Actions of progesterone on uterine immunosuppression and endometrial gland development in the uterine gland knockout (UGKO) ewe

2005 ◽  
Vol 71 (3) ◽  
pp. 347-357 ◽  
Author(s):  
Maria B. Padua ◽  
Şaban Tekin ◽  
Thomas E. Spencer ◽  
Peter J. Hansen
Keyword(s):  
Endometrial Gland ◽  
Uterine Gland ◽  
Gland Development

scholarly journals Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment

2020 ◽  
Author(s):  
Ryan M. Marquardt ◽  
Tae Hoon Kim ◽  
Jung-Yoon Yoo ◽  
Hanna E. Teasley ◽  
Asgerally T. Fazleabas ◽  
...  
Keyword(s):  
Early Pregnancy ◽  
Adult Mouse ◽  
Endometrial Receptivity ◽  
Pathophysiological Mechanism ◽  
Endometrial Gland ◽  
Uterine Gland ◽  
Endometrial Epithelium ◽  
Gland Function ◽  
Gland Development ◽  
Specific Deletion

AbstractThough endometriosis and infertility are clearly associated, the pathophysiological mechanism remains unclear. Previous work has linked endometrial ARID1A loss to endometriosis-related endometrial non-receptivity. Here, we show in mice that ARID1A binds and regulates transcription of the Foxa2 gene required for endometrial gland function. Uterine specific deletion of Arid1a compromises gland development and diminishes Foxa2 and Lif expression. Deletion of Arid1a with Ltf-iCre in the adult mouse endometrial epithelium preserves gland development while still compromising gland function. Mice lacking endometrial epithelial Arid1a are severely sub-fertile due to defects in implantation, decidualization, and endometrial receptivity from disruption of the LIF-STAT3-EGR1 pathway. FOXA2 is also reduced in the endometrium of women with endometriosis in correlation with diminished ARID1A, and both ARID1A and FOXA2 are reduced in non-human primates induced with endometriosis. Our findings describe a role for ARID1A in the endometrial epithelium supporting early pregnancy establishment through the maintenance of gland function.

scholarly journals Progesterone Inhibits Uterine Gland Development in the Neonatal Mouse Uterus1

2012 ◽  
Vol 86 (5) ◽  
Author(s):  
Justyna Filant ◽  
Huaijun Zhou ◽  
Thomas E. Spencer
Keyword(s):  
Neonatal Mouse ◽  
Uterine Gland ◽  
Gland Development

scholarly journals The influence of postnatal nutrition on reproductive tract and endometrial gland development in dairy calves

2017 ◽  
Vol 100 (4) ◽  
pp. 3243-3256 ◽  
Author(s):  
Meghan L. Wilson ◽  
Sarah R. McCoski ◽  
Adam J. Geiger ◽  
R. Michael Akers ◽  
Sally E. Johnson ◽  
...  
Keyword(s):  
Reproductive Tract ◽  
Dairy Calves ◽  
Endometrial Gland ◽  
Gland Development

Short-Term Progesterone Treatment of Neonatal Mice Prevents Uterine Gland Development.

2009 ◽  
Vol 81 (Suppl_1) ◽  
pp. 100-100
Author(s):  
Paul S. Cooke ◽  
Gail C. Ekman ◽  
Joantine C.J. van Esterik ◽  
Philip J. Dziuk ◽  
Sherrie G. Clark ◽  
...  
Keyword(s):  
Short Term ◽  
Neonatal Mice ◽  
Progesterone Treatment ◽  
Uterine Gland ◽  
Gland Development

scholarly journals Chronic estrus disrupts uterine gland development and homeostasis

2018 ◽  
Author(s):  
C. Allison Stewart ◽  
M. David Stewart ◽  
Ying Wang ◽  
Rui Liang ◽  
Yu Liu ◽  
...  
Keyword(s):  
Hormone Secretion ◽  
Gonadotropin Releasing Hormone ◽  
Corpora Lutea ◽  
Ovarian Hormone ◽  
Hormone Signaling ◽  
Antral Follicles ◽  
Uterine Gland ◽  
Persistent Estrus ◽  
Glandular Structures ◽  
Gland Development

