Muonium atom addition to pyridine and to the pyridinium cation

2001 ◽  
Vol 39 (8) ◽  
pp. 438-442 ◽  
Author(s):  
Christopher J. Rhodes ◽  
Harry Morris ◽  
Ivan D. Reid
Keyword(s):  
Muonium Atom ◽  
Pyridinium Cation

The 1:2 bis(maleonitriledithiolato)palladium(II) complex of theN-(2-fluoro-4-bromobenzyl)pyridinium cation

2003 ◽  
Vol 59 (4) ◽  
pp. m157-m159 ◽  
Author(s):  
Youcun Chen ◽  
Jingli Xie ◽  
Xiaoming Ren ◽  
Guangxiang Liu
Keyword(s):  
Pyridinium Cation

Investigation of logarithmic contributions in the electron-to-muon mass ratio to the shift of the S energy levels in the muonium atom

2003 ◽  
Vol 66 (5) ◽  
pp. 893-901 ◽  
Author(s):  
N. A. Boikova ◽  
S. V. Kleshchevskaya ◽  
Yu. N. Tyukhtyaev ◽  
R. N. Faustov
Keyword(s):  
Energy Levels ◽  
Mass Ratio ◽  
Muonium Atom ◽  
Muon Mass

1H NMR Study of Molecular Motions in Thiourea Pyridinium Halide Inclusion Compounds

2003 ◽  
Vol 58 (11) ◽  
pp. 638-644 ◽  
Author(s):  
M. Grottel ◽  
A. Pajzderska ◽  
J. Wasicki
Keyword(s):  
Inclusion Compounds ◽  
Symmetry Axis ◽  
Activation Parameters ◽  
Lattice Relaxation ◽  
Lattice Relaxation Time ◽  
Spin Lattice Relaxation ◽  
Hindered Rotation ◽  
Pyridinium Cation ◽  
Spin Lattice ◽  
Nmr Study

The proton NMR second moment and spin-lattice relaxation time have been studied for polycrystalline inclusion compounds of thiourea pyridinium chloride, bromide, iodide and their perdeuterated analogues in a wide temperature range. The pyridinium cation reorientation around the pseudohexagonal C6’ symmetry axis over inequivalent barriers and hindered rotation of the thiourea molecule around its C=S bond have been revealed. The activation parameters of the both motions have been found.

scholarly journals Rational design, synthesis, and evaluation of uncharged, “smart” bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase

2020 ◽  
Vol 295 (13) ◽  
pp. 4079-4092 ◽  
Author(s):  
Lukas Gorecki ◽  
Oksana Gerlits ◽  
Xiaotian Kong ◽  
Xiaolin Cheng ◽  
Donald K. Blumenthal ◽  
...  
Keyword(s):  
Active Center ◽  
Rational Design ◽  
Structural Diversity ◽  
Success Rates ◽  
Design Synthesis ◽  
X Ray ◽  
Pyridinium Cation ◽  
Pesticide Exposures ◽  
The Central Nervous System

Organophosphate (OP) intoxications from nerve agent and OP pesticide exposures are managed with pyridinium aldoxime–based therapies whose success rates are currently limited. The pyridinium cation hampers uptake of OPs into the central nervous system (CNS). Furthermore, it frequently binds to aromatic residues of OP-inhibited acetylcholinesterase (AChE) in orientations that are nonproductive for AChE reactivation, and the structural diversity of OPs impedes efficient reactivation. Improvements of OP antidotes need to include much better access of AChE reactivators to the CNS and optimized orientation of the antidotes' nucleophile within the AChE active-center gorge. On the basis of X-ray structures of a CNS-penetrating reactivator, monoxime RS194B, reversibly bound to native and venomous agent X (VX)–inhibited human AChE, here we created seven uncharged acetamido bis-oximes as candidate antidotes. Both oxime groups in these bis-oximes were attached to the same central, saturated heterocyclic core. Diverse protonation of the heterocyclic amines and oxime groups of the bis-oximes resulted in equilibration among up to 16 distinct ionization forms, including uncharged forms capable of diffusing into the CNS and multiple zwitterionic forms optimal for reactivation reactions. Conformationally diverse zwitterions that could act as structural antidote variants significantly improved in vitro reactivation of diverse OP-human AChE conjugates. Oxime group reorientation of one of the bis-oximes, forcing it to point into the active center for reactivation, was confirmed by X-ray structural analysis. Our findings provide detailed structure-activity properties of several CNS-directed, uncharged aliphatic bis-oximes holding promise for use as protonation-dependent, conformationally adaptive, “smart” accelerated antidotes against OP toxicity.

Synthesis and photochemical and magnetic properties of Cr, Mn, Fe, and Co complexes based on the 1-{(1′,3′,3′-trimethylspiro[2H-1-benzopyran-2,2′-indolin]-8-yl)methyl}pyridinium cation

2008 ◽  
Vol 57 (7) ◽  
pp. 1451-1460 ◽  
Author(s):  
N. A. Sanina ◽  
S. M. Aldoshin ◽  
G. V. Shilov ◽  
E. V. Kurganova ◽  
E. A. Yurieva ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Pyridinium Cation

New recoil-effect-induced contributions to the fine shift of S levels in the muonium atom

2001 ◽  
Vol 64 (5) ◽  
pp. 917-920 ◽  
Author(s):  
N. A. Boikova ◽  
Yu. N. Tyukhtyaev ◽  
R. N. Faustov
Keyword(s):  
Recoil Effect ◽  
Muonium Atom
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