductase 19 bp Polymorphism Is Not Associated with Biomarkers of Folate Status in Healthy Young Adults, Irrespective of Folic Acid Intake

2015 ◽  
Vol 145 (10) ◽  
pp. 2207-2211 ◽  
Author(s):  
Mari Ozaki ◽  
Anne M Molloy ◽  
James L Mills ◽  
Ruzong Fan ◽  
Yifan Wang ◽  
...  
Keyword(s):  
Young Adults ◽  
Folic Acid ◽  
Dihydrofolate Reductase ◽  
Folic Acid Intake ◽  
Folate Status ◽  
Acid Intake

scholarly journals Factors associated with not using folic acid supplements preconceptionally

2013 ◽  
Vol 17 (10) ◽  
pp. 2344-2350 ◽  
Author(s):  
Judith Manniën ◽  
Ank de Jonge ◽  
Martina C Cornel ◽  
Evelien Spelten ◽  
Eileen K Hutton
Keyword(s):  
Folic Acid ◽  
The Netherlands ◽  
Pregnant Women ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Lifestyle Factors ◽  
Folic Acid Intake ◽  
Factors Associated ◽  
Acid Intake ◽  
Folic Acid Supplements

AbstractObjectiveNeural tube defects are among the most common birth defects worldwide. Folic acid intake from one month before to three months after conception reduces the likelihood of neural tube defects by at least 50 %. Since 1995, several campaigns have been organised in the Netherlands which resulted in 51 % of pregnant women using folic acid supplements during the entire recommended period in the northern part of the Netherlands in 2005. Our research question was to gain insight into the current prevalence and factors associated with inadequate pregnancy-related use of folic acid supplements.DesignData from the DELIVER study were used, which is a population-based cohort study.SettingTwenty midwifery practices across the Netherlands in 2009 and 2010.SubjectsIn total 5975 pregnant women completed a questionnaire covering items on sociodemographic and lifestyle factors, including folic acid intake.ResultsOf our study population, 55·5 % (3318/5975) used folic acid supplements before conception. Several sociodemographic and lifestyle factors were associated with no preconception use of folic acid, of which non-Western ethnicity and not having a partner had the largest effect size.ConclusionsIn the Netherlands, the folic acid intake before conception is suboptimal and has not improved over recent years. Fortification of staple foods with folic acid should be reconsidered as it would provide a more effective means of ensuring an adequate intake, especially for those groups of women who are unlikely to plan their pregnancies or to receive or respond to health promotion messages.

scholarly journals Is High Folic Acid Intake a Risk Factor for Autism?—A Review

2017 ◽  
Vol 7 (12) ◽  
pp. 149 ◽  
Author(s):  
Darrell Wiens ◽  
M. DeSoto
Keyword(s):  
Risk Factor ◽  
Folic Acid ◽  
Folic Acid Intake ◽  
Acid Intake

scholarly journals The adverse effects of an excessive folic acid intake

2016 ◽  
Vol 71 (2) ◽  
pp. 159-163 ◽  
Author(s):  
K R Patel ◽  
A Sobczyńska-Malefora
Keyword(s):  
Folic Acid ◽  
Adverse Effects ◽  
Folic Acid Intake ◽  
Acid Intake

scholarly journals Assessment of the potential effect of incremental increases in folic acid intake on neural tube defects in Australia and New Zealand

2006 ◽  
Vol 30 (4) ◽  
pp. 369-374 ◽  
Author(s):  
Carol Bower ◽  
Nicholas de Klerk ◽  
Siobhan Hickling ◽  
Gina Ambrosini ◽  
Leon Flicker ◽  
...  
Keyword(s):  
Folic Acid ◽  
New Zealand ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Potential Effect ◽  
Folic Acid Intake ◽  
Acid Intake
Sign in / Sign up

Export Citation Format

Share Document