Endoplasmic reticulum stress is involved in granulosa cell apoptosis during follicular atresia in goat ovaries

2012 ◽  
Vol 79 (6) ◽  
pp. 423-432 ◽  
Author(s):  
Pengfei Lin ◽  
YanZhou Yang ◽  
Xiao Li ◽  
Fenglei Chen ◽  
ChenChen Cui ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Granulosa Cell ◽  
Cell Apoptosis ◽  
Follicular Atresia

Luman recruiting factor regulates endoplasmic reticulum stress in mouse ovarian granulosa cell apoptosis

2013 ◽  
Vol 79 (4) ◽  
pp. 633-639.e3 ◽  
Author(s):  
Yanzhou Yang ◽  
Pengfei Lin ◽  
Fenglei Chen ◽  
Aihua Wang ◽  
Xiangli Lan ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Granulosa Cell ◽  
Cell Apoptosis ◽  
Ovarian Granulosa Cell

Ufmylation regulates granulosa cell apoptosis via ER stress but not oxidative stress during goat follicular atresia

2021 ◽  
Vol 169 ◽  
pp. 47-55
Author(s):  
Xinyan Zhang ◽  
Tong Yu ◽  
Xinyan Guo ◽  
Ruixue Zhang ◽  
Yanni Jia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Er Stress ◽  
Granulosa Cell ◽  
Cell Apoptosis ◽  
Follicular Atresia

scholarly journals miR-26b Promotes Granulosa Cell Apoptosis by Targeting ATM during Follicular Atresia in Porcine Ovary

PLoS ONE ◽  
2012 ◽  
Vol 7 (6) ◽  
pp. e38640 ◽  
Author(s):  
Fei Lin ◽  
Ran Li ◽  
Zeng xiang Pan ◽  
Bo Zhou ◽  
De bing Yu ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Cell Apoptosis ◽  
Follicular Atresia

Effect of Metformin Intervention on Pancreatic β-Cell Apoptosis

2022 ◽  
Vol 12 (4) ◽  
pp. 873-877
Author(s):  
Dongqian Xie ◽  
Zhicheng Gao ◽  
Mei Liu ◽  
Defeng Wang
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cell Apoptosis ◽  
Dependent Manner ◽  
Cycle Arrest ◽  
High Glucose Condition ◽  
M Phase ◽  
Signaling Activation

Metformin is shown to have hypoglycemic effects. However, the relationship between metformin’s intervention in FFA-induced endoplasmic reticulum stress-mediated insulin resistance (IR) and insulin β-cell apoptosis under high-glucose condition remains unclear. Our study intends to assess their relationship. Human pancreatic β-cells were treated with metformin and cell proliferation and IR were detected by MTT assay along with detection of Wnt/β-catenin signaling by RT-PCR, cell cycle and apoptosis by flow cytometry. Metformin inhibited β cell proliferation which was mediated by FFA-induced endoplasmic reticulum stress in a time-dependent and dose-dependent manner as well as induced cell cycle arrest at G2/M phase. In addition, metformin inhibited β-catenin signaling activation and decreased the expression of c-myc, Dvl-2, survivin, Dvl-3, GSK-3β (p-ser9) and promoted GSK-3 (p-tyr216) and Axin-2 expression. In conclusion, metformin inhibits Wnt/β-catenin signaling and promotes FFA to induce endoplasmic reticulum stress, thereby mediating pancreatic β-cells behaviors.

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