Several signaling pathways are involved in the control of cattle oocyte maturation

2004 ◽  
Vol 69 (4) ◽  
pp. 466-474 ◽  
Author(s):  
C�line Vigneron ◽  
Christine Perreau ◽  
Jo�lle Dupont ◽  
Svetlana Uzbekova ◽  
Claude Prigent ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Oocyte Maturation

scholarly journals The Mitogen-Activated Protein Kinase Signaling Pathway Stimulates Mos mRNA Cytoplasmic Polyadenylation duringXenopus Oocyte Maturation

1999 ◽  
Vol 19 (3) ◽  
pp. 1990-1999 ◽  
Author(s):  
Emily L. Howard ◽  
Amanda Charlesworth ◽  
Joseph Welk ◽  
Angus M. MacNicol
Keyword(s):  
Protein Kinase ◽  
Signaling Pathways ◽  
Oocyte Maturation ◽  
Cyclin B1 ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Protein Accumulation ◽  
Cytoplasmic Polyadenylation ◽  
Mitogen Activated Protein ◽  
Mrna Polyadenylation

ABSTRACT The Mos protein kinase is a key regulator of vertebrate oocyte maturation. Oocyte-specific Mos protein expression is subject to translational control. In the frog Xenopus, the translation of Mos protein requires the progesterone-induced polyadenylation of the maternal Mos mRNA, which is present in the oocyte cytoplasm. Both theXenopus p42 mitogen-activated protein kinase (MAPK) and maturation-promoting factor (MPF) signaling pathways have been proposed to mediate progesterone-stimulated oocyte maturation. In this study, we have determined the relative contributions of the MAPK and MPF signaling pathways to Mos mRNA polyadenylation. We report that progesterone-induced Mos mRNA polyadenylation was attenuated in oocytes expressing the MAPK phosphatase rVH6. Moreover, inhibition of MAPK signaling blocked progesterone-induced Mos protein accumulation. Activation of the MAPK pathway by injection of RNA encoding Mos was sufficient to induce both the polyadenylation of synthetic Mos mRNA substrates and the accumulation of endogenous Mos protein in the absence of MPF signaling. Activation of MPF, by injection of cyclin B1 RNA or purified cyclin B1 protein, also induced both Mos protein accumulation and Mos mRNA polyadenylation. However, this action of MPF required MAPK activity. By contrast, the cytoplasmic polyadenylation of maternal cyclin B1 mRNA was stimulated by MPF in a MAPK-independent manner, thus revealing a differential regulation of maternal mRNA polyadenylation by the MAPK and MPF signaling pathways. We propose that MAPK-stimulated Mos mRNA cytoplasmic polyadenylation is a key component of the positive-feedback loop, which contributes to the all-or-none process of oocyte maturation.

scholarly journals Endoplasmic Reticulum (ER) Stress and Unfolded Protein Response (UPR) in Mammalian Oocyte Maturation and Preimplantation Embryo Development

2019 ◽  
Vol 20 (2) ◽  
pp. 409 ◽  
Author(s):  
Tao Lin ◽  
Jae Lee ◽  
Jung Kang ◽  
Hyeon Shin ◽  
Ju Lee ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Signaling Pathways ◽  
Embryo Development ◽  
Oocyte Maturation ◽  
Preimplantation Embryo ◽  
Preimplantation Embryo Development ◽  
Unfolded Protein ◽  
Protein Response

Mammalian oocytes and early embryos derived from in vitro production are highly susceptible to a variety of cellular stresses. During oocyte maturation and preimplantation embryo development, functional proteins must be folded properly in the endoplasmic reticulum (ER) to maintain oocyte and embryo development. However, some adverse factors negatively impact ER functions and protein synthesis, resulting in the activation of ER stress and unfolded protein response (UPR) signaling pathways. ER stress and UPR signaling have been identified in mammalian oocytes and embryos produced in vitro, suggesting that modulation of ER stress and UPR signaling play very important roles in oocyte maturation and the development of preimplantation embryos. In this review, we briefly describe the current state of knowledge regarding ER stress, UPR signaling pathways, and their roles and mechanisms in mammalian (excluding human) oocyte maturation and preimplantation embryo development.

scholarly journals Effect of Rat Medicated Serum Containing You Gui Wan on Mouse OocyteIn VitroMaturation and Subsequent Fertilization Competence

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Xiao-Hui Jiang ◽  
Yan-li Deng ◽  
Hua Lu ◽  
Heng Duan ◽  
Xia Zhen ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Signaling Pathways ◽  
Oocyte Maturation ◽  
Follicle Stimulating Hormone ◽  
Mouse Oocyte ◽  
Herbal Formula ◽  
Rat Serum ◽  
Normal Rat

