Recent advances in the structure elucidation of small organic molecules by the LSD software

2013 ◽  
Vol 51 (8) ◽  
pp. 447-453 ◽  
Author(s):  
Bertrand Plainchont ◽  
Vicente de Paulo Emerenciano ◽  
Jean-Marc Nuzillard
Keyword(s):  
Structure Elucidation ◽  
Organic Molecules ◽  
Small Organic Molecules ◽  
Recent Advances

ChemInform Abstract: Recent Advances in Small Organic Molecules as DNA Intercalating Agents: Synthesis, Activity, and Modeling

ChemInform ◽  
2014 ◽  
Vol 45 (19) ◽  
pp. no-no
Author(s):  
Antonio Rescifina ◽  
Chiara Zagni ◽  
Maria Giulia Varrica ◽  
Venerando Pistara ◽  
Antonino Corsaro
Keyword(s):  
Organic Molecules ◽  
Small Organic Molecules ◽  
Recent Advances ◽  
Synthesis Activity ◽  
Intercalating Agents

Recent Advances in the Chemical Synthesis of Marine Acidic Carbohydrates

2020 ◽  
Vol 24 ◽  
Author(s):  
Xinru Li ◽  
Depeng Wang ◽  
Ping Zhang ◽  
Guangli Yu ◽  
Chao Cai
Keyword(s):  
Chemical Synthesis ◽  
Organic Molecules ◽  
Building Blocks ◽  
Biological Functions ◽  
Small Organic Molecules ◽  
Sar Studies ◽  
Structure Activity ◽  
Recent Advances ◽  
Powerful Approach ◽  
Polysaccharide Derivatives

: The ocean supplies abundant active compounds, including small organic molecules, proteins, lipids, and carbohydrates, with diverse biological functions. The high-value transformation of marine carbohydrates primarily refers to their pharmaceutical, food, and cosmetic applications. However, it is still a big challenge to obtain these marine carbohydrates in well-defined structures. Synthesis is a powerful approach to access marine oligosaccharides, polysaccharide derivatives, and glycomimetics. In this review, we focus on the chemical synthesis of marine acidic carbohydrates with acidic ester groups or uronic acid building blocks including alginate, glycosaminoglycans. Regioselective sulfation using a chemical approach is also highlighted in the synthesis of marine oligosaccharides, as well as the multivalent glycodendrimers and glycopolymers for achieving specific functions. This review summarizes recent advances in the synthesis of marine acidic carbohydrates, as well as their preliminary structure activity relationship (SAR) studies, which establishes a foundation for the development of novel marine carbohydrate-based drugs and functional reagents.

scholarly journals New Improvements in Automatic Structure Elucidation Using the LSD (Logic for Structure Determination) and the SISTEMAT Expert Systems

2010 ◽  
Vol 5 (5) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Bertrand Plainchont ◽  
Jean-Marc Nuzillard ◽  
Gilberto V. Rodrigues ◽  
Marcelo J. P. Ferreira ◽  
Marcus T. Scotti ◽  
...  
Keyword(s):  
Natural Products ◽  
Expert Systems ◽  
Structure Determination ◽  
Structure Elucidation ◽  
Organic Molecules ◽  
Computer Assisted ◽  
Small Organic Molecules ◽  
Automatic Structure ◽  
Structure Generator ◽  
Computer Assisted Structure Elucidation

This article describes the integration of the LSD (Logic for Structure Determination) and SISTEMAT expert systems that were both designed for the computer-assisted structure elucidation of small organic molecules. A first step has been achieved towards the linking of the SISTEMAT database with the LSD structure generator. The skeletal descriptions found by the SISTEMAT programs are now easily transferred to LSD as substructural constraints. Examples of the synergy between these expert systems are given for recently reported natural products.

Recent advances in small organic molecules as DNA intercalating agents: Synthesis, activity, and modeling

2014 ◽  
Vol 74 ◽  
pp. 95-115 ◽  
Author(s):  
Antonio Rescifina ◽  
Chiara Zagni ◽  
Maria Giulia Varrica ◽  
Venerando Pistarà ◽  
Antonino Corsaro
Keyword(s):  
Organic Molecules ◽  
Small Organic Molecules ◽  
Recent Advances ◽  
Synthesis Activity ◽  
Intercalating Agents
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