scholarly journals Of Mitochondrial Eve and Steve

2016 ◽  
Vol 83 (1) ◽  
pp. 5-5
Author(s):  
Wonhee Song ◽  
Peter Sutovsky
Keyword(s):  
Mitochondrial Eve

Mitochondrial Eve: wounded, but not dead yet

Science ◽  
1992 ◽  
Vol 257 (5072) ◽  
pp. 873-875 ◽  
Author(s):  
A Gibbons
Keyword(s):  
Mitochondrial Eve

The unmasking of mitochondrial Eve

Science ◽  
1987 ◽  
Vol 238 (4823) ◽  
pp. 24-26 ◽  
Author(s):  
R Lewin
Keyword(s):  
Mitochondrial Eve

scholarly journals May “Mitochondrial Eve” and Mitochondrial Haplogroups Play a Role in Neurodegeneration and Alzheimer's Disease?

2011 ◽  
Vol 2011 ◽  
pp. 1-11 ◽  
Author(s):  
Elena Caldarazzo Ienco ◽  
Costanza Simoncini ◽  
Daniele Orsucci ◽  
Loredana Petrucci ◽  
Massimiliano Filosto ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Critical Role ◽  
Protective Role ◽  
Oxygen Species ◽  
Mitochondrial Haplogroups ◽  
Normal Ageing ◽  
Apoptotic Pathways ◽  
Mitochondrial Eve

Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Multiple evidences suggest that mitochondria may be crucial in ageing-related neurodegenerative diseases. Moreover, mitochondrial haplogroups have been linked to multiple area of medicine, from normal ageing to diseases, including neurodegeneration. Polymorphisms within the mitochondrial genome might lead to impaired energy generation and to increased amount of reactive oxygen species, having either susceptibility or protective role in several diseases. Here, we highlight the role of the mitochondrial haplogroups in the pathogenetic cascade leading to diseases, with special attention to Alzheimer's disease.

scholarly journals Recent common ancestors of all present-day individuals

1999 ◽  
Vol 31 (04) ◽  
pp. 1002-1026 ◽  
Author(s):  
Joseph T. Chang
Keyword(s):  
Population Size ◽  
High Probability ◽  
Common Ancestor ◽  
Recent Common Ancestor ◽  
Expected Number ◽  
The Past ◽  
Most Recent Common Ancestor ◽  
Trace Back ◽  
Fisher Model ◽  
Mitochondrial Eve

Previous study of the time to a common ancestor of all present-day individuals has focused on models in which each individual has just one parent in the previous generation. For example, ‘mitochondrial Eve’ is the most recent common ancestor (MRCA) when ancestry is defined only through maternal lines. In the standard Wright-Fisher model with population size n, the expected number of generations to the MRCA is about 2n, and the standard deviation of this time is also of order n. Here we study a two-parent analog of the Wright-Fisher model that defines ancestry using both parents. In this model, if the population size n is large, the number of generations, 𝒯 n , back to a MRCA has a distribution that is concentrated around lgn (where lg denotes base-2 logarithm), in the sense that the ratio 𝒯 n (lgn) converges in probability to 1 as n→∞. Also, continuing to trace back further into the past, at about 1.77 lgn generations before the present, all partial ancestry of the current population ends, in the following sense: with high probability for large n, in each generation at least 1.77lgn generations before the present, all individuals who have any descendants among the present-day individuals are actually ancestors of all present-day individuals.

scholarly journals All About Mitochondrial Eve: An Interview with Rebecca Cann

PLoS Genetics ◽  
2010 ◽  
Vol 6 (5) ◽  
pp. e1000959 ◽  
Author(s):  
Jane Gitschier
Keyword(s):  
Mitochondrial Eve
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