You Gui Wan (YGW) is a classic herbal formula in traditional Chinese medicine (TCM) used for the clinical treatment of infertility. This study was to explore whether YGW has an impact on mouse oocyte maturationin vitroand subsequent fertilization competence. Rat medicated serum containing YGW was prepared by orally administrating YGW. Mouse immature oocytes were cultured with YGW medicated serum and compared to those cultured with or without normal rat serum or follicle-stimulating hormone (FSH). YGW medicated serum significantly increased the percentages of matured oocytes when compared to the groups with or without normal rat serum (P< 0.01). Furthermore, YGW medicated serum increased the rate ofin vitrofertilization (IVF) when compared to the groups treated with FSH and with or without normal rat serum (P< 0.001). YGW medicated serum also had significant effects on the mRNA expressions of PKA, CREB, MAPK, PKC, PKG, and MPF and the concentrations of cAMP, cGMP, and NO in matured oocytes. These results indicate that YGW can promote mouse oocyte maturation and IVFin vitro. Signaling pathways, such as the cAMP/PKA/MAPK, the PKC-MAPK, and the NO-cGMP-PKG pathway, which are similar to those induced by FSH, may be responsible for this action.

scholarly journals RASD1 Knockdown Results in Failure of Oocyte Maturation

2016 ◽  
Vol 40 (6) ◽  
pp. 1289-1302 ◽  
Author(s):  
Youngeun Lee ◽  
Kyeoung-Hwa Kim ◽  
Hyemin Yoon ◽  
Ok-Hee Lee ◽  
Eunyoung Kim ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Oocyte Maturation ◽  
Iron Homeostasis ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Germinal Vesicle ◽  
Time Lapse ◽  
Small Gtpases ◽  
Spindle Formation ◽  
Chromosome Alignment

Background: Ras dexamethasone-induced protein (RASD1) is a member of Ras superfamily of small GTPases. RASD1 regulates various signaling pathways involved in iron homeostasis, growth hormone secretion, and circadian rhythm. However, RASD1 function in oocyte remains unknown. Methods: Using immunohistochemistry, immunofluorescence, and quantitative real-time RT-PCR, RASD1 expression in mouse ovary and RASD1 role in oocyte maturation-related gene expression, spindle formation, and chromosome alignment were analyzed. RNAi microinjection and time-lapse video microscopy were used to examine the effect of Rasd1 knockdown on oocyte maturation. Results: RASD1 was highly detected in oocytes transitioning from primordial to secondary follicles. Rasd1 was highly expressed in germinal vesicle (GV), during GV breakdown, and in metaphase I (MI) stage as oocytes mature, and its expression was significantly downregulated in MII stage. With knockdown of Rasd1, maturation in GV oocytes was arrested at MI stage, showing disrupted meiotic spindling and chromosomal misalignment. In addition, Obox4 and Arp2/3, engaged in MI-MII transition and cytokinesis, respectively, were misregulated in GV oocytes by Rasd1 knockdown. Conclusion: These findings suggest that RASD1 is a novel factor in MI-MII oocyte transition and may be involved in regulating the progression of cytokinesis and spindle formation, controlling related signaling pathways during oocyte maturation.

Deregulation of key signaling pathways involved in oocyte maturation in FMR1 premutation carriers with Fragile X-associated primary ovarian insufficiency

Gene ◽  
2015 ◽  
Vol 571 (1) ◽  
pp. 52-57 ◽  
Author(s):  
M.I. Alvarez-Mora ◽  
L. Rodriguez-Revenga ◽  
I. Madrigal ◽  
F. Garcia-Garcia ◽  
M. Duran ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Oocyte Maturation ◽  
Fragile X ◽  
Primary Ovarian Insufficiency ◽  
Ovarian Insufficiency ◽  
Fmr1 Premutation

scholarly journals Cyclooxygenase-2-derived Prostaglandin E2Directs Oocyte Maturation by Differentially Influencing Multiple Signaling Pathways

2006 ◽  
Vol 281 (48) ◽  
pp. 37117-37129 ◽  
Author(s):  
Toshifumi Takahashi ◽  
Jason D. Morrow ◽  
Haibin Wang ◽  
Sudhansu K. Dey
Keyword(s):  
Signaling Pathways ◽  
Oocyte Maturation ◽  
Cyclooxygenase 2 ◽  
Multiple Signaling
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