AbstractFemale mice homozygous for an engineered Gnrhr E90K mutation have reduced gonadotropin-releasing hormone signaling, leading to infertility. Their ovaries have numerous antral follicles but no corpora lutea, indicating a block to ovulation. These mutants have high levels of circulating estradiol and low progesterone, indicating a state of persistent estrus. This mouse model provided a unique opportunity to examine the lack of cyclic levels of ovarian hormones on uterine gland biology. Although uterine gland development appeared similar to controls during prepubertal development, it was compromised during adolescence in the mutants. By 20 weeks of age, uterine gland development was comparable to controls, but pathologies, including squamous neoplasia, tubal neoplasia, and cribriform glandular structures, were observed. Induction of ovulations by periodic human chorionic gonadotropin treatment did not rescue post-pubertal uterine gland development. Interestingly, progesterone receptor knockout mice, which lack progesterone signaling, also have defects in post-pubertal uterine gland development. However, progesterone treatment did not rescue post-pubertal uterine gland development. These studies indicate that chronically elevated levels of estradiol with low progesterone and therefore an absence of cyclic ovarian hormone secretion disrupts post-pubertal uterine gland development and homeostasis.

Cdh1 Is Essential for Uterine Gland Development and Adult Uterine Function.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 129-129
Author(s):  
Sarah Reardon ◽  
William Burke ◽  
James A. MacLean ◽  
Francesco J. DeMayo ◽  
John P. Lydon ◽  
...  
Keyword(s):  
Uterine Gland ◽  
Uterine Function ◽  
Gland Development

scholarly journals Foxa2 Is Essential for Mouse Endometrial Gland Development and Fertility1

2010 ◽  
Vol 83 (3) ◽  
pp. 396-403 ◽  
Author(s):  
Jae-Wook Jeong ◽  
Inseok Kwak ◽  
Kevin Y. Lee ◽  
Tae Hoon Kim ◽  
Michael J. Large ◽  
...  
Keyword(s):  
Endometrial Gland ◽  
Gland Development

scholarly journals Quantitative analysis of changes in endometrial gland morphology during the bovine oestrous cycle and their association with progesterone levels

Reproduction ◽  
2007 ◽  
Vol 134 (2) ◽  
pp. 365-371 ◽  
Author(s):  
C K Wang ◽  
R S Robinson ◽  
A P F Flint ◽  
G E Mann
Keyword(s):  
Quantitative Analysis ◽  
Luteal Phase ◽  
Oestrous Cycle ◽  
Progesterone Concentration ◽  
Digital Technique ◽  
Endometrial Gland ◽  
Uterine Gland ◽  
Simultaneous Decrease ◽  
Gland Duct ◽  
Cyclic Changes

This study describes a digital technique for uterine morphometry and its application to endometrial structure during the bovine oestrous cycle. Neither the number nor the size of uterine gland ducts changed during the cycle but a reduction in total endometrial area from days 0 to 8 after oestrus led to an increase in the proportion of the endometrium occupied by gland ducts (gland duct density). This effect on day 8 was maintained to day 16. When endometrial morphology was related to circulating progesterone concentrations on days 5 and 8 of the luteal phase, no relationships were found on day 5, but on day 8, a high progesterone concentration was associated with an increased number of gland ducts. Furthermore, in animals slaughtered on day 8, a high progesterone concentration on day 5 was associated with decreased gland duct size, though a simultaneous decrease in endometrial area led to an increase in gland duct density. The results suggest that contrary to expectation, endometrial glands do not grow and regress during the oestrous cycle, although cyclic changes in endometrial area controlled by progesterone lead to changes in gland duct density.

scholarly journals Erratum: Corrigendum: Beyond the brain-Peripheral kisspeptin signaling is essential for promoting endometrial gland development and function

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Silvia León ◽  
Daniela Fernandois ◽  
Alexandra Sull ◽  
Judith Sull ◽  
Michele Calder ◽  
...  
Keyword(s):  
Endometrial Gland ◽  
And Function ◽  
Gland Development ◽  
The Brain
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