Reducing impacts of organism variability in metabolomics via time trajectory in vivo NMR

2018 ◽  
Vol 56 (11) ◽  
pp. 1117-1123 ◽  
Author(s):  
Maryam Tabatabaei Anaraki ◽  
Myrna J. Simpson ◽  
André J. Simpson
Keyword(s):  
In Vivo Nmr

In-vivo NMR studies of deuterium-labeled photosensitizers in mice tumor model

1993 ◽  
Author(s):  
Subbaraya Ramaprasad ◽  
Y. H. Liu ◽  
R. K. Pandey ◽  
Fuu-Yau Shiau ◽  
Kevin M. Smith
Keyword(s):  
Tumor Model ◽  
Nmr Studies ◽  
In Vivo Nmr

Quality assessment in in vivo NMR spectroscopy: VI. Multicentre quantification of MRS test signals

1995 ◽  
Vol 13 (1) ◽  
pp. 169-176 ◽  
Author(s):  
R. de Beer ◽  
P. Bachert-Baumann ◽  
W.M.M.J. Bovee ◽  
E. Cady ◽  
J. Chambron ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Quality Assessment ◽  
In Vivo Nmr ◽  
In Vivo Nmr Spectroscopy

An in Vivo NMR probe circuit for improved sensitivity

1983 ◽  
Vol 54 (3) ◽  
pp. 526-532 ◽  
Author(s):  
Joseph Murphy-Boesch ◽  
Alan P Koretsky
Keyword(s):  
In Vivo Nmr

In Vivo NMR, Applications, 31P*

2010 ◽  
pp. 1112-1117
Author(s):  
Ruth M. Dixon ◽  
Peter Styles
Keyword(s):  
In Vivo Nmr

Ex Vivo MuEtinuciear NMR Spectroscopy of Perfused, Respiring Rat Brain Slices: Model Studies of Hypoxia, Ischemia, and Excitotoxscit

1997 ◽  
Author(s):  
L. Litt ◽  
M.T. Espanol
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Nmr Spectroscopy ◽  
Clinical Care ◽  
Brain Slices ◽  
In Vivo Nmr ◽  
In Vivo Nmr Spectroscopy ◽  
Permanent Brain Damage ◽  
The Brain

We believe there are important roles for in vivo NMR spectroscopy techniques in studies of protection and treatment in stroke. Perhaps the primary utility of in vivo NMR spectroscopy is to establish the relevance of metabolic integrity, intracellular pH, and intracellular energy stores to concurrent changes occurring both at gross physiological levels (e.g., changes in cerebral blood flow, or blood oxygenation), and at microscopic or cellular levels. It has long been known that the brain is exquisitely sensitive to deprivations of oxygen, glucose, and cerebral blood flow. Routine human surgery on a limb takes place every day with tourniquets stopping all blood flow for up to two hours. In contrast, the deprivation of all blood flow to the brain (global ischemia) for approximately 5 minutes can result in severe, permanent brain damage. Research has gone on for more than 30 years to understand why the brain’s revival time is so much shorter, and to discover brain biochemical interventions that might dramatically extend the brain’s intolerance beyond 5 minutes, and therefore be relevant to protection and treatment of stroke. (Kogure and Hossmann, 1985; 1993) Stroke, defined as a permanent neurologic deficit arising from the death of brain cells, kills ∼ 150,000 people in the U.S.A. each year, and is the third leading cause of death (Feinleib et al., 1993). It is the next malady to escape, once one has dodged death from cardiovascular disease and cancer. Many, if not most, U.S.A. stroke victims will receive neurological clinical care not substantially different from what was provided 30 years ago. Most stroke patients will be put in intensive care units where blood pressure will be regulated and kept in a “safe” range, with the body given supportive care and the brain given an opportunity to heal itself. The problem of stroke is actually quite complex because there are several different kinds of stroke (ischemic, hemorrhagic, etc.), and because numerous systemic physiological factors are of relevance. Nevertheless, exciting advances in brain biochemistry suggest that stroke therapy and prophylaxis axe likely to improve dramatically in the near future (Zivin and Choi, 1991).

scholarly journals Ex vivo Comprehensive Multiphase NMR of whole organisms: A complementary tool to in vivo NMR

2020 ◽  
Vol 6 ◽  
pp. 100051 ◽  
Author(s):  
Rajshree Ghosh Biswas ◽  
Blythe Fortier-McGill ◽  
Mohammad Akhter ◽  
Ronald Soong ◽  
Paris Ning ◽  
...  
Keyword(s):  
Ex Vivo ◽  
In Vivo Nmr
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